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211 Newest Publications about the topic solution

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Enhanced gene targeting to evaluate Lynch syndrome alterations [Genetics]

12-Apr-2016 | Richard Fishel; Christopher D. Heinen, Proceedings of the National Academy of Sciences current issue, 2016

The identification of gene alterations that predispose individuals to disease has resulted in an explosion in genetic diagnostics. Because diseases like cancer susceptibility may result in debilitating surgery that has physical, emotional, and realized costs, it is important to get the diagnosis ...

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Stokes trap for multiplexed particle manipulation and assembly using fluidics [Biophysics and Computational Biology]

12-Apr-2016 | Anish Shenoy; Christopher V. Rao; Charles M. Schroeder, Proceedings of the National Academy of Sciences current issue, 2016

The ability to confine and manipulate single particles and molecules has revolutionized several fields of science. Hydrodynamic trapping offers an attractive method for particle manipulation in free solution without the need for optical, electric, acoustic, or magnetic fields. Here, we develop ...

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Conservation triage or injurious neglect in endangered species recovery [Ecology]

29-Mar-2016 | Leah R. Gerber, Proceedings of the National Academy of Sciences current issue, 2016

Listing endangered and threatened species under the US Endangered Species Act is presumed to offer a defense against extinction and a solution to achieve recovery of imperiled populations, but only if effective conservation action ensues after listing occurs. The amount of government funding ...

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Origin and prediction of free-solution interaction studies performed label-free [Chemistry]

22-Mar-2016 | Darryl J. Bornhop; Michael N. Kammer; Amanda Kussrow; Robert A. Flowers II; Jens Meiler, Proceedings of the National Academy of Sciences current issue, 2016

Interaction/reaction assays have led to significant scientific discoveries in the biochemical, medical, and chemical disciplines. Several fundamental driving forces form the basis of intermolecular and intramolecular interactions in chemical and biochemical systems (London dispersion, hydrogen ...

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Mesoscale texture of cement hydrates [Engineering]

23-Feb-2016 | Katerina Ioannidou; Konrad J. Krakowiak; Mathieu Bauchy; Christian G. Hoover; Enrico Masoero; Sidney Yip; Franz-Jose ..., Proceedings of the National Academy of Sciences current issue, 2016

Strength and other mechanical properties of cement and concrete rely upon the formation of calcium–silicate–hydrates (C–S–H) during cement hydration. Controlling structure and properties of the C–S–H phase is a challenge, due to the complexity of this hydration product and of the mechanisms that ...

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Correction for Krishna Kumar et al., Limitations of GCTA as a solution to the missing heritability problem [Correction]

09-Feb-2016 | Proceedings of the National Academy of Sciences current issue, 2016

GENETICS Correction for “Limitations of GCTA as a solution to the missing heritability problem” by Siddharth Krishna Kumar, Marcus W. Feldman, David H. Rehkopf, and Shripad Tuljapurkar, which appeared in issue 1, January 5, 2016, of Proc Natl Acad Sci USA (113:E61–E70; first published December ...

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One-pot system for synthesis, assembly, and display of functional single-span membrane proteins on oil-water interfaces [Applied Physical Sciences]

19-Jan-2016 | Peter J. Yunker; Haruichi Asahara; Kuo-Chan Hung; Corey Landry; Laura R. Arriaga; Ilke Akartuna; John Heyman; Shaoro ..., Proceedings of the National Academy of Sciences current issue, 2016

Single-span membrane proteins (ssMPs) represent approximately one-half of all membrane proteins and play important roles in cellular communications. However, like all membrane proteins, ssMPs are prone to misfolding and aggregation because of the hydrophobicity of transmembrane helices, making ...

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Samuel Frederick Edwards: Founder of modern polymer and soft matter theory [Retrospective]

05-Jan-2016 | Nigel Goldenfeld, Proceedings of the National Academy of Sciences current issue, 2016

This year marks the 50th anniversary of the seminal paper by Sam Edwards on the statistical mechanics of a single polymer chain in dilute solution, a paper that in one stroke founded the modern quantitative understanding of polymer matter, and vaulted soft condensed matter on to the stage of ...

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Limitations of GCTA as a solution to the missing heritability problem [Genetics]

05-Jan-2016 | Siddharth Krishna Kumar; Marcus W. Feldman; David H. Rehkopf; Shripad Tuljapurkar, Proceedings of the National Academy of Sciences current issue, 2016

Genome-wide association studies (GWASs) seek to understand the relationship between complex phenotype(s) (e.g., height) and up to millions of single-nucleotide polymorphisms (SNPs). Early analyses of GWASs are commonly believed to have “missed” much of the additive genetic variance estimated from ...

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Protein-like proton exchange in a synthetic host cavity [Chemistry]

15-Dec-2015 | William M. Hart-Cooper; Carmelo Sgarlata; Charles L. Perrin; F. Dean Toste; Robert G. Bergman; Kenneth N. Raymond, Proceedings of the National Academy of Sciences current issue, 2015

The mechanism of proton exchange in a metal–ligand enzyme active site mimic (compound 1) is described through amide hydrogen–deuterium exchange kinetics. The type and ratio of cationic guest to host in solution affect the rate of isotope exchange, suggesting that the rate of exchange is driven by ...

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