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Novel Protein Arginine Methyltransferase 8 Isoform is Essential for Cell Proliferation

06-Feb-2016 | Sarah Hernandez, Tanja Dominko, Journal of Cellular Biochemistry, 2016

ABSTRACT Identification of molecular mechanisms that regulate cellular replicative lifespan is needed to better understand the transition between a normal and a neoplastic cell phenotype. We have previously reported that low oxygen‐mediated activity of FGF2 leads to an increase in cellular ...


Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High‐Fat Diet‐Induced Obese Mice

06-Feb-2016 | Yo‐Han Han, Ji‐Ye Kee, Jinbong Park, Hye‐Lin Kim, Mi‐Young Jeong, Dae‐Seung Kim, Yong‐Deok Jeon, Yunu Jung, Dong‐Hyu ..., Journal of Cellular Biochemistry, 2016

ABSTRACT Although arctigenin (ARC) has been reported to have some pharmacological effects such as anti‐inflammation, anti‐cancer, and antioxidant, there have been no reports on the anti‐obesity effect of ARC. The aim of this study is to investigate whether ARC has an anti‐obesity effect and ...


The role of the Wnt/β‐catenin‐Annexin A1 pathway in the process of sevoflurane‐induced cognitive dysfunction

06-Feb-2016 | Nan Hu, Chao Wang, Yuxin Zheng, Jiying Ao, Chao Zhang, Keliang Xie, Yize Li, Haiyun Wang, Yonghao Yu, Guolin Wang, Journal of Neurochemistry, 2016

Abstract Postoperative cognitive decline (POCD) is a common geriatric complication, and sevoflurane is a widely accepted inducer of POCD. Although the aetiology of POCD is not clear, a breach in the blood‐brain barrier (BBB) is involved in early POCD. Annexin A1 has shown protective effects on ...


Pituitary Adenylate Cyclase‐Activating Polypeptide Orchestrates Neuronal Regulation of the Astrocytic Glutamate Releasing Mechanism System xc

06-Feb-2016 | Linghai Kong, Rebecca Albano, Aric Madayag, Nicholas Raddatz, John R. Mantsch, SuJean Choi, Doug Lobner, David A. Baker, Journal of Neurochemistry, 2016

Abstract Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes. Hence, it is critical to better understand how neurons and astrocytes interact to coordinate the cellular regulation of glutamate signaling. In these studies, we used rat cortical cell cultures ...


IJMS, Vol. 17, Pages 221: Wnt16 Signaling Is Required for IL-1β-Induced Matrix Metalloproteinase-13-Regulated Proliferation of Human Stem Cell-Derived Osteoblastic Cells

06-Feb-2016 | Ozeki, Nobuaki ; Mogi, Makio ; Hase, Naoko ; Hiyama, Taiki ; Yamaguchi, Hideyuki ; Kawai, Rie ; Kondo, Ayami ; Nakat ..., International Journal of Molecular Sciences, 2016

We established a differentiation method for homogeneous α7 integrin-positive human skeletal muscle stem cell (α7+hSMSC)-derived osteoblast-like (α7+hSMSC-OB) cells, and found that interleukin (IL)-1β induces matrix metalloproteinase (MMP)-13-regulated proliferation of these cells. These data ...


IJMS, Vol. 17, Pages 226: Chemically Induced Reprogramming of Somatic Cells to Pluripotent Stem Cells and Neural Cells

06-Feb-2016 | Biswas, Dhruba ; Jiang, Peng, International Journal of Molecular Sciences, 2016

The ability to generate transplantable neural cells in a large quantity in the laboratory is a critical step in the field of developing stem cell regenerative medicine for neural repair. During the last few years, groundbreaking studies have shown that cell fate of adult somatic cells can be ...


Monitoring Tyrosinase Expression in Non‐metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy

05-Feb-2016 | Tzu‐En Lin, Alexandra Bondarenko, Andreas Lesch, Horst Pick, Fernando Cortés‐Salazar, Hubert H. Girault, Angewandte Chemie International Edition, 2016

Abstract Although tremendous progress has been made in the diagnosis of melanoma, the identification of different stages of malignancy in a reliable way remains challenging. Current strategies rely on optical monitoring of the concentration and spatial distribution of specific biomarkers. ...


A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

05-Feb-2016 | Anirudra Parajuli, Daniel H. Kwak, Luca Dalponte, Niina Leikoski, Tomas Galica, Ugochukwu Umeobika, Laurent Tremblea ..., Angewandte Chemie International Edition, 2016

Abstract Cyanobactins are a rapidly growing family of linear and cyclic peptides produced by cyanobacteria. Kawaguchipeptins A and B, two macrocyclic undecapeptides reported earlier from Microcystis aeruginosa NIES‐88, are shown to be products of the cyanobactin biosynthetic pathway. The 9 kb ...


High dietary cholesterol intake during lactation promotes development of fatty liver in offspring of mice

05-Feb-2016 | Tsuyoshi Tsuduki, Kazushi Yamamoto, Yu Hatakeyama, Yu Sakamoto, Molecular Nutrition & Food Research, 2016

Scope : We have previously demonstrated in mice that a maternal high fat diet during lactation enhances the susceptibility of offspring to obesity and fatty liver. A causative molecule, however, is yet to be identified. Therefore, we examined the role of cholesterol, the dietary intake of ...


IJMS, Vol. 17, Pages 212: The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology

05-Feb-2016 | Liu, Qiang ; Niu, Na ; Wada, Youichiro ; Liu, Ju, International Journal of Molecular Sciences, 2016

Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21Cip1/Waf1. Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological ...


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