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An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers

03-Sep-2015 | Nadine Frost; Maureen McKeague; Darren Falcioni; Maria DeRosa, Analyst, 2015

Aptamers are short single-stranded oligonucleotides that fold into unique three-dimensional structures, facilitating selective and high affinity binding to their cognate targets. It is not well understood how aptamer-target interactions affect regions of structure in an aptamer, particularly for ...

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Sensors, Vol. 15, Pages 21219-21238: Inferring Human Activity in Mobile Devices by Computing Multiple Contexts

28-Aug-2015 | Chen, Ruizhi ; Chu, Tianxing ; Liu, Keqiang ; Liu, Jingbin ; Chen, Yuwei, Sensors, 2015

This paper introduces a framework for inferring human activities in mobile devices by computing spatial contexts, temporal contexts, spatiotemporal contexts, and user contexts. A spatial context is a significant location that is defined as a geofence, which can be a node associated with a circle, ...

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Gas‐phase fragmentation of the N‐oxide and N‐hydroxylated derivatives of retrorsine using liquid chromatography/electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry

27-Aug-2015 | Farid Jahouh, Fabio Marongiu, Maria Paola Serra, Ezio Laconi, Joseph Banoub, Rapid Communications in Mass Spectrometry, 2015

Rationale We report the electrospray ionization mass spectrometry and low‐energy collision‐induced dissociation tandem mass spectrometry (CID‐MS/MS) analysis of a pyrrolizidine alkaloid extract containing both retrorsine [C18H25NO6] and its N‐oxide [C18H25NO7] and N‐hydroxyl [C18H26NO7] ...

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Sensors, Vol. 15, Pages 21114-21133: Embedded Vision Sensor Network for Planogram Maintenance in Retail Environments

27-Aug-2015 | Frontoni, Emanuele ; Mancini, Adriano ; Zingaretti, Primo, Sensors, 2015

A planogram is a detailed visual map that establishes the position of the products in a retail store. It is designed to supply the best location of a product for suppliers to support an innovative merchandising approach, to increase sales and profits and to better manage the shelves. Deviating ...

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Sensors, Vol. 15, Pages 21033-21053: A Combination of Genetic Algorithm and Particle Swarm Optimization for Vehicle Routing Problem with Time Windows

27-Aug-2015 | Xu, Sheng-Hua ; Liu, Ji-Ping ; Zhang, Fu-Hao ; Wang, Liang ; Sun, Li-Jian, Sensors, 2015

A combination of genetic algorithm and particle swarm optimization (PSO) for vehicle routing problems with time windows (VRPTW) is proposed in this paper. The improvements of the proposed algorithm include: using the particle real number encoding method to decode the route to alleviate the ...

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Defect density associated with constituent particles in AA2024‐T3 and its role in corrosion

26-Aug-2015 | Alexander M. Glenn, Anthony E. Hughes, Aaron Torpy, Gert Nolze, Nick Birbilis, Surface and Interface Analysis, 2015

Electron backscatter diffraction (EBSD) and scanning electron microscopy were combined to study the effect of residual defect density on corrosion initiation in aluminium alloy AA2024‐T3. EBSD was used to determine the level of misorientation (MO), from pixel to pixel, within individual grains. ...

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Determination of metal ion concentrations by SERS using 2,2'-bipyridyl complexes

26-Aug-2015 | Julie Ann Docherty; Samuel Mabbott; Ewen Smith; John Reglinski; Karen Faulds; Christine Davidson; Duncan Graham, Analyst, 2015

Surface enhanced Raman scattering (SERS) can generate characteristic spectral “fingerprints” from metal complexes, thus providing the potential for the development of methods of analysis for the identification and quantitation of a range of metal ions in solution. The advantages include ...

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Sensors, Vol. 15, Pages 20990-21015: Development of a Conductivity Sensor for Monitoring Groundwater Resources to Optimize Water Management in Smart City Environments

26-Aug-2015 | Parra, Lorena ; Sendra, Sandra ; Lloret, Jaime ; Bosch, Ignacio, Sensors, 2015

The main aim of smart cities is to achieve the sustainable use of resources. In order to make the correct use of resources, an accurate monitoring and management is needed. In some places, like underground aquifers, access for monitoring can be difficult, therefore the use of sensors can be a ...

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Manganese oxide nanoparticles/reduced graphene oxide as novel electrochemical platform for immobilization of FAD and its application as highly sensitive persulfate sensor

24-Aug-2015 | Samira Mansouri Majd, Abdollah Salimi, Bandar Astinchap, Electroanalysis, 2015

Abstract In this study, manganese oxide nanoparticles/reduced graphene oxide(MnOxNPs/rGO) was used as support for strong immobilization of flavin adenine dinucleotide(FAD). A thin film of rGO cast on the electrode surface, followed by performing electrodeposition of MnOxNPs at applied constant ...

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A shifted‐excitation Raman difference spectroscopy (SERDS) evaluation strategy for the efficient isolation of Raman spectra from extreme fluorescence interference

24-Aug-2015 | Medhanie Tesfay Gebrekidan, Christian Knipfer, Florian Stelzle, Juergen Popp, Stefan Will, Andreas Braeuer, Journal of Raman Spectroscopy, 2015

A biochemical characterization of pathologies in biological tissue can be provided by Raman spectroscopy. Often, the raw spectrum is severely affected by fluorescence interference. We report and compare various spectra‐processing approaches required for the purification of Raman spectra from ...

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