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10,772 Newest Publications about the topic expression


Hesperetin Inhibit Adipocyte Differentiation and Enhance Bax‐ and p21‐Mediated Adipolysis in Human Mesenchymal Stem Cell Adipogenesis

26-10-2014 | Pandurangan Subash‐Babu,, Ali A Alshatwi, Journal of Biochemical and Molecular Toxicology, 2014

ABSTRACT We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)–induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 13.2 μmol for 24 h and 89.4 ± 11.4 μmol in 48 h, whereas in preadipocytes was 87.6 ± ...


IJMS, Vol. 15, Pages 19394-19405: Catalpol Suppresses Proliferation and Facilitates Apoptosis of OVCAR-3 Ovarian Cancer Cells through Upregulating MicroRNA-200 and Downregulating MMP-2 Expression

24-10-2014 | Gao, Na ; Tian, Jian-Xin ; Shang, Yu-Hong ; Zhao, Dan-Yi ; Wu, Tao, International Journal of Molecular Sciences, 2014

Catalpol is expected to possess diverse pharmacological actions including anti-cancer, anti-inflammatory and hypoglycemic properties. Matrix metalloproteinase-2 (MMP-2) is closely related to the pathogenesis of ovarian cancer. In addition, microRNA-200 (miR-200) can modulate phenotype, ...


FoxA4 Favours Notochord Formation by Inhibiting Contiguous Mesodermal Fates and Restricts Anterior Neural Development in Xenopus Embryos

24-10-2014 | Sabrina Murgan et al., PLoS ONE, 2014

by Sabrina Murgan, Aitana Manuela Castro Colabianchi, Renato José Monti, Laura Elena Boyadjián López, Cecilia E. Aguirre, Ernesto González Stivala, Andrés E. Carrasco, Silvia L. López In vertebrates, the embryonic dorsal midline is a crucial signalling centre that patterns the surrounding ...


Pro-Inflammatory and Pro-Oxidant Status of Pancreatic Islet In Vitro Is Controlled by TLR-4 and HO-1 Pathways

24-10-2014 | Kevin Vivot et al., PLoS ONE, 2014

by Kevin Vivot, Allan Langlois, William Bietiger, Stéphanie Dal, Elodie Seyfritz, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Jean-Pierre Gies, Séverine Sigrist Since their isolation until implantation, pancreatic islets suffer a major stress leading to the activation of inflammatory ...


Molecules, Vol. 19, Pages 17141-17153: Riboflavin Accumulation and Molecular Characterization of cDNAs Encoding Bifunctional GTP Cyclohydrolase II/3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase, Lumazine Synthase, and Riboflavin Synthase in Different Organs of Lycium chinense Plant

24-10-2014 | Tuan, Pham Anh; Zhao, Shicheng ; Kim, Jae Kwang; Kim, Yeon Bok; Yang, Jingli ; Li, Cheng Hao; Kim, Sun-Ju ; Arasu, M ..., Molecules, 2014

Riboflavin (vitamin B2) is the precursor of flavin mononucleotide and flavin adenine dinucleotide—essential cofactors for a wide variety of enzymes involving in numerous metabolic processes. In this study, a partial-length cDNA encoding bifunctional GTP cyclohydrolase ...


Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

24-10-2014 | Maimaiti Yisireyili et al., PLoS ONE, 2014

by Maimaiti Yisireyili, Shinichi Saito, Shaniya Abudureyimu, Yelixiati Adelibieke, Hwee-Yeong Ng, Fuyuhiko Nishijima, Kyosuke Takeshita, Toyoaki Murohara, Toshimitsu Niwa Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). (Pro)renin receptor ...


Molecules, Vol. 19, Pages 17173-17186: 2-(1H-Benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol, a Benzimidazole Derivative, Inhibits T Cell Proliferation Involving H+/K+-ATPase Inhibition

24-10-2014 | Liu, Jin ; Huang, Ning ; Li, Ning ; Liu, Si-Nian ; Li, Min-Hui ; Li, Hua ; Luo, Xing-Yan ; Wang, Yan-Tang ; Li, Li-M ..., Molecules, 2014

In this study, a benzimidazole derivative named BMT-1 is revealed as a potential immunomodulatory agent. BMT-1 inhibits the activity of H+/K+-ATPases from anti-CD3/CD28 activated T cells. Furthermore, inhibition the H+/K+-ATPases by use of BMT-1 should lead to intracellular acidification, ...


Plant Oxidosqualene Metabolism: Cycloartenol Synthase–Dependent Sterol Biosynthesis in Nicotiana benthamiana

24-10-2014 | Elisabet Gas-Pascual et al., PLoS ONE, 2014

by Elisabet Gas-Pascual, Anne Berna, Thomas J. Bach, Hubert Schaller The plant sterol pathway exhibits a major biosynthetic difference as compared with that of metazoans. The committed sterol precursor is the pentacyclic cycloartenol (9β,19-cyclolanost-24-en-3β-ol) and not lanosterol ...


IJMS, Vol. 15, Pages 19355-19368: Emodin Ameliorates LPS-Induced Acute Lung Injury, Involving the Inactivation of NF-κB in Mice

24-10-2014 | Xiao, Min ; Zhu, Tao ; Zhang, Wei ; Wang, Tao ; Shen, Yong-Chun ; Wan, Qiong-Fang ; Wen, Fu-Qiang, International Journal of Molecular Sciences, 2014

Acute lung injury (ALI) and its severe manifestation of acute respiratory distress syndrome (ARDS) are well-known illnesses. Uncontrolled and self-amplified pulmonary inflammation lies at the center of the pathology of this disease. Emodin, the bio-active coxund of herb Radix rhizoma Rhei, shows ...


Application of Adenosine Triphosphate Affinity Probe and Scheduled Multiple-Reaction Monitoring Analysis for Profiling Global Kinome in Human Cells in Response to Arsenite Treatment

23-10-2014 | Lei Guo; Yongsheng Xiao; Yinsheng Wang, Analytical Chemistry, 2014

Phosphorylation of cellular components catalyzed by kinases plays important roles in cell signaling and proliferation. Quantitative assessment of perturbation in global kinome may provide crucial knowledge for elucidating the mechanisms underlying the cytotoxic effects of environmental toxicants. ...


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