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167 Newest Publications about the topic solution

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Importance of the DNA "bond" in programmable nanoparticle crystallization [Chemistry]

21-10-2014 | Robert J. Macfarlane; Ryan V. Thaner; Keith A. Brown; Jian Zhang; Byeongdu Lee; SonBinh T. Nguyen; Chad A. Mirkin, Proceedings of the National Academy of Sciences current issue, 2014

If a solution of DNA-coated nanoparticles is allowed to crystallize, the thermodynamic structure can be predicted by a set of structural design rules analogous to Pauling’s rules for ionic crystallization. The details of the crystallization process, however, have proved more difficult to ...

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Inner Workings: Roboclam [Inner Workings]

21-10-2014 | Calla Cofield, Proceedings of the National Academy of Sciences current issue, 2014

Digging in the sand might seem like child's play, but doing it efficiently has stumped many adult engineers. As is often the case, nature has revealed a superior solution: this time in the Atlantic razor clam, which can burrow into and out of sandy ocean bottoms more efficiently than man-made,...

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A cellular solution to an information-processing problem [Applied Physical Sciences]

26-08-2014 | Garud Iyengar; Madan Rao, Proceedings of the National Academy of Sciences current issue, 2014

Signaling receptors on the cell surface are mobile and have evolved to efficiently sense and process mechanical or chemical information. We pose the problem of identifying the optimal strategy for placing a collection of distributed and mobile sensors to faithfully estimate a signal that varies ...

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Structure of {beta}-galactosidase at 3.2-A resolution obtained by cryo-electron microscopy [Biophysics and Computational Biology]

12-08-2014 | Alberto Bartesaghi; Doreen Matthies; Soojay Banerjee; Alan Merk; Sriram Subramaniam, Proceedings of the National Academy of Sciences current issue, 2014

We report the solution structure of Escherichia coli β-galactosidase (∼465 kDa), solved at ∼3.2-Å resolution by using single-particle cryo-electron microscopy (cryo-EM). Densities for most side chains, including those of residues in the active site, and a catalytic Mg2+ ion can be discerned in ...

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The magnetoelectrochemical switch [Applied Physical Sciences]

22-07-2014 | Petru Lunca Popa; Neil T. Kemp; Hicham Majjad; Guillaume Dalmas; Vina Faramarzi; Christian Andreas; Riccardo Hertel; ..., Proceedings of the National Academy of Sciences current issue, 2014

In the field of spintronics, the archetype solid-state two-terminal device is the spin valve, where the resistance is controlled by the magnetization configuration. We show here how this concept of spin-dependent switch can be extended to magnetic electrodes in solution, by magnetic control of ...

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Synthesizing cognition in neuromorphic electronic systems [Engineering]

10-09-2013 | Emre Neftci; Jonathan Binas; Ueli Rutishauser; Elisabetta Chicca; Giacomo Indiveri; Rodney J. Douglas, Proceedings of the National Academy of Sciences current issue, 2013

The quest to implement intelligent processing in electronic neuromorphic systems lacks methods for achieving reliable behavioral dynamics on substrates of inherently imprecise and noisy neurons. Here we report a solution to this problem that involves first mapping an unreliable hardware layer of ...

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Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (A{beta}) peptide aggregation [Chemistry]

03-09-2013 | Ying Zhang; Don L. Rempel; Jun Zhang; Anuj K. Sharma; Liviu M. Mirica; Michael L. Gross, Proceedings of the National Academy of Sciences current issue, 2013

Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is challenging owing to the vast heterogeneity of the resulting soluble aggregates. To investigate the formation of these aggregates in solution, we designed an MS-based biophysical approach and applied it to the ...

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Isothermal amplification method for next-generation sequencing [Genetics]

27-08-2013 | Zhaochun Ma; Raymond W. Lee; Bin Li; Paul Kenney; Yufang Wang; Jonathan Erikson; Swati Goyal; Kaiqin Lao, Proceedings of the National Academy of Sciences current issue, 2013

We report an approach for generating immobilized monoclonal templates for next- generation sequencing applications. Our isothermal amplification method is based on a template walking mechanism using a pair of low-melting temperature (Tm) solid-surface homopolymer primers and a low-Tm solution ...

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Composability of regulatory sequences controlling transcription and translation in Escherichia coli [Systems Biology]

20-08-2013 | Sriram Kosuri; Daniel B. Goodman; Guillaume Cambray; Vivek K. Mutalik; Yuan Gao; Adam P. Arkin; Drew Endy; George M. ..., Proceedings of the National Academy of Sciences current issue, 2013

The inability to predict heterologous gene expression levels precisely hinders our ability to engineer biological systems. Using well-characterized regulatory elements offers a potential solution only if such elements behave predictably when combined. We synthesized 12,563 combinations of common ...

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Large population solution of the stochastic Luria-Delbruck evolution model [Evolution]

16-07-2013 | David A. Kessler; Herbert Levine, Proceedings of the National Academy of Sciences current issue, 2013

Luria and Delbrück introduced a very useful and subsequently widely adopted framework for quantitatively understanding the emergence of new cellular lineages. Here, we provide an analytical treatment of the fully stochastic version of the model, enabled by the fact that population sizes at the ...

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