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Off‐target effects of engineered nucleases

21-May-2016 | Jiing‐Kuan Yee, FEBS Journal, 2016

Abstract Recent advances in gene editing with engineered nucleases have transformed our ability to manipulate the genome from diverse organisms for applications ranging from biomedical research to disease treatment. A major complication with these engineered nucleases is the binding of the ...


High‐Performance Multifunctional Thermoplastic Composites Enhanced by Aligned Buckypaper 

20-May-2016 | Zhongrui Li, Jin Gyu Park, Zhiyong Liang, Advanced Engineering Materials, 2016

High‐performance lightweight composites are sizably manufactured by impregnating continuous aligned carbon nanotube sheet (buckypapers) with self‐reinforcing polyphenylene (Parmax) solution and followed by hot‐press. The high processing pressure flattens nanotubes, which preferably π‐stack with ...


IJMS, Vol. 17, Pages 732: Degree of Conversion and BisGMA, TEGDMA, UDMA Elution from Flowable Bulk Fill Composites

20-May-2016 | Lempel, Edina ; Czibulya, Zsuzsanna ; Kovács, Bálint ; Szalma, József ; Tóth, Ákos ; Kunsági-Máté, Sándor ; Varga, Z ..., International Journal of Molecular Sciences, 2016

The degree of conversion (DC) and the released bisphenol A diglycidyl ether dimethacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) monomers of bulk-fill composites compared to that of conventional flowable ones were assessed using micro-Raman ...


A morphological study on the migration and selective localization of graphene in the PLA/PMMA blends

18-May-2016 | Azin Paydayesh, Ahmad Arefazar, Azam Jalaliarani, Journal of Applied Polymer Science, 2016

ABSTRACT Nano‐filled polymer blends offer the opportunity to obtain materials with fine‐tuned properties. In this work, the dispersion and localization behavior of graphene nanoplate (GNP) and graphene oxide (GO) in solution mixed blends of polylactic acid (PLA) and polymethyl methacrylate ...


Molecules, Vol. 21, Pages 658: Cytotoxicity of Different Excipients on RPMI 2650 Human Nasal Epithelial Cells

18-May-2016 | Horváth, Tamás ; Bartos, Csilla ; Bocsik, Alexandra ; Kiss, Lóránd ; Veszelka, Szilvia ; Deli, Mária A.; Újhelyi, Ga ..., Molecules, 2016

The nasal route receives a great deal of attention as a non-invasive method for the systemic administration of drugs. For nasal delivery, specific formulations containing excipients are used. Because of the sensitive respiratory mucosa, not only the active ingredients, but also additives need to ...


Protein‐Framed Multi‐Porphyrin Micelles for a Hybrid Natural–Artificial Light‐Harvesting Nanosystem

17-May-2016 | Yannan Liu, Jiyang Jin, Hongping Deng, Ke Li, Yongli Zheng, Chunyang Yu, Yongfeng Zhou, Angewandte Chemie International Edition, 2016

Abstract A micelle‐like hybrid natural–artificial light‐harvesting nanosystem was prepared through protein‐framed electrostatic self‐assembly of phycocyanin and a four‐armed porphyrin star polymer. The nanosystem has a special structure of pomegranate‐like unimolecular micelle aggregate with ...


A Disposable Planar Paper‐Based Potentiometric Ion‐Sensing Platform

17-May-2016 | Jinbo Hu, Andreas Stein, Philippe Bühlmann, Angewandte Chemie International Edition, 2016

Abstract Ion‐selective electrodes (ISEs) are widely used tools for fast and accurate ion sensing. Herein their design is simplified by embedding a potentiometric cell into paper, complete with an ISE, a reference electrode, and a paper‐based microfluidic sample zone that offer the full ...


Study retention as bias reduction in a hard-to-reach population [Social Sciences]

17-May-2016 | Bruce Western; Anthony Braga; David Hureau; Catherine Sirois, Proceedings of the National Academy of Sciences current issue, 2016

Collecting data from hard-to-reach populations is a key challenge for research on poverty and other forms of extreme disadvantage. With data from the Boston Reentry Study (BRS), we document the extreme marginality of released prisoners and the related difficulties of study retention and analysis. ...


Giant Electric-Field-Induced Strain in PVDF-Based Battery Separator Membranes Probed by Electrochemical Strain Microscopy

17-May-2016 | Konstantin Romanyuk; Carlos M. Costa; Sergey Yu. Luchkin; Andrei L. Kholkin; Senentxu Lanceros-Méndez, Langmuir, 2016

Efficiency of lithium-ion batteries largely relies on the performance of battery separator membrane as it controls the mobility and concentration of Li-ions between the anode and cathode electrodes. Recent advances in electrochemical strain microscopy (ESM) prompted the study of Li diffusion and ...


Sensors, Vol. 16, Pages 706: A Plasmonic Temperature-Sensing Structure Based on Dual Laterally Side-Coupled Hexagonal Cavities

17-May-2016 | Xie, Yiyuan ; Huang, Yexiong ; Xu, Weihua ; Zhao, Weilun ; He, Chao, Sensors, 2016

A plasmonic temperature-sensing structure, based on a metal-insulator-metal (MIM) waveguide with dual side-coupled hexagonal cavities, is proposed and numerically investigated by using the finite-difference time-domain (FDTD) method in this paper. The numerical simulation results show that a ...


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