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10,474 Newest Publications about the topic expression

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The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling

01-10-2013 | Chandor-Proust A; Bibby J; Regent-Kloeckner M; Roux J; Guittard-Crilat E; Poupardin R; Riaz MA; Paine M; Dauphin-Vil ..., Biochemical Journal, 2013

The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of ...

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Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

01-10-2013 | Aregger M; Cowling VH, Biochemical Journal, 2013

Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II) transcripts, which occurs ...

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EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

01-10-2013 | Sjogren J; Struwe WB; Cosgrave EFJ; Rudd PM; Stervander M; Allhorn M; Hollands A; Nizet V; Collin M, Biochemical Journal, 2013

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, ...

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The Role of p38 MAPK in Neutrophil Functions: Single Cell Chemotaxis and Surface Marker Expression

18-09-2013 | Donghyuk Kim; Christy Haynes, Analyst, 2013

Neutrophils act as the first line of defence in the human immune system by migrating to the site of abnormal events and performing their designated roles. One major signalling pathway that drives neutrophil action in vivo is the p38 mitogen-activated protein kinase (MAPK)-dependent pathway. ...

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Molecular Dynamics Studies of the size and temperature dependence of the Kinetics of Freezing of Fe Nanoparticles

16-09-2013 | Author(s): Bo Zhao , Jinfan Huang , Lawrence S. Bartell, Journal of Solid State Chemistry, 2013

Publication date: Available online 15 September 2013 Source:Journal of Solid State Chemistry Author(s): Bo Zhao , Jinfan Huang , Lawrence S. Bartell Molecular dynamics (MD) computer simulations have been carried out and a novel modified technique of Voronoi polyhedra has been performed ...

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AMP-activated protein kinase mediates insulin-like and lipo-mobilising effects of β-glucan-rich polysaccharides isolated from Pleurotus sajor-caju (Fr.), Singer mushroom, in 3T3-L1 cells

16-09-2013 | Author(s): G. Kanagasabapathy , K.H. Chua , S.N.A. Malek , S. Vikineswary , U.R. Kuppusamy, Food Chemistry, 2013

Publication date: 15 February 2014 Source:Food Chemistry, Volume 145 Author(s): G. Kanagasabapathy , K.H. Chua , S.N.A. Malek , S. Vikineswary , U.R. Kuppusamy Mushrooms have been used to treat various diseases for thousands of years. In the present study, the effects of Pleurotus ...

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GPR56 promotes myoblast fusion through SRE‐ and NFAT‐mediated signaling but is not essential for muscle development in vivo

14-09-2013 | Melissa P. Wu, Jamie R. Doyle, Brenda Barry, Ariane Beauvais, Anete Rozkalne, Xianhua Piao, Michael W. Lawlor, Alan ..., FEBS Journal, 2013

Abstract Mammalian muscle cell differentiation is a complex process of multiple steps for which many of the factors involved have not yet been defined. In a screen to identify the regulators of myogenic cell fusion, we found that the G‐protein coupled receptor 56 (GPR56) gene was transiently ...

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Pharmacokinetics of Oral Dichloroacetate in Dogs

13-09-2013 | Herbert W. Maisenbacher, Albert L. Shroads, Guo Zhong, Adam D. Daigle, Monica M. Abdelmalak, Ivan Sosa Samper, Brand ..., Journal of Biochemical and Molecular Toxicology, 2013

ABSTRACT We characterized the pharmacokinetics and dynamics of dichloroacetate (DCA), an investigational drug for mitochondrial diseases, pulmonary arterial hypertension, and cancer. Adult Beagle dogs were orally administered 6.25 mg/kg q12h DCA for 4 weeks. Plasma kinetics was determined ...

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The oxygen‐tolerant and NAD‐dependent formate dehydrogenase from Rhodobacter capsulatus is able to catalyze the reduction of CO2 to formate

13-09-2013 | Tobias Hartmann, Silke Leimkühler, FEBS Journal, 2013

Abstract The formate dehydrogenase from Rhodobacter capsulatus (RcFDH) is an oxygen‐tolerant protein with a (αβγ)2 subunit composition that is localized in the cytoplasm. It belongs to the group of metal and NAD+‐dependent FDHs with the coordination of a molybdenum cofactor (Moco), 4x[Fe4S4] ...

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X‐ray Structural Analysis of Tau‐Tubulin Kinase 1 and Its Interactions with Small Molecular Inhibitors

13-09-2013 | Yafeng Xue, Paul T. Wan, Per Hillertz, Fritz Schweikart, Yanlong Zhao, Lisa Wissler, Niek Dekker, ChemMedChem, 2013

Abstract Tau‐tubulin kinase 1 (TTBK1) is a serine/threonine/tyrosine kinase that putatively phosphorylates residues including S422 in tau protein. Hyperphosphorylation of tau protein is the primary cause of tau pathology and neuronal death associated with Alzheimer’s disease. A library of 12 ...

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