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506,208 Newest Publications about the topic gc systems


Metformin and respiratory chain complex I: the last piece of the puzzle?

01-11-2014 | Fontaine E, Biochemical Journal, 2014

Metformin is the most widely prescribed drug used to treat patients affected by Type2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to complex I ...


NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...


Dual-view plane illumination microscopy for rapid and spatially isotropic imaging

01-11-2014 | Abhishek Kumar; Yicong Wu; Ryan Christensen; Panagiotis Chandris; William Gandler; Evan McCreedy; Alexandra Bokinsky ..., Nature Protocols, 2014

Nature Protocols 9, 2555 (2014). doi:10.1038/nprot.2014.172 Authors: Abhishek Kumar, Yicong Wu, Ryan Christensen, Panagiotis Chandris, William Gandler, Evan McCreedy, Alexandra Bokinsky, Daniel A Colón-Ramos, Zhirong Bao, Matthew McAuliffe, Gary Rondeau & Hari Shroff We ...


Evaluation of the Role of G Protein-Coupled Receptor Kinase 3 in Desensitization of Mouse Odorant Receptors in a Mammalian Cell Line and in Olfactory Sensory Neurons

01-11-2014 | Aya Kato; Johannes Reisert; Sayoko Ihara; Keiichi Yoshikawa; Kazushige Touhara, Chemical Senses, 2014

Thousands of odors are sensed and discriminated by G protein-coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs). G protein-coupled receptor kinases (GRKs) may have a role in desensitization of ORs. However, whether ORs are susceptible to agonist-dependent ...


Evidence that Humans Can Taste Glucose Polymers

01-11-2014 | Trina J. Lapis; Michael H. Penner; Juyun Lim, Chemical Senses, 2014

The sense of taste is essential for identifying potential nutrients and poisons. Accordingly, specialized taste receptor cells are activated by food-derived chemicals. Because of its importance in the human diet, oral detection of starch, or its degradation products, would presumably be highly ...


Using Sniffing Behavior to Differentiate True Negative from False Negative Responses in Trained Scent-Detection Dogs

01-11-2014 | Astrid Concha; Daniel S. Mills; Alexandre Feugier; Helen Zulch; Claire Guest; Rob Harris; Thomas W. Pike, Chemical Senses, 2014

False negatives are recorded in every chemical detection system, but when animals are used as a scent detector, some false negatives can arise as a result of a failure in the link between detection and the trained alert response, or a failure of the handler to identify the positive alert. A false ...


Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

21-10-2014 | Lionta, Evanthia; Spyrou, George; K. Vassilatis, Demetrios; Cournia, Zoe, Current Topics in Medicinal Chemistry, 2014

Abstract: Structure-based drug discovery (SBDD) is becoming an essential tool in assisting fast and cost-efficient lead discovery and optimization. The application of rational, structure-based drug design is proven to be more efficient than the traditional way of drug discovery since it aims to ...


Site-Specific Growth of Polymer on Silica Rods

21-10-2014 | Bo Peng; Giuseppe Soligno; Marlous Kamp; Bart van Nijs; Joost de Graaf; Marjolein Dijkstra; Rene van Roij; Alfons va ..., Soft Matter, 2014

Colloids specifically developed for self-assembly (SA) into advanced functional materials have rapidly become more complex, as this complexity allows for more ways to optimize both the SA process and the properties of the resulting materials. For instance, by creating ‘patchy’ particles more open ...


Highly selective transfer hydrogenation of functionalised nitroarenes using cobalt-based nanocatalysts

21-10-2014 | Rajenahally V. Jagadeesh; Debasis Banerjee; Percia Beatrice Arockiam; Henrik Junge; Kathrin Junge; Marga-Martina Poh ..., Green Chemistry, 2014

Anilines are important feedstock for the synthesis of a variety of chemicals such as dyes, pigments, pharmaceuticals and agrochemicals. The chemoselective catalytic reduction of nitro compounds represents the most important and prevalent process for the manufacture of functionalized anilines. ...


Complex magnetic fields breathe life into fluids

21-10-2014 | Kyle J. Solis; James E. Martin, Soft Matter, 2014

The vast majority of materials research exploits equilibrium or quasi-equilibrium processes to produce inert materials. In contrast, living systems depend on far-from-equilibrium kinetic processes that require a continuous flux of energy to persist and perform useful tasks. The Greek god ...


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