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13,262 Newest Publications about the topic expression


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Regulation of collagen expression using nanoparticle mediated inhibition of TGF-[small beta] activation

25-Nov-2015 | BINBIN LI; Tristan Clemons; Vipul Agarwal; Jessica Kretzmann; Michael Bradshaw; Priyanka Toshniwal; Nicole M. Smith; ..., New Journal of Chemistry, 2015

PXS64 is a stable mannose-6-phosphate (M6P) analogue which has been shown to be an effective anti-fibrotic agent by inhibiting the activation of latent TGF-β1. However PXS64 is insoluble in physiological conditions. Herein, we report a multifunctional poly(glycidyl methacrylate) (PGMA) polymeric ...


Expression of concern: A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones

24-Nov-2015 | Richard Kelly, Organic & Biomolecular Chemistry, 2015

Expression of concern for ‘A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones’ by Adán B. González-Pérez et al., Org. Biomol. Chem., 2014, 12, 7694–7701.


Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells

22-Nov-2015 | M Sousa, V Machado, ME Figueira, B Sepodes, P Barata, L Ribeiro, R Soares, Journal of Cellular Biochemistry, 2015

Abstract Polyphenols are a class of natural compounds whose potential as antioxidant, anti‐inflammatory and anti‐angiogenesis has been reported in many pathological conditions. Red raspberry extract, rich in polyphenols, has been reported to exert anti‐inflammatory effects and prevent cell ...


Molecular Mechanisms Associated with Particulate and Soluble Heteroglycan Mediated Immune Response

22-Nov-2015 | K. Sanjana, P. Devi, Dhanesh Krishna, Joyjyoti Das, Tarun Agarwal, Kalpana Kumari, Somnath Maji, Sudip K. Ghosh, Tap ..., Journal of Cellular Biochemistry, 2015

ABSTRACT Immune responses are outcomes of complex molecular machinery which occur inside the cells. Unravelling the cellular mechanisms induced by immune stimulating molecules such as glycans and determining their structure‐function relationship are therefore important factors to be assessed. ...


Global metabolic profiling for the study of Rhizoma Paridis saponins‐induced hepatotoxicity in rats

21-Nov-2015 | Shuli Man, Peiyu Qiu, Jing Li, Liming Zhang, Wenyuan Gao, Environmental Toxicology, 2015

ABSTRACT Rhizoma Paridis saponins (RPS) is a traditional Chinese medicine (TCM) from the plant Paris polyphylla var. yunnanensis (Fr.) Hand.‐Mazz. Despite its potentially clinical utility such as anticancer and anti‐inflammation, it has slight side effects and toxicity as previous report. In ...


mTOR inhibition by rapamycin protects against deltamethrin‐induced apoptosis in PC12 Cells

21-Nov-2015 | Yun Sun Park, Jae Hyeon Park, Juyeon Ko, In Chul Shin, Hyun Chul Koh, Environmental Toxicology, 2015

ABSTRACT The autophagy pathway can be induced and upregulated in response to intracellular reactive oxygen species (ROS). In this study, we explored a novel pharmacotherapeutic approach involving the regulation of autophagy to prevent deltamethrin (DLM) neurotoxicity. We found that DLM‐induced ...


Cellular and molecular hypoxic response in common carp (Cyprinus carpio) exposed to linear alkylbenzene sulfonate at sublethal concentrations

21-Nov-2015 | Junichi Tasaki, Kei Nakayama, Ichiyo Shimizu, Hiroko Yamada, Takahiro Suzuki, Naohiro Nishiyama, Masayuki Yamane, Environmental Toxicology, 2015

Abstract Linear alkylbenzene sulfonate (LAS) is an anionic surfactant commonly used in cleaning agents such as laundry detergents. Trace amounts of LAS are released into environmental waters after processing in wastewater treatment plants after the use of this chemical. Acute toxicity of LAS ...


A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech

21-Nov-2015 | Kurdyumov, Alexey S; Manuvera, Valentin A; Baskova, Isolda P; Lazarev, Vassili N, BMC Biochemistry, 2015

Background: Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and antibacterial activity. This enzyme attracts interest because it expresses ...


DMSO Enhances TGF‐β Activity by Recruiting the Type II TGF‐β Receptor from Intracellular Vesicles to the Plasma Membrane

20-Nov-2015 | Shuan Shian Huang, Chun‐Lin Chen, Franklin W. Huang, Wei‐Hsien Hou, Jung San Huang, Journal of Cellular Biochemistry, 2015

Abstract DMSO is used to treat many diseases/symptoms. The molecular basis of the pharmacological actions of DMSO has been unclear. We hypothesized that DMSO exerts some of these actions by enhancing TGF‐β activity. Here we show that DMSO enhances TGF‐β activity by ∼3‐4‐fold in Mv1Lu and ...


Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice

20-Nov-2015 | A. N. A. Verty et al., PLoS ONE, 2015

by A. N. A. Verty, A. Stefanidis, A. J. McAinch, D. H. Hryciw, Brian Oldfield The cannabinoid receptor 2 (CB2) is well known for its immune modulatory role. However, recent localisation of CB2 receptors in metabolically active tissue suggests that the CB2 receptor plays a significant role in ...


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