01-06-2013 | Lane DJR; Huang ML-H; Richardson DR, Biochemical Journal, 2013

Does the hormone of iron metabolism, hepcidin, exhibit 'self-control'? Hepcidin is a small, disulfide-rich peptide synthesized by the liver, which plays a keystone role in regulating systemic iron metabolism in mammals. Hepcidin acts by binding and triggering the lysosomal degradation of the ...

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22-05-2013 | Vitaliy A. Morozov, Physical Chemistry Chemical Physics, 2013

A statistical theory of temperature-induced spin-crossover-like transitions has been developed for spin chains with a few exchange clusters in a unit cell. Using static magnetic susceptibility measurements, a general expression for the effective magnetic moment μeff of exchange clusters is ...

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18-05-2013 | Neeraja Dharmaraj, Brian J. Engel, Daniel D. Carson, Journal of Cellular Biochemistry, 2013

Abstract MUC1 is a large cell surface mucin glycoprotein that plays diverse roles in both normal and tumor cell biology. These roles include mucosal hydration and protection, inhibition of embryo implantation, protection of tumor cells from the immune system and reduction of cytotoxic ...

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17-05-2013 | Sylvia Christakos, Martin Hewison, David G. Gardner, Carol L. Wagner, Igor N. Sergeev, Erica Rutten, Anastassios G. ..., Annals of the New York Academy of Sciences, 2013

In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone ...

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17-05-2013 | Vladimira Horova, Nada Hradilova, Iva Jelinkova, Michal Koc, Jan Svadlenka, Jan Brazina, Martin Klima, Josef Slavik, ..., FEBS Journal, 2013

Abstract Tumour necrosis factor‐Related Apoptosis Inducing Ligand (TRAIL), a membrane‐bound ligand from the TNF family, has attracted significant attention due to its rather specific and effective ability to induce apoptotic death in various types of cancer cells via binding to and ...

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17-05-2013 | Shashi Kiran, Nirupa ma Chatterjee, Sapna Singh, Sunil C. Kaul, Renu Wadhwa, Gayatri Ramakrishna, FEBS Journal, 2013

Abstract Sirtuins belong to a class of NAD‐dependent deacetylases and consists of seven distinct isoforms of which SIRT7 is the least studied member. In the present study, the subcellular expression of SIRT7 in primary fibroblasts undergoing senescence was evaluated by immunocytochemistry ...

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17-05-2013 | Wang, Jie ; Jiang, Zong-Pei ; Su, Ning ; Fan, Jin-Jin ; Ruan, Yi-Ping ; Peng, Wen-Xing ; Li, Ya-Fang ; Yu, Xue-Qing, International Journal of Molecular Sciences, 2013

It has been confirmed that alternatively activated macrophages (M2) participate in tissue remodeling and fibrosis occurrence, but the effect of M2 on peritoneal fibrosis related to peritoneal dialysis (PD) hasn’t been elucidated. This study was therefore conducted to assess the association ...

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17-05-2013 | English, Diana P.; Santin, Alessandro D., International Journal of Molecular Sciences, 2013

Claudins are a family of tight junction proteins regulating paracellular permeability and cell polarity with different patterns of expression in benign and malignant human tissues. There are approximately 27 members of the claudin family identified to date with varying cell and ...

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17-05-2013 | Max C. Liebau et al., PLoS ONE, 2013

by Max C. Liebau, Fabian Braun, Katja Höpker, Claudia Weitbrecht, Valerie Bartels, Roman-Ulrich Müller, Susanne Brodesser, Moin A. Saleem, Thomas Benzing, Bernhard Schermer, Markus Cybulla, Christine E. Kurschat Fabry’s disease results from an inborn error of glycosphingolipid metabolism ...

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17-05-2013 | Junko Matsuoka et al., PLoS ONE, 2013

by Junko Matsuoka, Masakazu Yashiro, Yosuke Doi, Yuhiko Fuyuhiro, Yukihiro Kato, Osamu Shinto, Satoru Noda, Shinichiro Kashiwagi, Naoki Aomatsu, Toshiki Hirakawa, Tsuyoshi Hasegawa, Kiyoshi Shimizu, Toshiyuki Shimizu, Atsushi Miwa, Nobuya Yamada, Tetsuji Sawada, Kosei Hirakawa Epithelial ...

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