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11,129 Newest Publications about the topic expression

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In vivo rapid gene delivery into postmitotic neocortical neurons using iontoporation

01-01-2015 | Andres De la Rossa; Denis Jabaudon, Nature Protocols, 2015

Nature Protocols 10, 25 (2015). doi:10.1038/nprot.2015.001 Authors: Andres De la Rossa & Denis Jabaudon This protocol describes a method for directing the expression of genes of interest into postmitotic neocortical neurons in vivo. Microinjection of a DNA plasmid-amphiphilic ...

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Recent Advances in Non-Steroidal FXR Antagonists Development for Therapeutic Applications

16-12-2014 | Huang, Huang; Xu, Yong; Zhu, Jin; Li, Jian, Current Topics in Medicinal Chemistry, 2014

Abstract: Farnesoid X receptor (FXR, NR1H4), a nuclear receptor (NR) highly expressed in the liver, intestine, kidney, adrenal glands and other cholesterol-rich tissues, functions as the master regulator for bile acid homeostasis. FXR, which regulates the expression of genes encoding ...

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Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase

15-12-2014 | Dodia R; Meunier B; Kay CWM; Rich PR, Biochemical Journal, 2014

Subunit 5 of Saccharomyces cerevisiae cytochrome c oxidase (CcO) is essential for assembly and has two isoforms, 5A and 5B. 5A is expressed under normoxic conditions, whereas 5B is expressed at very low oxygen tensions. As a consequence, COX5A-deleted strains (Δcox5A) have no or only low levels ...

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A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation

15-12-2014 | Huttner S; Veit C; Vavra U; Schoberer J; Dicker M; Maresch D; Altmann F; Strasser R, Biochemical Journal, 2014

N-glycosylation of proteins plays an important role in the determination of the fate of newly synthesized glycoproteins in the endoplasmic reticulum (ER). Specific oligosaccharide structures recruit molecular chaperones that promote folding or mannose-binding lectins that assist in the clearance ...

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Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175

15-12-2014 | Author(s): Luca Piemontese , Giuseppe Fracchiolla , Antonio Carrieri , Mariagiovanna Parente , Antonio Laghezza ..., European Journal of Medicinal Chemistry, 2014

Publication date: 27 January 2015 Source:European Journal of Medicinal Chemistry, Volume 90 Author(s): Luca Piemontese , Giuseppe Fracchiolla , Antonio Carrieri , Mariagiovanna Parente , Antonio Laghezza , Giuseppe Carbonara , Sabina Sblano , Marilena Tauro , Federica Gilardi , ...

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Total Synthesis of Albicidin: A Lead Structure from Xanthomonas albilineans for Potent Antibacterial Gyrase Inhibitors

12-12-2014 | Julian Kretz, Dennis Kerwat, Vivien Schubert, Stefan Grätz, Alexander Pesic, Siamak Semsary, Stéphane Cociancich, Mo ..., Angewandte Chemie International Edition, 2014

Abstract The peptide antibiotic albicidin, which is synthesized by the plant pathogenic bacterium Xanthomonas albilineans, displays remarkable antibacterial activity against various Gram‐positive and Gram‐negative microorganisms. The low amounts of albicidin obtainable from the producing ...

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Proteins: Materials Fabrication from Native and Recombinant Thermoplastic Squid Proteins (Adv. Funct. Mater. 47/2014)

12-12-2014 | Abdon Pena‐Francesch, Sergio Florez, Huihun Jung, Aswathy Sebastian, Istvan Albert, Wayne Curtis, Melik C. Demirel, Advanced Functional Materials, 2014

Squid ring teeth complex extracted from Loligo vulgaris shows reversible solid to melt phase transition on page 7401. M. C. Demirel and team show how the direct extraction or recombinant expression of protein based thermoplastics opens up new avenues for materials fabrication and synthesis, ...

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Anthocyanin Accumulation and Transcriptional Regulation of Anthocyanin Biosynthesis in Purple Bok Choy (Brassica rapa var. chinensis)

12-12-2014 | Yanjie Zhang; Guoping Chen; Tingting Dong; Yu Pan; Zhiping Zhao; Shibing Tian; Zongli Hu, Journal of Agricultural and Food Chemistry, 2014

Bok choy (Brassica rapa var. chinensis) is an important dietary vegetable cultivated and consumed worldwide for its edible leaves. The purple cultivars rich in health-promoting anthocyanins are usually more eye-catching and valuable. Fifteen kinds of anthocyanins were separated and identified ...

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IJMS, Vol. 15, Pages 23212-23226: Sodium Hydrosulfide Prevents Myocardial Dysfunction through Modulation of Extracellular Matrix Accumulation and Vascular Density

12-12-2014 | Pan, Li-Long ; Wang, Xian-Li ; Wang, Xi-Ling ; Zhu, Yi-Zhun, International Journal of Molecular Sciences, 2014

The aim was to examine the role of exogenous hydrogen sulfide (H2S) on cardiac remodeling in post-myocardial infarction (MI) rats. MI was induced in rats by ligation of coronary artery. After treatment with sodium hydrosulfide (NaHS, an exogenous H2S donor, 56 μM/kg·day) for 42 days, the effects ...

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A Novel Role for SIRT-1 in L-Arginine Protection against STZ Induced Myocardial Fibrosis in Rats

12-12-2014 | Sherine M. Rizk et al., PLoS ONE, 2014

by Sherine M. Rizk, Shohda A. El-Maraghy, Noha N. Nassar Background L-arginine (L-ARG) effectively protects against diabetic impediments. In addition, silent information regulator (SIRT-1) activators are emerging as a new clinical concept in treating diabetic complications. Accordingly, this ...

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