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Acanthamoeba spp. in Contact Lenses from Healthy Individuals from Madrid, Spain

22-Apr-2016 | Thiago dos Santos Gomes; Angela Magnet; Fernando Izquierdo; Lucianna Vaccaro; Fernando Redondo; Sara Bueno; Maria Lu ..., PLoS ONE, 2016

by Thiago dos Santos Gomes, Angela Magnet, Fernando Izquierdo, Lucianna Vaccaro, Fernando Redondo, Sara Bueno, Maria Luisa Sánchez, Santiago Angulo, Soledad Fenoy, Carolina Hurtado, Carmen del Aguila Purpose Acanthamoeba keratitis (AK) is a painful and potentially blinding corneal infection ...

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Conformational Heterogeneity of Cyclosporin A in Cyclophilin 18 Binding

15-Apr-2016 | Weilin Lin; Andres Quintero; Yixin Zhang, PLoS ONE, 2016

by Weilin Lin, Andres Quintero, Yixin Zhang The immunosuppressive drug cyclosporin A (CsA) binds to its receptor protein cyclophilin 18 (Cyp18) in two distinct kinetic phases, while the mechanism remains elusive. Stopped-flow measurements coupled with titration and competition experiments were ...

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Assessing Regional-Scale Impacts of Short Rotation Coppices on Ecosystem Services by Modeling Land-Use Decisions

15-Apr-2016 | Jule Schulze; Karin Frank; Joerg A. Priess; Markus A. Meyer, PLoS ONE, 2016

by Jule Schulze, Karin Frank, Joerg A. Priess, Markus A. Meyer Meeting the world’s growing energy demand through bioenergy production involves extensive land-use change which could have severe environmental and social impacts. Second generation bioenergy feedstocks offer a possible solution to ...

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Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering

26-Feb-2016 | Bo Zhang-Haagen et al., PLoS ONE, 2016

by Bo Zhang-Haagen, Ralf Biehl, Luitgard Nagel-Steger, Aurel Radulescu, Dieter Richter, Dieter Willbold Small proteins like amyloid beta (Aβ) monomers are related to neurodegenerative disorders by aggregation to insoluble fibrils. Small angle neutron scattering (SANS) is a nondestructive method ...

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A Practical Anodic and Cathodic Curve Intersection Model to Understand Multiple Corrosion Potentials of Fe-Based Glassy Alloys in OH - Contained Solutions

15-Jan-2016 | Y. J. Li et al., PLoS ONE, 2016

by Y. J. Li, Y. G. Wang, B. An, H. Xu, Y. Liu, L. C. Zhang, H. Y. Ma, W. M. Wang A practical anodic and cathodic curve intersection model, which consisted of an apparent anodic curve and an imaginary cathodic line, was proposed to explain multiple corrosion potentials occurred in ...

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Data-Driven Engineering of Social Dynamics: Pattern Matching and Profit Maximization

15-Jan-2016 | Huan-Kai Peng et al., PLoS ONE, 2016

by Huan-Kai Peng, Hao-Chih Lee, Jia-Yu Pan, Radu Marculescu In this paper, we define a new problem related to social media, namely, the data-driven engineering of social dynamics. More precisely, given a set of observations from the past, we aim at finding the best short-term intervention that ...

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Computational Intelligence and Wavelet Transform Based Metamodel for Efficient Generation of Not-Yet Simulated Waveforms

08-Jan-2016 | Gabriel Oltean et al., PLoS ONE, 2016

by Gabriel Oltean, Laura-Nicoleta Ivanciu The design and verification of complex electronic systems, especially the analog and mixed-signal ones, prove to be extremely time consuming tasks, if only circuit-level simulations are involved. A significant amount of time can be saved if a cost ...

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The Combination of X-Ray Crystallography and Cryo-Electron Microscopy Provides Insight into the Overall Architecture of the Dodecameric Rvb1/Rvb2 Complex

08-Jan-2016 | Noella Silva-Martin et al., PLoS ONE, 2016

by Noella Silva-Martin, María I. Daudén, Sebastian Glatt, Niklas A. Hoffmann, Panagiotis Kastritis, Peer Bork, Martin Beck, Christoph W. Müller The Rvb1/Rvb2 complex is an essential component of many cellular pathways. The Rvb1/Rvb2 complex forms a dodecameric assembly where six copies of each ...

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Coaxial Microincision Cataract Surgery versus Standard Coaxial Small-Incision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials

08-Jan-2016 | Xingchao Shentu et al., PLoS ONE, 2016

by Xingchao Shentu, Xin Zhang, Xiajing Tang, Xiaoning Yu Background We conducted this meta-analysis to compare the outcomes of coaxial microincision cataract surgery (C-MICS) and standard coaxial small incision cataract surgery (C-SICS). Methods The outcomes of randomized controlled trials ...

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Stability of Phase Relationships While Coordinating Arm Reaches with Whole Body Motion

31-Dec-2015 | Romy S. Bakker et al., PLoS ONE, 2015

by Romy S. Bakker, Luc P. J. Selen, W. Pieter Medendorp The human movement repertoire is characterized by the smooth coordination of several body parts, including arm movements and whole body motion. The neural control of this coordination is quite complex because the various body parts have ...

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