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12,587 Newest Publications about the topic expression


Endocrine Modulation of Olfactory Responsiveness: Effects of the Orexigenic Hormone Ghrelin

01-Sep-2015 | Diana Loch; Heinz Breer; Jörg Strotmann, Chemical Senses, 2015

Finding food sources is a prerequisite for an acute food intake. This process is initiated by ghrelin released from X/A-like cells of the gastrointestinal tract. Because food finding often depends on olfaction, the question arises whether ghrelin may affect the responsiveness of the olfactory ...


Down‐regulation of BDNF in cell and animal models increases striatal‐enriched protein tyrosine phosphatase 61 (STEP61) levels

28-Aug-2015 | Jian Xu, Pradeep Kurup, Garikoitz Azkona, Tyler D. Baguley, Ana Saavedra, Angus C. Nairn, Jonathan A. Ellman, Esther ..., Journal of Neurochemistry, 2015

Abstract Brain‐derived neurotrophic factor (BDNF) regulates synaptic strengthening and memory consolidation, and altered BDNF expression is implicated in a number of neuropsychiatric and neurodegenerative disorders. BDNF potentiates NMDAR function through activation of Fyn and ERK1/2. ...



28-Aug-2015 | Tatjana V. Nikolić, Jelena Purać, Snežana Orčić, Danijela Kojić, Dragana Vujanović, Zoran Stanimirović, Ivan Gržetić ..., Archives of Insect Biochemistry and Physiology, 2015

Understanding the cellular stress response in honey bees will significantly contribute to their conservation. The aim of this study was to analyze the response of the antioxidative enzymes superoxide dismutase and catalase in honey bees related to the presence of toxic metals in different ...


Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis

27-Aug-2015 | Hubert J.M. Smeets, Suzanne C.E.H. Sallevelt, Jos C.F.M. Dreesen, Christine E.M. Die‐Smulders, Irenaeus F.M. Coo, Annals of the New York Academy of Sciences, 2015

Mitochondrial disorders are among the most common inborn errors of metabolism; at least 15% are caused by mitochondrial DNA (mtDNA) mutations, which occur de novo or are maternally inherited. For familial heteroplasmic mtDNA mutations, the mitochondrial bottleneck defines the mtDNA mutation load ...


Aspalathin improves glucose and lipid metabolism in 3T3‐L1 adipocytes exposed to palmitate

27-Aug-2015 | Sithandiwe E. Mazibuko, Elizabeth Joubert, Rabia Johnson, Johan Louw, Andrew R. Opoku, Chisto J.F Muller, Molecular Nutrition & Food Research, 2015

Scope Saturated free fatty acids (SFFAs), such as palmitate, are associated with insulin resistance. This study aimed to establish if an aspalathin‐enriched green rooibos extract (GRE) and, its major flavone constituents, aspalathin (ASP) could contribute significantly to the amelioration of ...


MiR‐124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine‐tuning UHRF1

27-Aug-2015 | Xinsheng Wang, Qiaoli Wu, Bin Xu, Pengfei Wang, Weijia Fan, Ying Cai, Xinquan Gu, Fanping Meng, FEBS Journal, 2015

Summary UHRF1, an epigenetic factor, is implicated in various cellular processes of tumorigenesis. However, the modulation UHRF1 expression in human bladder cancer at posttranscriptional levels remains unclear. Here, we report that miR‐124 suppresses expression of UHRF1 to affect the ...


MZDASoft: a software architecture that enables large‐scale comparison of protein expression levels over multiple samples based on liquid chromatography/tandem mass spectrometry

26-Aug-2015 | Mehrab Ghanat Bari, Nelson Ramirez, Zhiwei Wang, Jianqiu (Michelle) Zhang, Rapid Communications in Mass Spectrometry, 2015

Rationale Without accurate peak linking/alignment, only the expression levels of a small percentage of proteins can be compared across multiple samples in Liquid Chromatography/Mass Spectrometry/Tandem Mass Spectrometry (LC/MS/MS) due to the selective nature of tandem MS peptide ...


Oxidative stress and endocytosis are involved in upregulation of interleukin‐8 expression in airway cells exposed to PM2.5

25-Aug-2015 | Zhen Yan, Jia Wang, Juan Li, Nan Jiang, Ruiqin Zhang, Weichao Yang, Wu Yao, Weidong Wu, Environmental Toxicology, 2015

ABSTRACT Inhaled PM2.5 (particulate matter with an aerodynamic diameter of 2.5 μm or less) can induce lung inflammation through released inflammatory mediators from airway cells, such as interleukin‐8 (IL‐8) and tumor necrosis factor alpha (TNF‐α). However, the mechanisms underlying ...


Hyperlipidemia‐induced hepatic and small intestine ER stress and decreased paraoxonase 1 expression and activity is associated with HDL dysfunction in Syrian hamsters

25-Aug-2015 | Camelia S. Stancu, Mihaela G. Carnuta, Gabriela M. Sanda, Laura Toma, Mariana Deleanu, Loredan S. Niculescu, Shlomo ..., Molecular Nutrition & Food Research, 2015

Scope We aimed at investigating the mechanisms linking hyperlipidemia (HL) with dysfunctional HDL and its main antioxidant enzyme, paraoxonase1 (PON1). PON1 expression and activity was determined in the small intestine, liver and sera of normal and HL hamsters and associated with the ER stress ...


In Search of Selective 11β-HSD Type 1 Inhibitors without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening

23-Aug-2015 | Author(s): Harun Patel, Kiran Dhangar, Yogesh Sonawane, Sanjay Surana, Rajshekhar Karpoormath, Neeta Tha ..., Arabian Journal of Chemistry, 2015

Publication date: Available online 21 August 2015 Source:Arabian Journal of Chemistry Author(s): Harun Patel, Kiran Dhangar, Yogesh Sonawane, Sanjay Surana, Rajshekhar Karpoormath, Neeta Thapliyal, Mahamadhanif Shaikh, Malleshappa Noolvi, Rakesh Jagtap Over expression of ...


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