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Metformin and respiratory chain complex I: the last piece of the puzzle?

01-11-2014 | Fontaine E, Biochemical Journal, 2014

Metformin is the most widely prescribed drug used to treat patients affected by Type2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to complex I ...


NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...


Evaluation of the Role of G Protein-Coupled Receptor Kinase 3 in Desensitization of Mouse Odorant Receptors in a Mammalian Cell Line and in Olfactory Sensory Neurons

01-11-2014 | Aya Kato; Johannes Reisert; Sayoko Ihara; Keiichi Yoshikawa; Kazushige Touhara, Chemical Senses, 2014

Thousands of odors are sensed and discriminated by G protein-coupled odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs). G protein-coupled receptor kinases (GRKs) may have a role in desensitization of ORs. However, whether ORs are susceptible to agonist-dependent ...


Evidence that Humans Can Taste Glucose Polymers

01-11-2014 | Trina J. Lapis; Michael H. Penner; Juyun Lim, Chemical Senses, 2014

The sense of taste is essential for identifying potential nutrients and poisons. Accordingly, specialized taste receptor cells are activated by food-derived chemicals. Because of its importance in the human diet, oral detection of starch, or its degradation products, would presumably be highly ...


Using Sniffing Behavior to Differentiate True Negative from False Negative Responses in Trained Scent-Detection Dogs

01-11-2014 | Astrid Concha; Daniel S. Mills; Alexandre Feugier; Helen Zulch; Claire Guest; Rob Harris; Thomas W. Pike, Chemical Senses, 2014

False negatives are recorded in every chemical detection system, but when animals are used as a scent detector, some false negatives can arise as a result of a failure in the link between detection and the trained alert response, or a failure of the handler to identify the positive alert. A false ...


A Determinant of Odorant Specificity Is Located at the Extracellular Loop 2-Transmembrane Domain 4 Interface of an Anopheles gambiae Odorant Receptor Subunit

01-11-2014 | David T. Hughes; Guirong Wang; Laurence J. Zwiebel; Charles W. Luetje, Chemical Senses, 2014

To explore the structural basis for odorant specificity in odorant receptors of the human malaria vector mosquito, Anopheles gambiae, odorant-binding subunits (Agam\Ors) expressed in Xenopus oocytes in combination with Agam\Orco (coreceptor subunit) were assayed by 2-electrode voltage clamp ...


Gray Matter Volume Reduction of Olfactory Cortices in Patients With Idiopathic Olfactory Loss

01-11-2014 | Linyin Yao; Jayant Marian Pinto; Xiaoli Yi; Li Li; Peng Peng; Yongxiang Wei, Chemical Senses, 2014

Idiopathic olfactory loss (IOL) is a common olfactory disorder. Little is known about the pathophysiology of this disease. Previous studies demonstrated decreased olfactory bulb (OB) volume in IOL patients when compared with controls. The aim of our study was to investigate structural brain ...


Sodium Aspartate as a Specific Enhancer of Salty Taste Perception—Sodium Aspartate Is a Possible Candidate to Decrease Excessive Intake of Dietary Salt

01-11-2014 | Tomohiro Nakagawa; Jun Kohori; Shin Koike; Yoshihisa Katsuragi; Takayuki Shoji, Chemical Senses, 2014

The excessive intake of dietary salt is a global issue in health. Attempts have been made to address this issue, including the development of salt substitutes. Yet, none of these substances are currently in wide use, because of their weak saltiness. The purpose of this study was to assess the ...


Effect of Cationic Head Group on Micellization Behavior of New Amide Functionalized Surface Active Ionic Liquids

22-10-2014 | Raman Kamboj; Pankaj Bharmoria; Vinay Chauhan; Gurbir Singh; Arvind Kumar; Sukhprit Singh; Tejwant Singh Kang, Physical Chemistry Chemical Physics, 2014

Amide functionalized surface active ionic liquids (SAILs), 1-methyl-1-dodecyl pipyridinium chloride, [C12APip][Cl], 1-methyl-1-dodecyl pyrrolidinium chloride, [C12APyrr][Cl], 1-methyl-3-dodecyl imidazolium chloride, [C12Amim][Cl], and 1-methyl-1-dodecyl morpholinium chloride, [C12AMorph][Cl] have ...


Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

22-10-2014 | Wye-Khay Fong; Tracey L. Hanley; Benjamin Thierry; Adam Tilley; Nigel Kirby; Lynne J. Waddington; Ben J. Boyd, Physical Chemistry Chemical Physics, 2014

Lipid-based liquid crystalline systems are showing potential as stimuli-responsive nanomaterials, and NIR-responsive gold nanoparticles have been demonstrated to provide control of transitions in non-lamellar phases. In this study, we focus on a deeper understanding of the photothermal response ...


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