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10,728 Newest Publications about the topic expression


Activation of NLRP3 and AIM2 Inflammasomes in Kupffer Cells in Hepatic Ischemia/Reperfusion

18-10-2014 | Hyo‐Yeon Kim, Seok‐Joo Kim, Sun‐Mee Lee, FEBS Journal, 2014

Abstract Inflammasome activation by danger signals in ischemia/reperfusion (I/R) injury is responsible for the sterile inflammatory response. Signals triggering formation and activation of the inflammasome involve the generation of oxidative stress. The aim of this study was to examine the ...


Kinetic characterization of the human O‐phosphoethanolamine phospho‐lyase reveals unconventional features of this specialized pyridoxal phosphate‐dependent lyase

18-10-2014 | Davide Schiroli, Luca Ronda, Alessio Peracchi, FEBS Journal, 2014

Abstract Human O‐phosphoethanolamine (PEA) phospho‐lyase is a pyridoxal 5’‐phosphate (PLP) dependent enzyme that catalyzes the degradation of PEA to acetaldehyde, phosphate and ammonia. Physiologically, the enzyme is involved in phospholipid metabolism and is found mainly in the brain, where ...


Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

18-10-2014 | Xiurong Zhao, Guanghua Sun, Shun‐Ming Ting, Shen Song, Jie Zhang, Nancy J Edwards, Jaroslaw Aronowski, Journal of Neurochemistry, 2014

Abstract As a consequence of intracerebral hemorrhage (ICH), blood components enter brain parenchyma causing progressive damage to the surrounding brain. Unless hematoma is cleared, the reservoirs of blood continue to inflict injury to neurovascular structures and blunt the brain repair ...


Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells

18-10-2014 | Aude Jacob, Sophie Potin, Bruno Saubaméa, Dominique Crete, Jean‐Michel Scherrmann, Emmanuel Curis, Carole Peyssonnau ..., Journal of Neurochemistry, 2014

Abstract The expression of aryl hydrocarbon receptor (AhR) transcription factor was detected at transcript level in freshly isolated human brain microvessels and in the hCMEC/D3 human cerebral microvascular endothelial cell line. Recent studies have demonstrated that AhR pathway is able to ...


Development of fibrin conjugated chitosan/nano β‐TCP composite scaffolds with improved cell supportive property for bone tissue regeneration

18-10-2014 | Nadeem Siddiqui, Krishna Pramanik, Journal of Applied Polymer Science, 2014

ABSTRACT In the present study, an attempt has been made to improve cell supportive property of chitosan/nano beta tri‐calcium phosphate (β‐TCP) composite scaffolds by modification of scaffold surface with fibrin using ethyl‐3‐(3‐dimethylaminopropyl) carbodimide (EDC) as crosslinking agent. The ...


Lightweight object oriented structure analysis: Tools for building tools to analyze molecular dynamics simulations

18-10-2014 | Tod D. Romo, Nicholas Leioatts, Alan Grossfield, Journal of Computational Chemistry, 2014

LOOS (Lightweight Object Oriented Structure‐analysis) is a C++ library designed to facilitate making novel tools for analyzing molecular dynamics simulations by abstracting out the repetitive tasks, allowing developers to focus on the scientifically relevant part of the problem. LOOS supports ...


Interaction Energy of Large Molecules from Restrained Denominator MP2-F12

17-10-2014 | Yu-ya Ohnishi; Kazuya Ishimura; Seiichiro Ten-no, Journal of Chemical Theory and Computation, 2014

A new one-parameter correction scheme to second-order Møller–Plesset many-body perturbation theory (MP2) has been proposed to correctly evaluate intermolecular interaction energies of large π–π dispersion interaction systems as well as hydrogen-bonded and σ–σ dispersion interaction ones. The ...


Correlation of Apical Fluid-Regulating Channel Proteins with Lung Function in Human COPD Lungs

17-10-2014 | Runzhen Zhao et al., PLoS ONE, 2014

by Runzhen Zhao, Xinrong Liang, Meimi Zhao, Shan-Lu Liu, Yao Huang, Steven Idell, Xiumin Li, Hong-Long Ji Links between epithelial ion channels and chronic obstructive pulmonary diseases (COPD) are emerging through animal model and in vitro studies. However, clinical correlations between ...


Expression Profiling of FLOWERING LOCUS T-Like Gene in Alternate Bearing ‘Hass' Avocado Trees Suggests a Role for PaFT in Avocado Flower Induction

17-10-2014 | Dafna Ziv et al., PLoS ONE, 2014

by Dafna Ziv, Tali Zviran, Oshrat Zezak, Alon Samach, Vered Irihimovitch In many perennials, heavy fruit load on a shoot decreases the ability of the plant to undergo floral induction in the following spring, resulting in a pattern of crop production known as alternate bearing. Here, we studied ...


Effects of miR-33a-5P on ABCA1/G1-Mediated Cholesterol Efflux under Inflammatory Stress in THP-1 Macrophages

17-10-2014 | Min Mao et al., PLoS ONE, 2014

by Min Mao, Han Lei, Qing Liu, Yaxi Chen, Lei Zhao, Qing Li, Suxin Luo, Zhong Zuo, Quan He, Wei Huang, Nan Zhang, Chao Zhou, Xiong Z. Ruan The present study is to investigate whether inflammatory cytokines inhibit ABCA1/ABCG1-mediated cholesterol efflux by regulating miR-33a-5P in THP-1 ...


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