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14,706 Newest Publications about the topic expression


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Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor‐α‐dependent gene expression

25-Jun-2016 | Wei Zhang, Jo‐Hsin Chen, Irene Aguilera‐Barrantes, Chung‐Wai Shiau, Xiugui Sheng, Li‐Shu Wang, Gary D. Stoner, Yi‐We ..., Molecular Nutrition & Food Research, 2016

Abstract Scope : Obese and overweight women are at high risk of developing endometrial cancer; indeed, many of endometrial cancer patients are obese. The increased number and size of adipocytes due to obesity elevate levels of circulating estrogens that stimulate cell proliferation in the ...


IJMS, Vol. 17, Pages 1008: Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes

25-Jun-2016 | Costa, Valerio ; Federico, Antonio ; Pollastro, Carla ; Ziviello, Carmela ; Cataldi, Simona ; Formisano, Pietro ; Ci ..., International Journal of Molecular Sciences, 2016

Type 2 diabetes (T2D) is one of the most frequent mortality causes in western countries, with rapidly increasing prevalence. Anti-diabetic drugs are the first therapeutic approach, although many patients develop drug resistance. Most drug responsiveness variability can be explained by genetic ...


Gremlin2 Suppression Increases the BMP‐2‐Induced Osteogenesis of Human Bone‐Marrow‐Derived Mesenchymal Stem Cells via the BMP‐2/Smad/Runx2 Signaling Pathway

23-Jun-2016 | Cheng‐Long Wang, Fei Xiao, Chuan‐Dong Wang, Jun‐Feng Zhu, Chao Shen, Bin Zuo, Hui Wang, De Li, Xu‐Yi Wang, Wei‐Jia F ..., Journal of Cellular Biochemistry, 2016

ABSTRACT Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP‐2 pathway has been well‐defined as a vital positive modulator of bone homeostasis. Gremlin2 (Grem2) is a bone ...


ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells

23-Jun-2016 | Satoru Onizuka, Takanori Iwata, Sung‐Joon Park, Kenta Nakai, Masayuki Yamato, Teruo Okano, Yuichi Izumi, Journal of Cellular Biochemistry, 2016

Abstract Human multipotent mesenchymal stromal cells (hMSCs) possess the ability to differentiate into osteoblasts, and they can be utilized as a source for bone regenerative therapy. Osteoinductive pretreatment, which induces the osteoblastic differentiation of hMSCs in vitro, has been ...


IJMS, Vol. 17, Pages 993: Cytotoxicity and Apoptotic Effects of Polyphenols from Sugar Beet Molasses on Colon Carcinoma Cells in Vitro

23-Jun-2016 | Chen, Mingshun ; Zhao, Zhengang ; Yu, Shujuan, International Journal of Molecular Sciences, 2016

Three polyphenols were isolated and purified from sugar beet molasses by ultrasonic-aid extraction and various chromatographic techniques, and their structures were elucidated by spectral analysis. Cytotoxicity and the molecular mechanism were measured by methyl thiazolyl tetrazolium (MTT) assay, ...


Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors

22-Jun-2016 | Liping H. Pettus; Kristin L. Andrews; Shon K. Booker; Jie Chen; Victor J. Cee; Frank Chavez, Jr.; Yuping Chen; Heath ..., Journal of Medicinal Chemistry, 2016

The high expression of proviral insertion site of Moloney murine leukemia virus kinases (Pim-1, -2, and -3) in cancers, particularly the hematopoietic malignancies, is believed to play a role in promoting cell survival and proliferation while suppressing apoptosis. The three isoforms of Pim ...


DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis

21-Jun-2016 | Kohinoor Kaur, Priyanka Kumari, Saurabh Sharma, Snigdha Sehgal, Jaya Sivaswami Tyagi, FEBS Journal, 2016

Abstract Two‐component systems, comprising histidine kinases and response regulators, empower bacteria to sense and adapt to diverse environmental stresses. Some histidine kinases are bifunctional; their phosphorylation (kinase) and dephosphorylation (phosphatase) activities towards their ...


Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B

21-Jun-2016 | Baojian Guo; Chengyou Zheng; Wei Cai; Jiehong Cheng; Hongyu Wang; Haitao Li; Yewei Sun; Wei Cui; Yuqiang Wang; Yifan ..., Journal of Agricultural and Food Chemistry, 2016

Chrysin, a flavonoid compound existing in several plants, is applied as a dietary supplement because of its beneficial effects on general human health and alleviation of neurological disorders. However, mechanisms underlying neuroprotection of chrysin has not been fully elucidated, and the ...


Genome‐wide identification, annotation and expression profile analysis of SnRK2 gene family in grapevine

20-Jun-2016 | J.‐Y. Liu, N.‐N. Chen, Z.‐M. Cheng, J.‐S. Xiong, Australian Journal of Grape and Wine Research, 2016

Abstract Background and Aims Protein kinases are widely involved in the response in plants to external environment stress signals. Sucrose non‐fermenting 1‐related protein kinase 2 (SnRK2) is an important class of plant‐specific protein kinases that plays a crucial role in abscisic acid ...


Comparative Transcriptome Analysis of Two Ipomoea aquatica Forsk. Cultivars Targeted To Explore Possible Mechanism of Genotype-Dependent Accumulation of Cadmium

20-Jun-2016 | Ying-Ying Huang; Chuang Shen; Jing-Xin Chen; Chun-Tao He; Qian Zhou; Xiao Tan; Jian-Gang Yuan; Zhong-Yi Yang, Journal of Agricultural and Food Chemistry, 2016

A low-shoot-Cd (QLQ) and a high-shoot-Cd cultivar (T308) of water spinach (Ipomoea aquatica Forsk.) were used to investigate molecular mechanism of the genotype difference in cadmium (Cd) accumulation. RNA-Seq under 9 and 72 h cadmium exposures (5 mg L–1) were undertaken to explore Cd induced ...


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