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Inhibition of P-Glycoprotein Mediated Efflux of Paclitaxel by Coumarin Derivatives in Cancer Stem Cells: An In Silico Approach

23-Jul-2016 | Tripathi, Anushree; Misra, Krishna, Combinatorial Chemistry, 2016

Abstract: P-glycoprotein (P-gp) is well known to cause multidrug resistance (MDR) in cancer cells. This MDR leads to cancer recurrence which is a major obstacle in cancer treatment. High P-gp expression has been observed in the population of cancer stem cells (CSCs) having self-renewal ...


IJMS, Vol. 17, Pages 1145: Expression and Distribution Pattern of Aquaporin 4, 5 and 11 in Retinas of 15 Different Species

16-Jul-2016 | Amann, Barbara ; Kleinwort, Kristina J. H.; Hirmer, Sieglinde ; Sekundo, Walter ; Kremmer, Elisabeth ; Hauck, Stefan ..., International Journal of Molecular Sciences, 2016

Aquaporins (AQPs) are small integral membrane proteins with 13 members in mammals and are essential for water transport across membranes. They are found in many different tissues and cells. Currently, there are conflicting results regarding retinal aquaporin expression and subcellular ...


SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments through an Increment in ROS Production

15-Jul-2016 | Margalida Torrens‐Mas, Daniel Gabriel Pons, Jorge Sastre‐Serra, Jordi Oliver, Pilar Roca, Journal of Cellular Biochemistry, 2016

Abstract SIRT3, the major deacetylase in mitochondria, plays a crucial role modulating ROS production and scavenging by regulating key proteins implicated in mitochondrial turnover and in antioxidant defenses. Therefore, SIRT3 could confer resistance to chemotherapy‐induced oxidative stress, ...


IJMS, Vol. 17, Pages 1123: Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells

15-Jul-2016 | Karabay, Arzu Zeynep; Koc, Asli ; Ozkan, Tulin ; Hekmatshoar, Yalda ; Sunguroglu, Asuman ; Aktan, Fugen ; Buyukbingo ..., International Journal of Molecular Sciences, 2016

Methylsulfonylmethane (MSM) is an organic sulfur-containing compound which has been used as a dietary supplement for osteoarthritis. MSM has been shown to reduce oxidative stress and inflammation, as well as exhibit apoptotic or anti-apoptotic effects depending on the cell type or activating ...


IJMS, Vol. 17, Pages 1138: Genome-Wide Analysis of Codon Usage Bias in Epichloë festucae

15-Jul-2016 | Li, Xiuzhang ; Song, Hui ; Kuang, Yu ; Chen, Shuihong ; Tian, Pei ; Li, Chunjie ; Nan, Zhibiao, International Journal of Molecular Sciences, 2016

Analysis of codon usage data has both practical and theoretical applications in understanding the basics of molecular biology. Differences in codon usage patterns among genes reflect variations in local base compositional biases and the intensity of natural selection. Recently, there have been ...


[Report] Chromatin remodeling inactivates activity genes and regulates neural coding

15-Jul-2016 | Yue Yang; Tomoko Yamada; Kelly K. Hill; Martin Hemberg; Naveen C. Reddy; Ha Y. Cho; Arden N. Guthrie; Anna Oldenborg ..., Science , 2016

Activity-dependent transcription influences neuronal connectivity, but the roles and mechanisms of inactivation of activity-dependent genes have remained poorly understood. Genome-wide analyses in the mouse cerebellum revealed that the nucleosome remodeling and deacetylase (NuRD) complex deposits ...


Bovine Viral Diarrhea Virus Type 2 Impairs Macrophage Responsiveness to Toll-Like Receptor Ligation with the Exception of Toll-Like Receptor 7

15-Jul-2016 | Robert G. Schaut; Julia F. Ridpath; Randy E. Sacco, PLoS ONE, 2016

by Robert G. Schaut, Julia F. Ridpath, Randy E. Sacco Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family. BVDV isolates are classified into two biotypes based on the development of cytopathic (cp) or non-cytopathic (ncp) effects in epithelial cell culture. BVDV isolates ...


IJMS, Vol. 17, Pages 1070: Involvement of the Interleukin-23/Interleukin-17 Axis in Chronic Hepatitis C Virus Infection and Its Treatment Responses

15-Jul-2016 | Meng, Ping ; Zhao, Suxian ; Niu, Xuemin ; Fu, Na ; Su, Shanshan ; Wang, Rongqi ; Zhang, Yuguo ; Qiao, Liang ; Nan, Y ..., International Journal of Molecular Sciences, 2016

Interleukin-23 (IL-23) and its downstream factor IL-17 are the key cytokines involved in immune and inflammatory response in chronic liver diseases. This study aimed to investigate the role and molecular mechanisms of the IL-23/Th17 axis in chronic hepatitis C virus (HCV) infection, and the ...


Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

15-Jul-2016 | Henrik H. Hansen; Katrine Fabricius; Pernille Barkholt; Pernille Kongsbak-Wismann; Chantal Schlumberger; Jacob Jelsi ..., PLoS ONE, 2016

by Henrik H. Hansen, Katrine Fabricius, Pernille Barkholt, Pernille Kongsbak-Wismann, Chantal Schlumberger, Jacob Jelsing, Dick Terwel, Annelies Termont, Charles Pyke, Lotte Bjerre Knudsen, Niels Vrang One of the major histopathological hallmarks of Alzheimer’s disease (AD) is cerebral deposits ...


Research Highlights

14-Jul-2016 | FEBS Journal, 2016

In this issue, we highlight work from Richard Kibbey, Gerald Shulman and colleagues showing that the ornithine cycle enzyme argininosuccinate synthetase regulates hepatic metabolism; a report from Pascale Cossart, Fabrizia Stavru and colleagues uncovering a role for septins in mitochondrial ...


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