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2,277 Newest Publications about the topic elongation


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Non‐catalytic N‐terminal domain negatively influences the nucleotide exchange activity of translation elongation factor 1Bα

20-Nov-2015 | Tetiana V. Trosiuk, Vyacheslav F. Shalak, Roman H. Szczepanowski, Boris S. Negrutskii, Anna V. El'skaya, FEBS Journal, 2015

Abstract The eukaryotic translation elongation factor 1Bα (eEF1Bα) is a functional homologue of the bacterial factor EF‐Ts and is a component of the macromolecular eEF1B complex. eEF1Bα functions as a catalyst of guanine nucleotide exchange in the translation elongation factor 1A (eEF1A). The ...


Synthesis of Denosomin–Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer’s Disease Activities

20-Nov-2015 | Kenji Sugimoto; Hisanari Yajima; Yusuke Hayashi; Daishiro Minato; Sayuri Terasaki; Chihiro Tohda; Yuji Matsuya, Organic Letters, 2015

As an extension of previously conducted studies on developing an anti-Alzheimer’s disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension ...


Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

19-Nov-2015 | Yitao Duan, Peiyuan Yao, Yuncheng Du, Jinhui Feng, Qiaqing Wu and Dunming Zhu, Beilstein Journal of Organic Chemistry, 2015

Abstract α,β-Unsaturated esters are versatile building blocks for organic synthesis and of significant importance for industrial applications. A great variety of synthetic methods have been developed, and quite a number of them use aldehydes as precursors. Herein we report a chemo-enzymatic ...


Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues

18-Nov-2015 | Brian J. Larsen, Zhankui Sun, Eric Lachacz, Yaroslav Khomutnyk, Matthew B. Soellner, Pavel Nagorny, Chemistry - A European Journal, 2015

Abstract The studies culminating in the total synthesis of the glutarimide‐containing eukaryote translation elongation inhibitor lactimidomycin are described. The optimized synthetic route features a ZnII‐mediated intramolecular Horner–Wadsworth–Emmons (HWE) reaction resulting in a highly ...


Helicobacter pylori CagA protein induces factors involved in the Epithelial‐to–Mesenchymal‐Transition (EMT) in infected gastric epithelial cells in an EPIYA‐ phosphorylation‐dependent manner

13-Nov-2015 | Ioanna S. Sougleri, Konstantinos S. Papadakos, Mairi P. Zadik, Mary Mavri‐Vavagianni, Andreas F. Mentis, Dionyssios ..., FEBS Journal, 2015

Abstract As a result of H. pylori adhesion to gastric epithelial cells the bacterial effector CagA is translocated intracellularly and following its hierarchic tyrosine phosphorylation on multiple EPIYA motifs, deregulates cellular polarity and contributes to the induction of an elongation and ...


Capitate Glandular Trichomes of Paragutzlaffia henryi Harbor New Phytotoxic Labdane Diterpenoids

10-Nov-2015 | Ying Wang; Shi-Hong Luo; Juan Hua; Yan Liu; Shu-Xi Jing; Xiao-Nian Li; Sheng-Hong Li, Journal of Agricultural and Food Chemistry, 2015

The morphology and chemical profile of the capitate glandular trichomes (CGTs) of Paragutzlaffia henryi (Acanthaceae) were investigated. Four new labdane diterpenoids named paraguhenryisins A–D (1–4), together with the known physacoztomatin (5), were localized to the CGTs using laser ...


Investigation on the Synthesis of Shigella flexneri Specific Oligosaccharides Using Disaccharides as Potential Transglucosylase Acceptor Substrates

10-Nov-2015 | Stéphane Salamone; Catherine Guerreiro; Emmanuelle Cambon; Jason M. Hargreaves; Nathalie Tarrat; Magali Remaud-Siméo ..., The Journal of Organic Chemistry, 2015

Chemo-enzymatic strategies hold great potential for the development of stereo- and regioselective syntheses of structurally defined bioactive oligosaccharides. Herein, we illustrate the potential of the appropriate combination of a planned chemo-enzymatic pathway and an engineered biocatalyst for ...


Influence of Pre‐Solution Treatment on Microstructure and Mechanical Properties of Mg–Gd–Nd–Zn–Zr Alloy Processed by ECAP 

09-Nov-2015 | Yong Liu, Zhi Xin Kang, Jun Yi Zhang, Fen Wang, Yuan Yuan Li, Advanced Engineering Materials, 2015

Equal channel angular pressing (ECAP) works as a useful method for microstructure refinement and strength hardening. Billets of the as‐cast and solution‐treated Mg–Gd–Nd–Zn–Zr alloy are processed by ECAP to investigate influence of pre‐solution treatment on the microstructure and mechanical ...


Toughened elastomer/polyhedral oligomeric silsesquioxane (POSS)‐intercalated rectorite nanocomposites: Preparation, microstructure, and mechanical properties

06-Nov-2015 | Yulai Zhao, Xiancai Jiang, Xiangzhou Zhang, Linxi Hou, Polymer Composites, 2015

Improving the properties and behaviors of polymeric materials is significantly important both in industry and academic area. In this contribution, natural rubber (NR) and ethylene‐vinyl acetate copolymer (EVA) based nanocomposites were prepared using polyhedral oligomeric silsesquioxane (POSS) ...


Depth-Resolved Structure Analysis of Cylindrical Microdomain in Block Copolymer Thin Film by Grazing-Incidence Small-Angle X-ray Scattering Utilizing Low-Energy X-rays

06-Nov-2015 | Itsuki Saito; Tsukasa Miyazaki; Katsuhiro Yamamoto, Macromolecules, 2015

Depth-resolved structure analysis of a polystyrene-b-poly(2-vinylpyridine) (S2VP) thin film (420 nm thick) was achieved by grazing-incidence small-angle X-ray scattering (GISAXS) utilizing low-energy X-rays (“tender” X-rays). In contrast to techniques utilizing hard X-rays, a gradual change of ...


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