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The transition path time distribution and the transition path free energy barrier

22-Sep-2016 | E Pollak, Physical Chemistry Chemical Physics, 2016

The recent experimental measurement of the transition path time distributions of proteins present theory with several challenges. Foremost, why do the fits of the experimental data to a theoretical expression lead to barrier heights which are much lower than the free energies of activation of the ...


Coupled Molecular Design Diagrams to Guide Safer Chemical Design with Reduced Likelihood of Perturbing the NRF2-ARE Antioxidant Pathway and Inducing Cytotoxicity

22-Sep-2016 | Longzhu Shen; Fjodor Melnikov; John Roethle; Aditya Gudibanda; Richard Judson; Julie Zimmerman; Paul Anastas, Green Chemistry, 2016

The NRF2-ARE antioxidant pathway is an important biological sensing and regulating system that responds to xenochemicals. NRF2 senses chemically-caused production of reactive oxygen species (ROS) and upregulates the expression of a wide array of genes to counteract oxidative or electrophilic ...


Förster Resonance Energy Transfer to impart Signal-on and -off capabilities in a single microRNA biosensor

22-Sep-2016 | Nicholas E. Larkey; Lulu Zhang; Shan S Lansing; Victoria Tran; Victoria L. Seewaldt; Sean Burrows, Analyst, 2016

Many studies found that over- or under-expression of biomolecules called microRNAs (miRNA) regulates several diseases. Biosensors are in need to visually identify the relative expression level to determine the direction these miRNA change in cells and tissues. Our established reporter+probe miRNA ...


Molecules, Vol. 21, Pages 1244: Chemical Composition and in Vitro Antimicrobial, Cytotoxic, and Central Nervous System Activities of the Essential Oils of Citrus medica L. cv. ‘Liscia’ and C. medica cv. ‘Rugosa’ Cultivated in Southern Italy

18-Sep-2016 | Aliberti, Luigi ; Caputo, Lucia ; De Feo, Vincenzo ; De Martino, Laura ; Nazzaro, Filomena ; Souza, Lucéia Fátima, Molecules, 2016

Citrus medica cv. ‘liscia’ and C. medica cv. ‘rugosa’ are two taxa of citron, belonging to the biodiversity of South Italy, in particular of Amalfi Coast, in the Campania region. The chemical composition of the essential oils (EOs) from fruit peels of both C. medica cultivars was studied by gas ...


Spacial and Temporal Paterns of Gene Expression After Cardiac MEK1 Gene Transfer Improve Post‐Infarction Remodeling without Inducing Global Hypertrophy

17-Sep-2016 | Yanying Fan, Yi‐Lin Yang, Che‐Chung Yeh, Michael J. Mann, Journal of Cellular Biochemistry, 2016

Abstract Alteration of mitogen activated protein (MAP) kinase signaling in transgenic mice can ameliorate post‐myocardial infarction (MI) remodeling. However, pre‐existing changes in transgenic hearts and clinically unrealistic transgene expression likely affect the response to injury; it is ...


Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson Disease

17-Sep-2016 | Daniel Komnig, Jörg B. Schulz, Arno Reich, Björn H. Falkenburger, Journal of Neurochemistry, 2016

Abstract The death receptor Fas/CD95 mediates apoptotic cell death in response to external stimuli. In neurons, Fas‐induced apoptosis is prevented by Fas‐apoptotic inhibitory molecule 2 (Faim2). Mice lacking Faim2 showed increased neurodegeneration in animal models of stroke and bacterial ...


IJMS, Vol. 17, Pages 1571: Immunoglobulin Tau Heavy Chain (IgT) in Flounder, Paralichthys olivaceus: Molecular Cloning, Characterization, and Expression Analyses

17-Sep-2016 | Du, Yang ; Tang, Xiaoqian ; Zhan, Wenbin ; Xing, Jing ; Sheng, Xiuzhen, International Journal of Molecular Sciences, 2016

Immunoglobulin tau (IgT) is a new teleost immunoglobulin isotype, and its potential function in adaptive immunity is not very clear. In the present study, the membrane-bound and secreted IgT (mIgT and sIgT) heavy chain genes were cloned for the first time and characterized in flounder ...


Dexamethasone improves redox state in Ataxia Telangiectasia cells by promoting NRF2‐mediated antioxidant response

16-Sep-2016 | Sara Biagiotti, Michele Menotta, Sara Orazi, Chiara Spapperi, Serena Brundu, Alessandra Fraternale, Marzia Bianchi, ..., FEBS Journal, 2016

Abstract Ataxia Telangiectasia (A‐T) is a rare incurable neurodegenerative disease caused by biallelic mutations in the ATM gene. The lack of a functional ATM kinase leads to a pleiotropic phenotype, and oxidative stress is thought to have a crucial role in the complex physiopathology. ...


Probing Low‐Copy‐Number Proteins in a Single Living Cell

16-Sep-2016 | Jia Liu, Danyang Yin, Shuangshou Wang, Hong‐Yuan Chen, Zhen Liu, Angewandte Chemie International Edition, 2016

Abstract Single‐cell analysis techniques are essential for understanding the microheterogeneity and functions of cells. Low‐copy‐number proteins play important roles in cell functioning, but their measurement in single cells remains challenging. Herein, we report an approach, called plasmonic ...


The NtrY/NtrX two‐component system is involved in controlling nitrate assimilation in Herbaspirillum seropedicae strain SmR1

16-Sep-2016 | Paloma Bonato, Lysangela R. Alves, Juliana H. Osaki, Liu Un Rigo, Fabio O. Pedrosa, Emanuel M. Souza, Nan Zhang, Joe ..., FEBS Journal, 2016

Abstract Herbaspirillum seropedicae is a diazotrophic β‐Proteobacterium found endophytically associated with gramineae (Poaceae or graminaceous plants) such as rice, sorghum and sugar cane. In this work we show that nitrate‐dependent growth in this organism is regulated by the master nitrogen ...


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