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12,382 Newest Publications about the topic expression


Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity towards Rab8

01-Aug-2015 | Yuta Amagai; Takashi Itoh; Mitsunori Fukuda; Kensaku Mizuno, Journal of Biochemistry, 2015

Macroautophagy is a bulk degradation system conserved from yeast to human. In budding yeast, the guanine nucleotide-exchange factor (GEF) Sec2p is required for autophagy. We examined the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-GEF activity in autophagy in mammalian cells. ...


Albumin overload down-regulates integrin-{beta}1 through reactive oxygen species-endoplasmic reticulum stress pathway in podocytes

01-Aug-2015 | Yu-Chi Cheng; Chien-An Chen; Jer-Ming Chang; Hung-Chun Chen, Journal of Biochemistry, 2015

Proteinuria is a major hallmark of glomerular nephropathy and endoplasmic reticulum (ER) stress plays an important role in glomerular nephropathy. The protein levels of integrin-β1 in podocytes are found to be negative correlation with amount of proteinuria. This study investigated whether ...


Treatment with human IgG improves the early disease course in a mouse model of Duchenne muscular dystrophy

31-Jul-2015 | Jana Zschüntzsch, Yaxin Zhang, Florian Klinker, Gregor Makosch, Lars Klinge, Dörthe Malzahn, Heinrich Brinkmeier, Da ..., Journal of Neurochemistry, 2015

Abstract Duchenne muscular dystrophy (DMD) is a severe hereditary myopathy. Standard treatment by glucocorticosteroids is limited due to numerous side effects. The aim of this study was to test immunomodulation by immunoglobulin G (IgG) as treatment in the experimental mouse model (mdx) of ...


Fano‐like resonance and scattering in dielectric(core)–metal(shell) composites embedded in active host matrices

31-Jul-2015 | Leta Jule, Vadim Mal'nev, Belayneh Mesfin, Teshome Senbeta, Francis Dejene, Kittesa Rorro, physica status solidi (b), 2015

Abstract We investigate light scattering by core–shell consisting of metal/dielectric composites considering spherical and cylindrical nanoinclusions, within the framework of the conventional Rayleigh approximation. By writing the electric potential distribution of the dielectric core, metal ...


NaCl Influences Thermal Resistance and Cell Morphology of Escherichia coli Strains

28-Jul-2015 | Heeyoung Lee, Soomin Lee, Sejeong Kim, Jimyeong Ha, Jeeyeon Lee, Kyoung‐Hee Choi, Yohan Yoon, Journal of Food Safety, 2015

Abstract This study elucidated the effect of NaCl on the thermal resistance and cell morphology of Escherichia coli strains. E. coli O157:H7 NCCP11142, E. coli O111 ATCC12795 and E. coli O26 ATCC43887 were incubated in tryptic soy broth formulated with 0% NaCl (nonhabituated) as well as broth ...


Functional expression of sodium-glucose transporters in cancer [Medical Sciences]

28-Jul-2015 | Claudio Scafoglio; Bruce A. Hirayama; Vladimir Kepe; Jie Liu; Chiara Ghezzi; Nagichettiar Satyamurthy; Neda A. Moata ..., Proceedings of the National Academy of Sciences current issue, 2015

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in pancreatic ...


Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes

26-Jul-2015 | Author(s): Na Wang, Ziwei Wang, Xia Niu, Xiaoda Yang, Journal of Inorganic Biochemistry, 2015

Publication date: Available online 23 July 2015 Source:Journal of Inorganic Biochemistry Author(s): Na Wang, Ziwei Wang, Xia Niu, Xiaoda Yang In the present work, we synthesised three novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes (VOohpada,VOmhpada,VOphpada) ...


Elevated dopamine concentration in light‐adapted zebrafish retinas is correlated with increased dopamine synthesis and metabolism

25-Jul-2015 | VP Connaughton, BB Wetzell, LS Arneson, V DeLucia, AL Riley, Journal of Neurochemistry, 2015

Abstract Probing zebrafish (Danio rerio) retinal cryostat sections, collected either 8 hr into the light or dark cycle, with an antibody to tyrosine hydroxylase (TH) identified a single population of immunopositive cells in the inner retina. However, the observed labeling patterns were not ...


Corticotropin releasing factor up‐regulates the expression and function of norepinephrine transporter in SK‐N‐BE (2) M17 cells

25-Jul-2015 | Jingjing Huang, Turan Tufan, Maoxian Deng, Gary Wright, Meng‐Yang Zhu, Journal of Neurochemistry, 2015

Abstract Corticotropin releasing factor (CRF) has been implicated to act as a neurotransmitter or modulator in central nervous activation during stress. In the present study, we examined the regulatory effect of CRF on the expression and function of the norepinephrine transporter (NET) in ...


DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway

25-Jul-2015 | Carmen Rodríguez‐Seoane, Adriana Ramos, Carsten Korth, Jesús R. Requena, Journal of Neurochemistry, 2015

Abstract Disrupted in schizophrenia (DISC1) is a risk factor for chronic mental disease. In a previous proteomic study, we reported that knocking down DISC1 results in a sharp decrease in the levels of the neuropeptide precursor VGF (non‐acronymic) and leads to reduced activation of cAMP ...


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