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[Report] Multidimensional hierarchical self-assembly of amphiphilic cylindrical block comicelles

20-Mar-2015 | Huibin Qiu; Zachary M. Hudson; Mitchell A. Winnik; Ian Manners, Science , 2015

Self-assembly of molecular and block copolymer amphiphiles represents a well-established route to micelles with a wide variety of shapes and gel-like phases. We demonstrate an analogous process, but on a longer length scale, in which amphiphilic P-H-P and H-P-H cylindrical triblock comicelles ...

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Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution [Biochemistry]

17-Mar-2015 | Matthias Hillenbrand; Christian Schori; Jendrik Schöppe; Andreas Plückthun, Proceedings of the National Academy of Sciences current issue, 2015

Agonist binding to G-protein–coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the details of interaction with the different ...

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DNA Base Pair Resolution Measurements Using Resonance Energy Transfer Efficiency in Lanthanide Doped Nanoparticles

06-Mar-2015 | Aleksandra Delplanque et al., PLoS ONE, 2015

by Aleksandra Delplanque, Dominika Wawrzynczyk, Pawel Jaworski, Katarzyna Matczyszyn, Krzysztof Pawlik, Malcolm Buckle, Marcin Nyk, Claude Nogues, Marek Samoc Lanthanide-doped nanoparticles are of considerable interest for biodetection and bioimaging techniques thanks to their unique chemical ...

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[Perspective] A return to the pre-antimicrobial era?

06-Mar-2015 | Stephen Baker, Science , 2015

After many years out of the limelight, antimicrobial resistance (AMR) in bacteria is firmly back on the international political and scientific agenda (1, 2). The potential impact of AMR on hospital-acquired bacterial infections such as Staphylococcus aureus and Acinetobacter baumannii in ...

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[Perspective] Single proteins under a diamond spotlight

06-Mar-2015 | Philip Hemmer; Carmen Gomes, Science , 2015

Proteins are the workhorse of life. They assemble the structural elements of the cell, catalyze metabolism, regulate cellular functions, and even transcribe and repair DNA. Many of the proteins' functions are related to their physical shape and conformations. For example, protein-folding problems ...

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Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice

01-Mar-2015 | Bote G Bruinsma; Korkut Uygun; Martin L Yarmush; Nima Saeidi, Nature Protocols, 2015

Nature Protocols 10, 495 (2015). doi:10.1038/nprot.2015.027 Authors: Bote G Bruinsma, Korkut Uygun, Martin L Yarmush & Nima Saeidi Bariatric surgery is the only definitive solution currently available for the present obesity pandemic. These operations typically involve ...

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Conformational Changes in a Hyperthermostable Glycoside Hydrolase: Enzymatic Activity Is a Consequence of the Loop Dynamics and Protonation Balance

27-Feb-2015 | Leandro C. de Oliveira et al., PLoS ONE, 2015

by Leandro C. de Oliveira, Viviam M. da Silva, Francieli Colussi, Aline D. Cabral, Mario de Oliveira Neto, Fabio M. Squina, Wanius Garcia Endo-β-1, 4-mannanase from Thermotoga petrophila (TpMan) is a modular hyperthermostable enzyme involved in the degradation of mannan-containing ...

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[Report] Electron-hole diffusion lengths > 175 μm in solution-grown CH3NH3PbI3 single crystals

27-Feb-2015 | Qingfeng Dong; Yanjun Fang; Yuchuan Shao; Padhraic Mulligan; Jie Qiu; Lei Cao; Jinsong Huang, Science , 2015

Long, balanced electron and hole diffusion lengths greater than 100 nanometers in the polycrystalline organolead trihalide compound CH3NH3PbI3 are critical for highly efficient perovskite solar cells. We found that the diffusion lengths in CH3NH3PbI3 single crystals grown by a solution-growth ...

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Energies, Vol. 8, Pages 1505-1528: Energy Coordinative Optimization of Wind-Storage-Load Microgrids Based on Short-Term Prediction

16-Feb-2015 | Hu, Changbin ; Luo, Shanna ; Li, Zhengxi ; Wang, Xin ; Sun, Li, Energies, 2015

According to the topological structure of wind-storage-load complementation microgrids, this paper proposes a method for energy coordinative optimization which focuses on improvement of the economic benefits of microgrids in the prediction framework. First of all, the external characteristic ...

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Catching the Missing Million: Experiences in Enhancing TB & DR-TB Detection by Providing Upfront Xpert MTB/RIF Testing for People Living with HIV in India

06-Feb-2015 | Neeraj Raizada et al., PLoS ONE, 2015

by Neeraj Raizada, Kuldeep Singh Sachdeva, Achuthan Sreenivas, Shubhangi Kulsange, Radhey Shyam Gupta, Rahul Thakur, Puneet Dewan, Catharina Boehme, Chinnambedu Nainarappan Paramsivan Background A critical challenge in providing TB care to People Living with HIV (PLHIV) is establishing an ...

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