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Variation of ascorbic acid concentration in fruits of cultivated and wild apples

15-Jan-2017 | Author(s): Ting Fang, Qiaoling Zhen, Liao Liao, Albert Owiti, Li Zhao, Schuyler S. Korban, Yuepeng Han, Food Chemistry, 2017

Publication date: 15 June 2017 Source:Food Chemistry, Volume 225 Author(s): Ting Fang, Qiaoling Zhen, Liao Liao, Albert Owiti, Li Zhao, Schuyler S. Korban, Yuepeng Han Ascorbic acid (AsA) content in mature fruits of 457 apple accessions were measured, and a great variation in ...


Molecules, Vol. 22, Pages 129: Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression

14-Jan-2017 | Dludla, Phiwayinkosi V.; Muller, Christo J. F.; Joubert, Elizabeth ; Louw, Johan ; Essop, M. Faadiel; Gabuza, Kwazi ..., Molecules, 2017

Aspalathin (ASP) can protect H9c2 cardiomyocytes against high glucose (HG)-induced shifts in myocardial substrate preference, oxidative stress, and apoptosis. The protective mechanism of ASP remains unknown. However, as one of possible, it is well known that phytochemical flavonoids reduce ...


IJMS, Vol. 18, Pages 163: Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2—Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors

14-Jan-2017 | Chang, Fung-Wei ; Fan, Hueng-Chuen ; Liu, Jui-Ming ; Fan, Tai-Ping ; Jing, Jin ; Yang, Chia-Ling ; Hsu, Ren-Jun, International Journal of Molecular Sciences, 2017

Background: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding the molecular mechanisms of drug resistance is important for the ...


IJMS, Vol. 18, Pages 156: Ftr82 Is Critical for Vascular Patterning during Zebrafish Development

13-Jan-2017 | Chang, Hsueh-Wei ; Wang, Wen-Der ; Chiu, Chien-Chih ; Chen, Chiou-Hua ; Wang, Yi-Shan ; Chen, Zih-Ying ; Liu, Wangta ..., International Journal of Molecular Sciences, 2017

Cellular components and signaling pathways are required for the proper growth of blood vessels. Here, we report for the first time that a teleost-specific gene ftr82 (finTRIM family, member 82) plays a critical role in vasculature during zebrafish development. To date, there has been no ...


Testicular Dysgenesis Syndrome and Long-Lasting Epigenetic Silencing of Mouse Sperm Genes Involved in the Reproductive System after Prenatal Exposure to DEHP

13-Jan-2017 | Ludwig Stenz; Jessica Escoffier; Rita Rahban; Serge Nef; Ariane Paoloni-Giacobino, PLoS ONE, 2017

by Ludwig Stenz, Jessica Escoffier, Rita Rahban, Serge Nef, Ariane Paoloni-Giacobino The endocrine disruptor bis(2-ethylhexyl) phthalate (DEHP) has been shown to exert adverse effects on the male animal reproductive system. However, its mode of action is unclear and a systematic analysis of its ...


IJMS, Vol. 18, Pages 110: Reactive Oxygen Species Generated by NADPH Oxidases Promote Radicle Protrusion and Root Elongation during Rice Seed Germination

13-Jan-2017 | Li, Wen-Yan ; Chen, Bing-Xian ; Chen, Zhong-Jian ; Gao, Yin-Tao ; Chen, Zhuang ; Liu, Jun, International Journal of Molecular Sciences, 2017

Seed germination is a complicated biological process that requires regulation through various enzymatic and non-enzymatic mechanisms. Although it has been recognized that reactive oxygen species (ROS) regulate radicle emergence and root elongation in a non-enzymatic manner during dicot seed ...


A Global User-Driven Model for Tile Prefetching in Web Geographical Information Systems

13-Jan-2017 | Shaoming Pan; Yanwen Chong; Hang Zhang; Xicheng Tan, PLoS ONE, 2017

by Shaoming Pan, Yanwen Chong, Hang Zhang, Xicheng Tan A web geographical information system is a typical service-intensive application. Tile prefetching and cache replacement can improve cache hit ratios by proactively fetching tiles from storage and replacing the appropriate tiles from the ...


OCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In Vivo

13-Jan-2017 | Hye Jung Ihn; Taeho Lee; Ju Ang Kim; Doohyun Lee; Nam Doo Kim; Hong-In Shin; Yong Chul Bae; Eui Kyun Park, PLoS ONE, 2017

by Hye Jung Ihn, Taeho Lee, Ju Ang Kim, Doohyun Lee, Nam Doo Kim, Hong-In Shin, Yong Chul Bae, Eui Kyun Park An abnormal increase in osteoclast differentiation and activation results in various bone-resorptive diseases, including periodontitis, rheumatoid arthritis, and osteoporosis. Chemical ...


E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy

13-Jan-2017 | Jennifer L. Major; Aaraf Dewan; Maysoon Salih; John J. Leddy; Balwant S. Tuana, PLoS ONE, 2017

by Jennifer L. Major, Aaraf Dewan, Maysoon Salih, John J. Leddy, Balwant S. Tuana Rationale The E2F pathway plays a critical role in cardiac growth and development, yet its role in cardiac metabolism remains to be defined. Metabolic changes play important roles in human heart failure and ...


A Split-GFP Gateway Cloning System for Topology Analyses of Membrane Proteins in Plants

13-Jan-2017 | Wenjun Xie; Mads Eggert Nielsen; Carsten Pedersen; Hans Thordal-Christensen, PLoS ONE, 2017

by Wenjun Xie, Mads Eggert Nielsen, Carsten Pedersen, Hans Thordal-Christensen To understand the function of membrane proteins, it is imperative to know their topology. For such studies, a split green fluorescent protein (GFP) method is useful. GFP is barrel-shaped, consisting of 11 β-sheets. ...


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