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165 Newest Publications about the topic solution

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A cellular solution to an information-processing problem [Applied Physical Sciences]

26-08-2014 | Garud Iyengar; Madan Rao, Proceedings of the National Academy of Sciences current issue, 2014

Signaling receptors on the cell surface are mobile and have evolved to efficiently sense and process mechanical or chemical information. We pose the problem of identifying the optimal strategy for placing a collection of distributed and mobile sensors to faithfully estimate a signal that varies ...

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Structure of {beta}-galactosidase at 3.2-A resolution obtained by cryo-electron microscopy [Biophysics and Computational Biology]

12-08-2014 | Alberto Bartesaghi; Doreen Matthies; Soojay Banerjee; Alan Merk; Sriram Subramaniam, Proceedings of the National Academy of Sciences current issue, 2014

We report the solution structure of Escherichia coli β-galactosidase (∼465 kDa), solved at ∼3.2-Å resolution by using single-particle cryo-electron microscopy (cryo-EM). Densities for most side chains, including those of residues in the active site, and a catalytic Mg2+ ion can be discerned in ...

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The magnetoelectrochemical switch [Applied Physical Sciences]

22-07-2014 | Petru Lunca Popa; Neil T. Kemp; Hicham Majjad; Guillaume Dalmas; Vina Faramarzi; Christian Andreas; Riccardo Hertel; ..., Proceedings of the National Academy of Sciences current issue, 2014

In the field of spintronics, the archetype solid-state two-terminal device is the spin valve, where the resistance is controlled by the magnetization configuration. We show here how this concept of spin-dependent switch can be extended to magnetic electrodes in solution, by magnetic control of ...

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Synthesizing cognition in neuromorphic electronic systems [Engineering]

10-09-2013 | Emre Neftci; Jonathan Binas; Ueli Rutishauser; Elisabetta Chicca; Giacomo Indiveri; Rodney J. Douglas, Proceedings of the National Academy of Sciences current issue, 2013

The quest to implement intelligent processing in electronic neuromorphic systems lacks methods for achieving reliable behavioral dynamics on substrates of inherently imprecise and noisy neurons. Here we report a solution to this problem that involves first mapping an unreliable hardware layer of ...

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Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (A{beta}) peptide aggregation [Chemistry]

03-09-2013 | Ying Zhang; Don L. Rempel; Jun Zhang; Anuj K. Sharma; Liviu M. Mirica; Michael L. Gross, Proceedings of the National Academy of Sciences current issue, 2013

Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is challenging owing to the vast heterogeneity of the resulting soluble aggregates. To investigate the formation of these aggregates in solution, we designed an MS-based biophysical approach and applied it to the ...

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Isothermal amplification method for next-generation sequencing [Genetics]

27-08-2013 | Zhaochun Ma; Raymond W. Lee; Bin Li; Paul Kenney; Yufang Wang; Jonathan Erikson; Swati Goyal; Kaiqin Lao, Proceedings of the National Academy of Sciences current issue, 2013

We report an approach for generating immobilized monoclonal templates for next- generation sequencing applications. Our isothermal amplification method is based on a template walking mechanism using a pair of low-melting temperature (Tm) solid-surface homopolymer primers and a low-Tm solution ...

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Composability of regulatory sequences controlling transcription and translation in Escherichia coli [Systems Biology]

20-08-2013 | Sriram Kosuri; Daniel B. Goodman; Guillaume Cambray; Vivek K. Mutalik; Yuan Gao; Adam P. Arkin; Drew Endy; George M. ..., Proceedings of the National Academy of Sciences current issue, 2013

The inability to predict heterologous gene expression levels precisely hinders our ability to engineer biological systems. Using well-characterized regulatory elements offers a potential solution only if such elements behave predictably when combined. We synthesized 12,563 combinations of common ...

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Large population solution of the stochastic Luria-Delbruck evolution model [Evolution]

16-07-2013 | David A. Kessler; Herbert Levine, Proceedings of the National Academy of Sciences current issue, 2013

Luria and Delbrück introduced a very useful and subsequently widely adopted framework for quantitatively understanding the emergence of new cellular lineages. Here, we provide an analytical treatment of the fully stochastic version of the model, enabled by the fact that population sizes at the ...

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Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR [Biophysics and Computational Biology]

09-07-2013 | David S. Libich; Nicolas L. Fawzi; Jinfa Ying; G. Marius Clore, Proceedings of the National Academy of Sciences current issue, 2013

The mechanism whereby the prototypical chaperonin GroEL performs work on substrate proteins has not yet been fully elucidated, hindered by lack of detailed structural and dynamic information on the bound substrate. Previous investigations have produced conflicting reports on the state of ...

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Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake [Cell Biology]

02-07-2013 | Shengjie Feng; Hongyu Li; Yilin Tai; Junbo Huang; Yujuan Su; Joel Abramowitz; Michael X. Zhu; Lutz Birnbaumer; Yizhe ..., Proceedings of the National Academy of Sciences current issue, 2013

Mitochondrial Ca2+ homeostasis is fundamental to regulation of mitochondrial membrane potential, ATP production, and cellular Ca2+ homeostasis. It has been known for decades that isolated mitochondria can take up Ca2+ from the extramitochondrial solution, but the molecular identity of the Ca2+ ...

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