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Structure Determination and Biochemical Characterization of a Putative HNH Endonuclease from Geobacter metallireducens GS-15

06-09-2013 | Shuang-yong Xu et al., PLoS ONE, 2013

by Shuang-yong Xu, Alexandre P. Kuzin, Jayaraman Seetharaman, Alice Gutjahr, Siu-Hong Chan, Yang Chen, Rong Xiao, Thomas B. Acton, Gaetano T. Montelione, Liang Tong The crystal structure of a putative HNH endonuclease, Gmet_0936 protein from Geobacter metallireducens GS-15, has been determined ...


Does Raising Type 1 Error Rate Improve Power to Detect Interactions in Linear Regression Models? A Simulation Study

16-08-2013 | Casey P. Durand, PLoS ONE, 2013

by Casey P. Durand Introduction Statistical interactions are a common component of data analysis across a broad range of scientific disciplines. However, the statistical power to detect interactions is often undesirably low. One solution is to elevate the Type 1 error rate so that important ...


Dynamic Simulation and Metabolome Analysis of Long-Term Erythrocyte Storage in Adenine–Guanosine Solution

16-08-2013 | Taiko Nishino et al., PLoS ONE, 2013

by Taiko Nishino, Ayako Yachie-Kinoshita, Akiyoshi Hirayama, Tomoyoshi Soga, Makoto Suematsu, Masaru Tomita Although intraerythrocytic ATP and 2,3-bisphophoglycerate (2,3-BPG) are known as direct indicators of the viability of preserved red blood cells and the efficiency of post-transfusion ...


Antenatal Depression in Anuradhapura, Sri Lanka and the Factor Structure of the Sinhalese Version of Edinburgh Post Partum Depression Scale among Pregnant Women

26-07-2013 | Suneth Buddhika Agampodi et al., PLoS ONE, 2013

by Suneth Buddhika Agampodi, Thilini Chanchala Agampodi Background Mental health problems among women of reproductive age group contribute to 7% of Global Burden of Diseases of women of all ages. Purpose of this study was to determine the prevalence and correlates of antenatal depression among ...


The Path Integral Formulation of Climate Dynamics

28-06-2013 | Antonio Navarra et al., PLoS ONE, 2013

by Antonio Navarra, Joe Tribbia, Giovanni Conti The chaotic nature of the atmospheric dynamics has stimulated the applications of methods and ideas derived from statistical dynamics. For instance, ensemble systems are used to make weather predictions recently extensive, which are designed to ...


A Study on Factors Affecting the Degradation of Magnesium and a Magnesium-Yttrium Alloy for Biomedical Applications

14-06-2013 | Ian Johnson et al., PLoS ONE, 2013

by Ian Johnson, Huinan Liu Controlling degradation of magnesium or its alloys in physiological saline solutions is essential for their potential applications in clinically viable implants. Rapid degradation of magnesium-based materials reduces the mechanical properties of implants prematurely ...


Solution Structure and Peptide Binding of the PTB Domain from the AIDA1 Postsynaptic Signaling Scaffolding Protein

14-06-2013 | Ekaterina Smirnova et al., PLoS ONE, 2013

by Ekaterina Smirnova, Riya Shanbhag, Arwa Kurabi, Mehdi Mobli, Jamie J. Kwan, Logan W. Donaldson AIDA1 links persistent chemical signaling events occurring at the neuronal synapse with global changes in gene expression. Consistent with its role as a scaffolding protein, AIDA1 is composed of ...


Effects of Gastric Irrigation on Bacterial Counts before Endoscopic Submucosal Dissection: A Randomized Case Control Prospective Study

07-06-2013 | Hirohito Mori et al., PLoS ONE, 2013

by Hirohito Mori, Hideki Kobara, Kazi Rafiq, Noriko Nishiyama, Shintaro Fujihara, Makoto Oryu, Tsutomu Masaki Objective The antiseptic effect of gastric irrigation before endoscopic submucosal dissection (ESD) has not yet been reported. The aim of the randomized prospective study is to evaluate ...


High-Resolution, High-Throughput, Positive-Tone Patterning of Poly(ethylene glycol) by Helium Beam Exposure through Stencil Masks

24-05-2013 | Eliedonna E. Cacao et al., PLoS ONE, 2013

by Eliedonna E. Cacao, Azeem Nasrullah, Tim Sherlock, Steven Kemper, Katerina Kourentzi, Paul Ruchhoeft, Gila E. Stein, Richard C. Willson In this work, a collimated helium beam was used to activate a thiol-poly(ethylene glycol) (SH-PEG) monolayer on gold to selectively capture proteins in the ...


Intrinsic Properties of Larval Zebrafish Neurons in Ethanol

03-05-2013 | Hiromi Ikeda et al., PLoS ONE, 2013

by Hiromi Ikeda, Alison H. Delargy, Tohei Yokogawa, Jason M. Urban, Harold A. Burgess, Fumihito Ono The behavioral effects of ethanol have been studied in multiple animal models including zebrafish. Locomotion of zebrafish larvae is resistant to high concentrations of ethanol in bath solution. ...


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