25-03-2013 | Hanxiang Zeng; Hannah C. Little; Timothy N. Tiambeng; Gregory A. Williams; Zhibin Guan, Journal of the American Chemical Society, 2013

In this study, we designed and synthesized a biodegradable dendronized polypeptide (denpol) platform for delivery of small interfering RNA (siRNA). The novel denpol architecture combines the multivalency of dendrimers and conformational flexibility of linear polymers for optimal siRNA ...

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25-03-2013 | Cao, Yu ; Qi, Suijian ; Zhang, Yang ; Wang, Xiaoning ; Yang, Bo ; Wang, Yonghua, Molecules, 2013

Structured lipids (SLCTs triacylglycerols with short- and long-chain acyl residues) were synthesized by interesterification of triacetin and fatty acid methyl esters (FAMEs) from camellia oil, followed by molecular distillation for purification. Different commercial immobilized lipases ...

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21-03-2013 | Susanna Cogoi; Andrey E. Shchekotikhin; Alexandro Membrino; Yuri B. Sinkevich; Luigi E. Xodo, Journal of Medicinal Chemistry, 2013

We prepared a series of anthrathiophenediones (ATPDs) with guanidino-alkyl side chains of different length (compounds 1, 10–13). The aim was to investigate their interaction with DNA and RNA G-quadruplexes, their uptake in malignant and nonmalignant cells, and their capacity to modulate gene ...

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21-03-2013 | Wadman, Meredith;, Nature, 2013

Time called on chimp work Nature 495, 7441 (2013). http://www.nature.com/doifinder/10.1038/495289a Author: Meredith Wadman NIH likely to retire hundreds of government-owned chimpanzees.

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28-02-2013 | Hong Li, Yi Jia, Mingchun Du, Jinbo Fei, Jie Zhao, Yue Cui, Junbai Li, Chemistry - A European Journal, 2013

Abstract This study describes a facile breath‐figure method for the preparation of honeycomb‐like porous TiO2 films with an organometallic small‐molecule precursor. Multiple characterization techniques have been used to investigate the porous films and a mechanism for the formation ...

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12-02-2013 | Andreas Koeberle; Hideo Shindou; Solveigh C. Koeberle; Stefan A. Laufer; Takao Shimizu; Oliver Werz, Proceedings of the National Academy of Sciences current issue, 2013

The activity of protein kinase B (Akt)—a major kinase promoting cell proliferation and survival—oscillates during the cell cycle. To investigate whether membrane phospholipids may regulate Akt phosphorylation and thus activity, we monitored the lipid profile of nocodazole-synchronized mouse ...

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11-02-2013 | Omar Moukha-chafiq; Robert C. Reynolds, Journal of Combinatorial Chemistry, 2013

A library of eighty one adenosine antibiotic analogs was prepared under the Pilot Scale Library Program of the NIH Roadmap initiative from 5′-amino-5′-deoxy-2′,3′-O-isopropylidene-adenosine 3. Diverse aldehyde, sulfonyl chloride and carboxylic acid reactant sets were condensed to 3, in ...

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07-02-2013 | An, Na ; Ou, Jiquan ; Jiang, Daiming ; Zhang, Liping ; Liu, Jingru ; Fu, Kai ; Dai, Ying ; Yang, Daichang, International Journal of Molecular Sciences, 2013

Basic fibroblast growth factor (FGF-2) is an important member of the FGF gene family. It is widely used in clinical applications for scald and wound healing in order to stimulate cell proliferation. Further it is applied for inhibiting stem cell differentiation in cultures. Due to a shortage ...

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05-02-2013 | Jocelyn Kaiser, Science , 2013

Most chimps owned by the National Institutes of Health could be headed for retirement.

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31-01-2013 | Corey R. Hopkins, et al. et al., ChemInform, 2013

Abstract Compound (I) is identified as a potent activator of KCNQ1 channels using a high‐throughput screen of the NIH Molecular Library Small Molecule Repository.

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