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3,847 Newest Publications about the topic viruses


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3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H

17-Jun-2016 | Bulan Wu; Jing Tang; Daniel J. Wilson; Andrew D. Huber; Mary C. Casey; Juan Ji; Jayakanth Kankanala; Jiashu Xie; Ste ..., Journal of Medicinal Chemistry, 2016

Resistance selection by human immunodeficiency virus (HIV) toward known drug regimens necessitates the discovery of structurally novel antivirals with a distinct resistance profile. On the basis of our previously reported 3-hydroxypyrimidine-2,4-dione (HPD) core, we have designed and synthesized ...


Label‐free Electrochemical Impedance Detection of Rotavirus Based on Immobilized Antibodies on Gold Sononanoparticles

15-Jun-2016 | Aisha Attar, Jihane Mandli, My Mustapha Ennaji, Aziz Amine, Electroanalysis, 2016

Abstract Currently, rotaviruses (RVs) are the leading cause of severe childhood gastroenteritis worldwide. This study proposes a sensitive and simple label‐free assay for determining rotaviruses using, for the first time, electrochemical impedance spectroscopy (EIS). The immunosensor is ...


Optimization of the immobilization of bacterial spores on glass substrates with organosilanes (Phys. Status Solidi A 6∕2016)

14-Jun-2016 | Julio Arreola, Malte Mätzkow, Marlena Palomar Durán, Anton Greeff, Michael Keusgen, Michael J. Schöning, physica status solidi (a), 2016

Bacterial spores are suitable for use as detectors to recognize microorganisms (e.g., bacteria, viruses) or evaluate aseptic processing due to their ability to sense environmental changes and survive prolonged harsh conditions (e.g., high temperature, extreme pH levels). In their publication on ...


The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1{gamma} sumoylation and poly-SUMO chain elongation [Microbiology]

14-Jun-2016 | Sook-Young Sohn; Patrick Hearing, Proceedings of the National Academy of Sciences current issue, 2016

The adenovirus (Ad) early region 4 (E4)-ORF3 protein regulates diverse cellular processes to optimize the host environment for the establishment of Ad replication. E4-ORF3 self-assembles into multimers to form a nuclear scaffold in infected cells and creates distinct binding interfaces for ...


Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques [Medical Sciences]

14-Jun-2016 | Hui Li; Shuyi Wang; Rui Kong; Wenge Ding; Fang-Hua Lee; Zahra Parker; Eunlim Kim; Gerald H. Learn; Paul Hahn; Ben Po ..., Proceedings of the National Academy of Sciences current issue, 2016

Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting ...


IJMS, Vol. 17, Pages 931: Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response

14-Jun-2016 | Liu, Ming-Kun ; Lin, Jhe-Jhih ; Chen, Chung-Yung ; Kuo, Szu-Cheng ; Wang, Yu-Ming ; Chan, Hong-Lin ; Wu, Tzong Yuan, International Journal of Molecular Sciences, 2016

BacMam is an insect-derived recombinant baculovirus that can deliver genes into mammalian cells. BacMam vectors carrying target genes are able to enter a variety of cell lines by endocytosis, but the level of expression of the transgene depends on the cell line and the state of the transduced ...


IJMS, Vol. 17, Pages 922: Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels

13-Jun-2016 | Grammatikos, Georgios ; Dietz, Julia ; Ferreiros, Nerea ; Koch, Alexander ; Dultz, Georg ; Bon, Dimitra ; Karakasili ..., International Journal of Molecular Sciences, 2016

Hepatitis C virus (HCV) substantially affects lipid metabolism, and remodeling of sphingolipids appears to be essential for HCV persistence in vitro. The aim of the current study is the evaluation of serum sphingolipid variations during acute HCV infection. We enrolled prospectively 60 ...


Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives

12-Jun-2016 | Author(s): Subhash Chander, Ping Wang, Penta Ashok, Liu-Meng Yang, Yong-Tang Zheng, Sankaranarayanan Mur ..., Bioorganic Chemistry, 2016

Publication date: August 2016 Source:Bioorganic Chemistry, Volume 67 Author(s): Subhash Chander, Ping Wang, Penta Ashok, Liu-Meng Yang, Yong-Tang Zheng, Sankaranarayanan Murugesan In the present study, fifteen novel ...


Molecules, Vol. 21, Pages 766: Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

11-Jun-2016 | Yamamoto, Junpei ; Takahata, Chiaki ; Kuraoka, Isao ; Hirota, Kouji ; Iwai, Shigenori, Molecules, 2016

Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However, they are also considered to be DNA ...


Long‐term microbiota and virome in a Zürich patient after fecal transplantation against Clostridium difficile infection

11-Jun-2016 | Felix Broecker, Jochen Klumpp, Karin Moelling, Annals of the New York Academy of Sciences, 2016

Fecal microbiota transplantation (FMT) is an emerging therapeutic option for Clostridium difficile infections that are refractory to conventional treatment. FMT introduces fecal microbes into the patient's intestine that prevent the recurrence of C. difficile, leading to rapid expansion of ...


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