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14,493 Newest Publications about the topic expression

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Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs

22-May-2016 | Author(s): Satish K. Chitneni, Zachary J. Reitman, David M. Gooden, Hai Yan, Michael R. Zalutsky, European Journal of Medicinal Chemistry, 2016

Publication date: 25 August 2016 Source:European Journal of Medicinal Chemistry, Volume 119 Author(s): Satish K. Chitneni, Zachary J. Reitman, David M. Gooden, Hai Yan, Michael R. Zalutsky Introduction Malignant gliomas frequently harbor mutations in the isocitrate dehydrogenase 1 ...

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Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells

22-May-2016 | Author(s): Necla Kulabaş, Esra Tatar, Özlem Bingöl Özakpınar, Derya Özsavcı, Christophe Pannecouque, Erik ..., European Journal of Medicinal Chemistry, 2016

Publication date: 4 October 2016 Source:European Journal of Medicinal Chemistry, Volume 121 Author(s): Necla Kulabaş, Esra Tatar, Özlem Bingöl Özakpınar, Derya Özsavcı, Christophe Pannecouque, Erik De Clercq, İlkay Küçükgüzel In this study, a series of thiosemicarbazide ...

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How much successful are the medicinal chemists in modulation of SIRT1: A critical review

22-May-2016 | Author(s): Ashwani Kumar, Shilpi Chauhan, European Journal of Medicinal Chemistry, 2016

Publication date: 25 August 2016 Source:European Journal of Medicinal Chemistry, Volume 119 Author(s): Ashwani Kumar, Shilpi Chauhan Silent information regulator two homologue one (SIRT1) is the most widely studied member of the sirtuin family related to histone deacetylases class III ...

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IJMS, Vol. 17, Pages 787: Functional and Biochemical Characterization of Three Recombinant Human Glucose-6-Phosphate Dehydrogenase Mutants: Zacatecas, Vanua-Lava and Viangchan

21-May-2016 | Gómez-Manzo, Saúl ; Marcial-Quino, Jaime ; Vanoye-Carlo, America ; Serrano-Posada, Hugo ; González-Valdez, Abigail ; ..., International Journal of Molecular Sciences, 2016

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. In order to understand the effect of the mutations in G6PD ...

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IJMS, Vol. 17, Pages 790: Variability in Immunohistochemical Detection of Programmed Death Ligand 1 (PD-L1) in Cancer Tissue Types

21-May-2016 | Scognamiglio, Giosuè ; De Chiara, Anna ; Di Bonito, Maurizio ; Tatangelo, Fabiana ; Losito, Nunzia Simona; Anniciell ..., International Journal of Molecular Sciences, 2016

In normal cell physiology, programmed death 1 (PD-1) and its ligand, PD-L1, play an immunoregulatory role in T-cell activation, tolerance, and immune-mediated tissue damage. The PD-1/PD-L1 pathway also plays a critical role in immune escape of tumor cells and has been demonstrated to correlate ...

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Epigallocatechin gallate sensitizes cisplatin‐resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling

20-May-2016 | Chien‐Han Yuan, Chi‐Ting Horng, Chiu‐Fang Lee, Ni‐Na Chiang, Fuu‐Jen Tsai, Chi‐Cheng Lu, Jo‐Hua Chiang, Yuan‐Man Hsu ..., Environmental Toxicology, 2016

Epigallocatechin gallate (EGCG) is a green tea polyphenol that presents anticancer activities in multiple cancer cells, but no available report was addressed for the underling molecular mechanism of cytotoxic impacts on drug‐resistant oral squamous cell carcinoma cells. In the present study, the ...

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Autocrine‐Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries

20-May-2016 | Hongkai Zhang, Mingjuan Du, Jia Xie, Xiao Liu, Jingying Sun, Wei Wang, Xiu Xin, Lourival D. Possani, Kyungmoo Yea, R ..., Angewandte Chemie International Edition, 2016

Abstract Animal venoms represent a rich source of pharmacologically active peptides that interact with ion channels. However, a challenge to discovering drugs remains because of the slow pace at which venom peptides are discovered and refined. An efficient autocrine‐based high‐throughput ...

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IJMS, Vol. 17, Pages 776: Integrated Analysis of Expression Profile Based on Differentially Expressed Genes in Middle Cerebral Artery Occlusion Animal Models

20-May-2016 | Zhou, Huaqiang ; Qiu, Zeting ; Gao, Shaowei ; Chen, Qinchang ; Li, Si ; Tan, Wulin ; Liu, Xiaochen ; Wang, Zhongxing, International Journal of Molecular Sciences, 2016

Stroke is one of the most common causes of death, only second to heart disease. Molecular investigations about stroke are in acute shortage nowadays. This study is intended to explore a gene expression profile after brain ischemia reperfusion. Meta-analysis, differential expression analysis, and ...

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IJMS, Vol. 17, Pages 786: Expression Patterns and Functional Novelty of Ribonuclease 1 in Herbivorous Megalobrama amblycephala

20-May-2016 | Liu, Han ; Wang, Weimin, International Journal of Molecular Sciences, 2016

Ribonuclease 1 (RNase1) is an important digestive enzyme that has been used to study the molecular evolutionary and plant-feeding adaptation of mammals. However, the expression patterns and potential biological function of RNase1 in herbivorous fish is not known. Here, we identified RNase1 from ...

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Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells

20-May-2016 | PSS Rao; Anusha Ande; Namita Sinha; Anil Kumar; Santosh Kumar, PLoS ONE, 2016

by PSS Rao, Anusha Ande, Namita Sinha, Anil Kumar, Santosh Kumar While cigarette smoking is prevalent amongst HIV-infected patients, the effects of cigarette smoke constituents in cells of myeloid lineage are poorly known. Recently, we have shown that nicotine induces oxidative stress through ...

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