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975 Newest Publications about the topic medicinal chemistry
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Sustainable Practices in Medicinal Chemistry: Current State and Future Directions
09-05-2013 | Marian C. Bryan; Barry Dillon; Lawrence G. Hamann; Gregory J. Hughes; Michael E. Kopach; Emily A. Peterson; Mehrnaz ..., Journal of Medicinal Chemistry, 2013
Journal of Medicinal Chemistry DOI: 10.1021/jm400250p
Correction to Systematic in Vivo Screening of a Series of 1-Propyl-4-arylpiperidines against Dopaminergic and Serotonergic Properties in Rat Brain: A Scaffold-Jumping Approach
08-05-2013 | Cecilia Mattsson; Theresa Andreasson; Nicholas Waters; Clas Sonesson, Journal of Medicinal Chemistry, 2013
Journal of Medicinal Chemistry DOI: 10.1021/jm400509x
Artificial Neural Networks for Efficient Clustering of Conformational Ensembles and their Potential for Medicinal Chemistry
08-05-2013 | Pandini, Alessandro; Fraccalvieri, Domenico; Bonati, Laura, Current Topics in Medicinal Chemistry, 2013
Abstract: The biological function of proteins is strictly related to their molecular flexibility and dynamics: enzymatic activity, protein-protein interactions, ligand binding and allosteric regulation are important mechanisms involving protein motions. Computational approaches, such ...
Ontologies in Medicinal Chemistry: Current Status and Future Challenges
08-05-2013 | Gomez-Perez, Asuncion; Martinez-Romero, Marcos; Rodriguez-Gonzalez, Alejandro; Vazquez, Guillermo; Vazquez-Naya, Jose M., Current Topics in Medicinal Chemistry, 2013
Abstract: Recent years have seen a dramatic increase in the amount and availability of data in the diverse areas of medicinal chemistry, making it possible to achieve significant advances in fields such as the design, synthesis and biological evaluation of compounds. However, with this ...
MIANN Models in Medicinal, Physical and Organic Chemistry
08-05-2013 | Gonzalez-Diaz, Humberto; Arrasate, Sonia; Sotomayor, Nuria; Lete, Esther; R Munteanu, Cristian; Pazos, Alejandro; Be ..., Current Topics in Medicinal Chemistry, 2013
Abstract: Reducing costs in terms of time, animal sacrifice, and material resources with computational methods has become a promising goal in Medicinal, Biological, Physical and Organic Chemistry. There are many computational techniques that can be used in this sense. In any case, ...
Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents
07-05-2013 | Moni Sharma; Kuldeep Chauhan; Rahul Shivahare; Preeti Vishwakarma; Manish K. Suthar; Abhisheak Sharma; Suman Gupta; ..., Journal of Medicinal Chemistry, 2013
The high potential of quinazolinone containing natural products and their derivatives in medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone based on the concept of molecular hybridization. Most of the synthesized analogues exhibited potent leishmanicidal ...
Development of peptidomimetic boronates as proteasome inhibitors
06-05-2013 | Author(s): Nicola Micale , Roberta Ettari , Antonio Lavecchia , Carmen Di Giovanni , Kety Scarbaci , Valeria T ..., European Journal of Medicinal Chemistry, 2013
Publication date: June 2013Source:European Journal of Medicinal Chemistry, Volume 64 Author(s): Nicola Micale , Roberta Ettari , Antonio Lavecchia , Carmen Di Giovanni , Kety Scarbaci , Valeria Troiano , Silvana Grasso , Ettore Novellino , Tanja Schirmeister , Maria Zappalà ...
Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives
06-05-2013 | Author(s): Qingchao Liu , Hongchun Liu , Lei Zhang , Tiantian Guo , Peng Wang , Meiyu Geng , Yingxia Li, European Journal of Medicinal Chemistry, 2013
Publication date: June 2013Source:European Journal of Medicinal Chemistry, Volume 64 Author(s): Qingchao Liu , Hongchun Liu , Lei Zhang , Tiantian Guo , Peng Wang , Meiyu Geng , Yingxia Li Twenty-six naturally occurring oleanolic acid saponins and their derivatives, 16 of which ...
Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation
06-05-2013 | Author(s): Dahong Li , Shengtao Xu , Hao Cai , Lingling Pei , Hengyuan Zhang , Lei Wang , Hequan Yao , Xiaomi ..., European Journal of Medicinal Chemistry, 2013
Publication date: June 2013Source:European Journal of Medicinal Chemistry, Volume 64 Author(s): Dahong Li , Shengtao Xu , Hao Cai , Lingling Pei , Hengyuan Zhang , Lei Wang , Hequan Yao , Xiaoming Wu , Jieyun Jiang , Yijun Sun , Jinyi Xu A series of enmein-type diterpenoid ...
Novel 3,5-bis(arylidene)-4-piperidone dimers: Potent cytotoxins against colon cancer cells
06-05-2013 | Author(s): Swagatika Das , Umashankar Das , Deborah Michel , Dennis K.J. Gorecki , Jonathan R. Dimmock, European Journal of Medicinal Chemistry, 2013
Publication date: June 2013Source:European Journal of Medicinal Chemistry, Volume 64 Author(s): Swagatika Das , Umashankar Das , Deborah Michel , Dennis K.J. Gorecki , Jonathan R. Dimmock Two novel series of dimeric 3,5-bis(arylidene)-4-piperidones 7 and 8 were prepared as cytotoxic ...
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