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1,887 Newest Publications about the topic elongation


Inhibitors of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

14-11-2014 | Thomas A. Dineen; Kui Chen; Alan C. Cheng; Katayoun Derakhchan; Oleg Epstein; Joel Esmay; Dean Hickman; Chuck E. Kre ..., Journal of Medicinal Chemistry, 2014

We have previously shown that the aminooxazoline xanthene scaffold can generate potent and orally efficacious BACE1 inhibitors although certain of these compounds exhibited potential hERG liabilities. In this article, we describe 4-aza substitution on the xanthene core as a means to increase ...


Synthesis and properties of stereo mixtures of enantiomeric block copolymers of polylactide and aliphatic polycarbonate

13-11-2014 | Koji Kobayashi, Shuhei Kanmuri, Yoshiharu Kimura, Kazunari Masutani, Polymer International, 2014

Abstract A‐B‐A tri‐block copolymers of polylactides (PLA: A) and aliphatic polycarbonates (APC: B) were prepared by ring‐opening polymerization (ROP) of D‐ and L‐lactides with poly(hexamethylene carbonate) diol (PHMC) and poly(hexamethylene/ pentamethylene carbonate) diol (PHPC) as ...


Speed of Sound, Density, and Related Thermodynamic Excess Properties of Binary Mixtures of Butan-2-one with C1–C4 n-Alkanols and Chloroform

12-11-2014 | Mikhail A. Varfolomeev; Ksenia V. Zaitseva; Ilnaz T. Rakipov; Boris N. Solomonov; Wojciech Marczak, Journal of Chemical & Engineering Data, 2014

Densities and speeds of sound were measured for binary mixtures of butan-2-one with methanol, propan-1-ol, butan-1-ol, and chloroform at temperatures of 293.15–323.15 K and at atmospheric pressure, with the uncertainties of 0.05 kg·m–3 and 0.5 m·s–1, respectively. The molar excesses of volume, ...


An Integrated Imaging Probe Design: The Synthesis of 99mTc/Re‐Containing Macrocyclic Peptide Scaffolds

11-11-2014 | Jennifer L. Hickey, Emily J. Simpson, Jinqiang Hou, Leonard G. Luyt, Chemistry - A European Journal, 2014

Abstract β‐Sheets account for over 30 % of all secondary structural conformations found in proteins. The intramolecular hydrogen bonding that exists between the two peptide strands is imperative in maintaining this secondary structure. With the proper design, cyclic peptides may act as ...


Preparation and characterization of grafting styrene onto LLDPE by cyclohexane compatibilization in suspension polymerization

11-11-2014 | Fanyu Meng, Qiaoyun Zhang, Guozhi Wang, Hongyan Wang, Yan Gao, Journal of Applied Polymer Science, 2014

ABSTRACT A novel method of grafting styrene onto linear low‐density polyethylene (LLDPE) by suspension polymerization was systematically evaluated. Cyclohexane as a compatibilizer was introduced to swell and activate the surface of LLDPE molecular chain for amplifying the contact point of ...


Effect of Isomerism on Molecular Packing and Gas Transport Properties of Poly(benzoxazole-co-imide)s

11-11-2014 | Yongbing Zhuang; Jong Geun Seong; Yu Seong Do; Hye Jin Jo; Moon Joo Lee; Gang Wang; Michael D. Guiver; Young Moo Lee, Macromolecules, 2014

A facile approach to synthesize poly(benzoxazole-co-imide)s without thermal rearrangement at high temperature is proposed. Poly(benzoxazole-co-imide)s with improved mechanical and solution-processable properties were prepared through polycondensation of 4,4′-(hexafluoroisopropylidene) diphthalic ...


Mechanical, Optical, and Barrier Properties of Soy Protein Film As Affected by Phenolic Acid Addition

06-11-2014 | Anchana Insaward; Kiattisak Duangmal; Thanachan Mahawanich, Journal of Agricultural and Food Chemistry, 2014

This study aimed to explore the effect of phenolic acid addition on properties of soy protein film. Ferulic (FE), caffeic (CA), and gallic (GA) acids as well as their oxidized products were used in this study. Phenolic acid addition was found to have a significant effect (p ≤ 0.05) on the ...


Structure of the OsSERK2 leucine‐rich repeat extracellular domain

05-11-2014 | Ryan McAndrew, Rory N. Pruitt, Shizuo G. Kamita, Jose Henrique Pereira, Dipali Majumdar, Bruce D. Hammock, Paul D. A ..., Acta Crystallographica Section D, 2014

Somatic embryogenesis receptor kinases (SERKs) are leucine‐rich repeat (LRR)‐containing integral membrane receptors that are involved in the regulation of development and immune responses in plants. It has recently been shown that rice SERK2 (OsSERK2) is essential for XA21‐mediated resistance to ...


Understanding external plasticization of melt extruded PHBV–wheat straw fibers biodegradable composites for food packaging

05-11-2014 | Lucrezia Martino, Marie‐Alix Berthet, Hélène Angellier‐Coussy, Nathalie Gontard, Journal of Applied Polymer Science, 2014

ABSTRACT The objective of this work is to get further knowledge on the external plasticization mechanisms of melt extruded polyhydroxyl‐3‐butyrate‐co−3‐valerate (PHBV) when combined with wheat straw fibers (WSF). Different types of biodegradable substances, all authorized for food contact ...


Compatibilization of PUR/PVAC polymer blend by addition of calcium carbonate filler

04-11-2014 | Domagoj Vrsaljko, Xujin Bao, Polymer Composites, 2014

The influence of untreated and stearic acid surface pretreated calcium carbonate (CaCO3) nanofiller (U1 – untreated CaCO3 and U1S2 – stearic acid treated CaCO3) on the properties of polyurethane/poly(vinyl acetate) (PUR/PVAC) polymer blends was investigated. Adhesion between fillers and polymers ...


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