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16,229 Newest Publications about the topic expression

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Thiazolidine: A Potent Candidate for Central Nervous System Diseases

21-Feb-2017 | S. Bahare, Radhe; Ganguly, Swastika; Agrawal, Ritesh; N. Dikshit, Subodh, Central Nervous System Agents in Medicinal Chemistry, 2017

Abstract: Thiazolidines are multifaceted molecules and exhibit various kinds of biological activities including anticonvulsant and antidepressant activities, chemically thiazolidinediones is a diversified class of heterocyclic nucleus. Thiazolidinediones have shown significant biological ...

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Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics

19-Feb-2017 | Author(s): Mohammed M.A. Hawash, Deniz Cansen Kahraman, Fikriye Eren, Rengul Cetin Atalay, Sultan Nacak Baytas, European Journal of Medicinal Chemistry, 2017

Publication date: 31 March 2017 Source:European Journal of Medicinal Chemistry, Volume 129 Author(s): Mohammed M.A. Hawash, Deniz Cansen Kahraman, Fikriye Eren, Rengul Cetin Atalay, Sultan Nacak Baytas Despite having the second highest mortality associated with cancer, currently ...

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Novel multi-substituted benzyl acridone derivatives as survivin inhibitors for hepatocellular carcinoma treatment

19-Feb-2017 | Author(s): Bin Zhang, Ning Wang, Cunlong Zhang, Chunmei Gao, Wei Zhang, Kang Chen, Weibin Wu, Yuzong ..., European Journal of Medicinal Chemistry, 2017

Publication date: Available online 17 February 2017 Source:European Journal of Medicinal Chemistry Author(s): Bin Zhang, Ning Wang, Cunlong Zhang, Chunmei Gao, Wei Zhang, Kang Chen, Weibin Wu, Yuzong Chen, Chunyan Tan, Feng Liu, Yuyang Jiang Sorafenib was the only ...

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IJMS, Vol. 18, Pages 447: Biomarkers in Pediatric Community-Acquired Pneumonia

19-Feb-2017 | Principi, Nicola ; Esposito, Susanna, International Journal of Molecular Sciences, 2017

Community-acquired pneumonia (CAP) is an infectious disease caused by bacteria, viruses, or a combination of these infectious agents. The severity of the clinical manifestations of CAP varies significantly. Consequently, both the differentiation of viral from bacterial CAP cases and the accurate ...

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Angiopoietin‐2 Enhances Osteogenic Differentiation of Bone Marrow Stem Cells

18-Feb-2017 | Mi‐Lan Kang, Eun‐Ah Kim, Se‐Young Jeong, Gun‐Il Im, Journal of Cellular Biochemistry, 2017

ABSTRACT Our previous studies revealed that co‐transplantation of bone marrow stem cells (BMSCs) and adipose‐derived stem cells (ADSCs) can enhance bone regeneration and angiogenesis. However, it is unclear which genes are involved in the regulation of osteogenesis and/or angiogenesis during ...

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Neferine Potentiates the Antitumor Effect of Cisplatin in Human Lung Adenocarcinoma Cells via a Mitochondria‐mediated Apoptosis Pathway

18-Feb-2017 | Kalai Selvi Sivalingam, Poornima Paramasivan, Ching Feng Weng, Viswanadha Vijaya Padma, Journal of Cellular Biochemistry, 2017

Abstract Cisplatin is one of the most potent chemotherapeutic agents for the treatment of many types of solid tumors but its efficacy is often limited by the development of resistance and dose limiting toxicity. Neferine is an alkaloid isolated from seed embryo of Nelumbo nucifera, it has ...

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The Role of c‐SKI in Regulation of TGFβ‐induced Human Cardiac Fibroblast Proliferation and ECM Protein Expression

18-Feb-2017 | Juan Wang, Liping Guo, Difei Shen, Xiao Xu, Jiaping Wang, Suxia Han, Wen He, Journal of Cellular Biochemistry, 2017

Abstract Cardiac fibrosis is characterized by over‐deposition of extracellular matrix (ECM) proteins and over‐proliferation of cardiac fibroblast, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. Transforming growth factor β 1 (TGFβ1) is ...

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IJMS, Vol. 18, Pages 443: FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?

18-Feb-2017 | Russo, Daniela ; Merolla, Francesco ; Mascolo, Massimo ; Ilardi, Gennaro ; Romano, Simona ; Varricchio, Silvia ; Nap ..., International Journal of Molecular Sciences, 2017

Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better ...

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First Synthesis of an Oridonin‐Conjugated Iridium(III) Complex for the Intracellular Tracking of NF‐κB in Living Cells

17-Feb-2017 | Wanhe Wang, Chao Yang, Sheng Lin, Kasipandi Vellaisamy, Guodong Li, Weihong Tan, Chung-Hang Leung, Dik-Lung Ma, Chemistry - A European Journal, 2017

NF‐κB is a critical transcription factor that plays an important role in mediating inflammation, the immune response, and cell proliferation. The activation of NF‐κB leads to an enhancement of proinflammatory mediator expression, which is implicated in the pathogenesis of a variety of diseases. ...

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Depressive disorder and gastrointestinal dysfunction after myocardial infarct are associated with abnormal tryptophan-5-hydroxytryptamine metabolism in rats

17-Feb-2017 | Xiaofang Lu; Yuefen Wang; Chunyan Liu; Yangang Wang, PLoS ONE, 2017

by Xiaofang Lu, Yuefen Wang, Chunyan Liu, Yangang Wang In this study, we investigated the relationship between tryptophan-5-hydroxytryptamine metabolism, depressive disorder, and gastrointestinal dysfunction in rats after myocardial infarction. Our goal was to elucidate the physiopathologic ...

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