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3,128 Newest Publications about the topic viruses

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HIV-1 antiviral behavior of anionic PPI metallo-dendrimers with EDA core

25-May-2015 | Author(s): Sandra García-Gallego , Laura Díaz , José Luis Jiménez , Rafael Gómez , F. Javier de la Mata , M. Án ..., European Journal of Medicinal Chemistry, 2015

Publication date: 15 June 2015 Source:European Journal of Medicinal Chemistry, Volume 98 Author(s): Sandra García-Gallego , Laura Díaz , José Luis Jiménez , Rafael Gómez , F. Javier de la Mata , M. Ángeles Muñoz-Fernández The development of novel strategies to prevent HIV-1 infection ...

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Diverse models for anti-HIV activity of purine nucleoside analogs

23-May-2015 | Khatri, Naveen; Lather, Viney; Madan, A K, Chemistry Central Journal , 2015

Background: Purine nucleoside analogs (PNAs) constitute an important group of cytotoxic drugs for the treatment of neoplastic and autoimmune diseases. In the present study, classification models have been developed for the prediction of the anti-HIV activity of purine nucleoside ...

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Finger Prick Dried Blood Spots for HIV Viral Load Measurement in Field Conditions in Zimbabwe

22-May-2015 | Sue Napierala Mavedzenge et al., PLoS ONE, 2015

by Sue Napierala Mavedzenge, Calum Davey, Tarisai Chirenje, Phyllis Mushati, Sibongile Mtetwa, Jeffrey Dirawo, Boniface Mudenge, Andrew Phillips, Frances M. Cowan Background In the context of a community-randomized trial of antiretrovirals for HIV prevention and treatment among sex workers in ...

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[Report] Structure of the HIV-1 RNA packaging signal

22-May-2015 | Sarah C. Keane; Xiao Heng; Kun Lu; Siarhei Kharytonchyk; Venkateswaran Ramakrishnan; Gregory Carter; Shawn Barton; A ..., Science , 2015

The 5′ leader of the HIV-1 genome contains conserved elements that direct selective packaging of the unspliced, dimeric viral RNA into assembling particles. By using a 2H-edited nuclear magnetic resonance (NMR) approach, we determined the structure of a 155-nucleotide region of the leader that is ...

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[Special Issue Research Article] Structure and function of the global ocean microbiome

22-May-2015 | Shinichi Sunagawa; Luis Pedro Coelho; Samuel Chaffron; Jens Roat Kultima; Karine Labadie; Guillem Salazar; Bardya Dj ..., Science , 2015

Microbes are dominant drivers of biogeochemical processes, yet drawing a global picture of functional diversity, microbial community structure, and their ecological determinants remains a grand challenge. We analyzed 7.2 terabases of metagenomic data from 243 Tara Oceans samples from 68 locations ...

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[Special Issue Research Article] Patterns and ecological drivers of ocean viral communities

22-May-2015 | Jennifer R. Brum; J. Cesar Ignacio-Espinoza; Simon Roux; Guilhem Doulcier; Silvia G. Acinas; Adriana Alberti; Samuel ..., Science , 2015

Viruses influence ecosystems by modulating microbial population size, diversity, metabolic outputs, and gene flow. Here, we use quantitative double-stranded DNA (dsDNA) viral-fraction metagenomes (viromes) and whole viral community morphological data sets from 43 Tara Oceans expedition samples to ...

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[Special Issue Research Article] Determinants of community structure in the global plankton interactome

22-May-2015 | Gipsi Lima-Mendez; Karoline Faust; Nicolas Henry; Johan Decelle; Sébastien Colin; Fabrizio Carcillo; Samuel Chaffron ..., Science , 2015

Species interaction networks are shaped by abiotic and biotic factors. Here, as part of the Tara Oceans project, we studied the photic zone interactome using environmental factors and organismal abundance profiles and found that environmental factors are incomplete predictors of community ...

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[Perspective] Uncovering hidden worlds of ocean biodiversity

22-May-2015 | E. Virginia Armbrust; Stephen R. Palumbi, Science , 2015

A bewildering swirl of tiny creatures dominates life in the oceans. More numerous than the stars in the universe, these organisms serve as the foundation of all marine food webs, recycling major elements and producing and consuming about half the organic matter generated on Earth each year (1). ...

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[This Week in Science] Structural signals that direct HIV packaging

22-May-2015 | Valda Vinson, Science , 2015

Author: Valda Vinson

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[In Depth] Canadian registry to track thousands of pot smokers

22-May-2015 | Lizzie Wade, Science , 2015

Fifteen years after learning about the medical benefits of cannabis from patients in a sickle cell clinic in Kingston, Mark Ware is studying the drug on a grand scale. A pain management researcher at McGill University Health Centre in Montreal, Canada, he directs the Quebec Cannabis Registry, a ...

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