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480,066 Newest Publications about the topic solution

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Metformin and respiratory chain complex I: the last piece of the puzzle?

01-11-2014 | Fontaine E, Biochemical Journal, 2014

Metformin is the most widely prescribed drug used to treat patients affected by Type2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to complex I ...

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NTBI unveiled by chelatable fluorescent beads

01-11-2014 | Sebastiani G; Pantopoulos K, Biochemical Journal, 2014

Non-transferrin-bound iron (NTBI) emerges in plasma of patients with systemic iron overload, but has also been documented in further pathological conditions. Quantification of NTBI can be useful for diagnosis and management of these disorders. However, currently available detection methods are ...

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Dual-view plane illumination microscopy for rapid and spatially isotropic imaging

01-11-2014 | Abhishek Kumar; Yicong Wu; Ryan Christensen; Panagiotis Chandris; William Gandler; Evan McCreedy; Alexandra Bokinsky ..., Nature Protocols, 2014

Nature Protocols 9, 2555 (2014). doi:10.1038/nprot.2014.172 Authors: Abhishek Kumar, Yicong Wu, Ryan Christensen, Panagiotis Chandris, William Gandler, Evan McCreedy, Alexandra Bokinsky, Daniel A Colón-Ramos, Zhirong Bao, Matthew McAuliffe, Gary Rondeau & Hari Shroff We ...

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An Efficient Continuous Flow Approach to Furnish Furan-Based Biaryls.

21-10-2014 | Christopher Gordon; Trieu Trinh; Lacey Hizartzidis; Andrew Lin; Adam McCluskey; David Harman, Organic & Biomolecular Chemistry, 2014

Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)4N+F- and the immobilised t-butyl based palladium catalyst CatCart™ FC1032™. Deactivated aryl bromides and activated aryl ...

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Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces

21-10-2014 | Shintaro Takata; Yoshihiro Miura; Yuji Matsumoto, Physical Chemistry Chemical Physics, 2014

Using an ultra-high vacuum (UHV) electrochemistry approach with pulsed laser deposition (PLD), we investigated the band-gap state for TiO2(110). In the PLD chamber, a TiO2(110) surface was cleaned by annealing in O2 enough for it to exhibit a sharp (1 × 1) reflection high energy electron ...

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o-Benzyne fragmentation and isomerization pathways: a CASPT2 study

21-10-2014 | Giovanni Ghigo; Andrea Maranzana; Glauco Tonachini, Physical Chemistry Chemical Physics, 2014

The mechanisms of the fragmentation and isomerization pathways of o-benzyne were studied at the multi-configurational second-order perturbative level [CAS(12,12)-PT2]. The direct fragmentation of o-benzyne to C2H2 + C4H2 follows two mechanisms: a concerted mechanism and a stepwise mechanism. ...

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Importance of D-glycopyranoside structure to the bioactivity and target affinity of jasmonic acid glucoside

21-10-2014 | Minoru Ueda; Gangqiang Yang; Yuuki Nukadzuka; Yasuhiro Ishimaru; Satoru Tamura; Yoshiyuki Manabe, Organic & Biomolecular Chemistry, 2014

12-O-β-D-Glucopyranosyljasmonic acid (JAG) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of 1 revealed the unique role of its glycone moiety. Biological activity and target affinity of JAG were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique ...

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One-Step Polymer Screen-Printing for Microfluidic Paper-Based Analytical Device ([small mu ]PAD) Fabrication

21-10-2014 | Yupaporn Sameenoi; Piyaporn Na Nongkai; Souksanh Nouanthavong; Charles Henry; Duangjai Nacapricha, Analyst, 2014

We report the simple, low-cost, one-step fabrication method for microfluidic paper-based analytical devices (μPAD) using only polystyrene and a patterned screen. The polystyrene solution applied through the screen penetrates through the paper forming a three dimensional hydrophobic barrier, ...

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Asymmetric organocatalytic SOMO reactions of enol silanes and silyl ketene (thio)acetals

21-10-2014 | Pavol Tisovský; Mária Mečiarová; Radovan Šebesta, Organic & Biomolecular Chemistry, 2014

Organocatalytic SOMO reactions can provide access to various α-functionalized carbonyl compounds. Chiral imidazolidinones catalysed the organo-SOMO reactions of aldehydes and ketones with cyclic and acyclic enol silanes. The resulting chiral dicarbonyl compounds were obtained in yields of up to ...

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Solution structure of a cucurbit[8]uril induced compact supramolecular protein dimer

21-10-2014 | Dang Dang; Ralph Bosmans; Christian Moitzi; Ilja Karina Voets; Luc Brunsveld, Organic & Biomolecular Chemistry, 2014

Supramolecular assembly of a beta-barrel protein via cucurbit[8]uril results in compact z-shaped protein dimers. SAXS data reveal the formation of a well ordered protein dimer, notwithstanding being connected by a reversible and flexible peptide linker, and highlight the supramolecular induced ...

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