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205 Newest Publications about the topic solution

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One-pot system for synthesis, assembly, and display of functional single-span membrane proteins on oil-water interfaces [Applied Physical Sciences]

19-Jan-2016 | Peter J. Yunker; Haruichi Asahara; Kuo-Chan Hung; Corey Landry; Laura R. Arriaga; Ilke Akartuna; John Heyman; Shaoro ..., Proceedings of the National Academy of Sciences current issue, 2016

Single-span membrane proteins (ssMPs) represent approximately one-half of all membrane proteins and play important roles in cellular communications. However, like all membrane proteins, ssMPs are prone to misfolding and aggregation because of the hydrophobicity of transmembrane helices, making ...

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Samuel Frederick Edwards: Founder of modern polymer and soft matter theory [Retrospective]

05-Jan-2016 | Nigel Goldenfeld, Proceedings of the National Academy of Sciences current issue, 2016

This year marks the 50th anniversary of the seminal paper by Sam Edwards on the statistical mechanics of a single polymer chain in dilute solution, a paper that in one stroke founded the modern quantitative understanding of polymer matter, and vaulted soft condensed matter on to the stage of ...

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Limitations of GCTA as a solution to the missing heritability problem [Genetics]

05-Jan-2016 | Siddharth Krishna Kumar; Marcus W. Feldman; David H. Rehkopf; Shripad Tuljapurkar, Proceedings of the National Academy of Sciences current issue, 2016

Genome-wide association studies (GWASs) seek to understand the relationship between complex phenotype(s) (e.g., height) and up to millions of single-nucleotide polymorphisms (SNPs). Early analyses of GWASs are commonly believed to have “missed” much of the additive genetic variance estimated from ...

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Protein-like proton exchange in a synthetic host cavity [Chemistry]

15-Dec-2015 | William M. Hart-Cooper; Carmelo Sgarlata; Charles L. Perrin; F. Dean Toste; Robert G. Bergman; Kenneth N. Raymond, Proceedings of the National Academy of Sciences current issue, 2015

The mechanism of proton exchange in a metal–ligand enzyme active site mimic (compound 1) is described through amide hydrogen–deuterium exchange kinetics. The type and ratio of cationic guest to host in solution affect the rate of isotope exchange, suggesting that the rate of exchange is driven by ...

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Reply to Marchenko et al.: Flux analysis of GroEL-assisted protein folding/unfolding [Biological Sciences]

15-Dec-2015 | David S. Libich; Vitali Tugarinov; G. Marius Clore, Proceedings of the National Academy of Sciences current issue, 2015

Using NMR-based relaxation experiments, we showed that exchange between the folded state (F) of a metastable SH3 domain and a folding intermediate (I) is an order of magnitude faster when the SH3 domain is bound to apo GroEL than in free solution (1). We did not consider fluxes through the...

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Formamide reaction network in gas phase and solution via a unified theoretical approach: Toward a reconciliation of different prebiotic scenarios [Chemistry]

08-Dec-2015 | Fabio Pietrucci; Antonino Marco Saitta, Proceedings of the National Academy of Sciences current issue, 2015

Increasing experimental and theoretical evidence points to formamide as a possible hub in the complex network of prebiotic chemical reactions leading from simple precursors like H2, H2O, N2, NH3, CO, and CO2 to key biological molecules like proteins, nucleic acids, and sugars. We present an ...

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Low-cost solution to the grid reliability problem with 100% penetration of intermittent wind, water, and solar for all purposes [Sustainability Science]

08-Dec-2015 | Mark Z. Jacobson; Mark A. Delucchi; Mary A. Cameron; Bethany A. Frew, Proceedings of the National Academy of Sciences current issue, 2015

This study addresses the greatest concern facing the large-scale integration of wind, water, and solar (WWS) into a power grid: the high cost of avoiding load loss caused by WWS variability and uncertainty. It uses a new grid integration model and finds low-cost, no-load-loss, nonunique solutions ...

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Opinion: To feed the world in 2050 will require a global revolution [Opinion]

01-Dec-2015 | Paul R. Ehrlich; John Harte, Proceedings of the National Academy of Sciences current issue, 2015

Achieving universal food security is a staggering challenge, especially in a world with an expanding population, accelerating consumption, and many signals of a deteriorating global environment (1). Some claim that population size and growth are irrelevant, and that the solution is a more ...

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Ultrahigh electrical conductivity in solution-sheared polymeric transparent films [Applied Physical Sciences]

17-Nov-2015 | Brian J. Worfolk; Sean C. Andrews; Steve Park; Julia Reinspach; Nan Liu; Michael F. Toney; Stefan C. B. Mannsfeld; Z ..., Proceedings of the National Academy of Sciences current issue, 2015

With consumer electronics transitioning toward flexible products, there is a growing need for high-performance, mechanically robust, and inexpensive transparent conductors (TCs) for optoelectronic device integration. Herein, we report the scalable fabrication of highly conductive ...

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Teleportation of entanglement over 143 km [Physics]

17-Nov-2015 | Thomas Herbst; Thomas Scheidl; Matthias Fink; Johannes Handsteiner; Bernhard Wittmann; Rupert Ursin; Anton Zeilinger, Proceedings of the National Academy of Sciences current issue, 2015

As a direct consequence of the no-cloning theorem, the deterministic amplification as in classical communication is impossible for unknown quantum states. This calls for more advanced techniques in a future global quantum network, e.g., for cloud quantum computing. A unique solution is the ...

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