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4,453 Newest Publications about the topic viruses

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Molecules, Vol. 22, Pages 1337: A Review of the Antiviral Role of Green Tea Catechins

12-Aug-2017 | Xu, Jun ; Xu, Zhao ; Zheng, Wenming, Molecules, 2017

Molecules, Vol. 22, Pages 1337: A Review of the Antiviral Role of Green Tea Catechins Molecules doi: 10.3390/molecules22081337 Authors: Jun Xu Zhao Xu Wenming Zheng Over the centuries, infectious diseases caused by viruses have seriously threatened human health globally. Viruses ...

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Expression optimization of a cell membrane-penetrating human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana

11-Aug-2017 | Romana J. R. Yanez; Renate Lamprecht; Milaid Granadillo; Brandon Weber; Isis Torrens; Edward P. Rybicki; Inga I. Hit ..., PLoS ONE, 2017

by Romana J. R. Yanez, Renate Lamprecht, Milaid Granadillo, Brandon Weber, Isis Torrens, Edward P. Rybicki, Inga I. Hitzeroth High-risk human papillomaviruses (hr-HPVs) cause cervical cancer, the fourth most common cancer in women worldwide. A HPV-16 candidate therapeutic vaccine, LALF32-51-E7, ...

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Intracellular signaling in CRISPR-Cas defense

11-Aug-2017 | Gil Amitai; Rotem Sorek, Science , 2017

The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated protein) system is known to protect bacteria against foreign invading DNA, usually from phages (viruses that infect bacteria) or plasmids (circular DNA found in the cytoplasm of bacteria). Since the first ...

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Effective Conformational Sampling in Explicit Solvent with Gaussian Biased Accelerated Molecular Dynamics

11-Aug-2017 | Qiang Shao; Weiliang Zhu, Journal of Chemical Theory and Computation, 2017

In this Article, a user-friendly Gaussian biased accelerated molecular dynamics (GbAMD) method is presented that uses a sum of Gaussians of potential energies as the biased force to accelerate the conformational sampling. The easy parameter setting of GbAMD is demonstrated in a variety of ...

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Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

10-Aug-2017 | Xue Zhi Zhao; Steven J. Smith; Daniel P. Maskell; Mathieu Métifiot; Valerie E. Pye; Katherine Fesen; Christophe Marc ..., Journal of Medicinal Chemistry, 2017

Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG). The second-generation agent, dolutegravir (DTG), has enjoyed considerable clinical success; however, resistance-causing ...

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Molecules, Vol. 22, Pages 1319: Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris

09-Aug-2017 | Gong, Kai-Kai ; Li, Ping-Lin ; Qiao, Dan ; Zhang, Xing-Wang ; Chu, Mei-Jun ; Qin, Guo-Fei ; Tang, Xu-Li ; Li, Guo-Qiang, Molecules, 2017

Molecules, Vol. 22, Pages 1319: Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris Molecules doi: 10.3390/molecules22081319 Authors: Kai-Kai Gong Ping-Lin Li Dan Qiao Xing-Wang Zhang Mei-Jun Chu Guo-Fei Qin Xu-Li Tang Guo-Qiang Li A ...

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Mapping the interactome of HPV E6 and E7 oncoproteins with the Ubiquitin‐Proteasome System

08-Aug-2017 | Juline Poirson, Elise Biquand, Marie‐ Laure Straub, Patricia Cassonnet, Yves Nominé, Louis Jones, Sylvie der Werf, G ..., FEBS Journal, 2017

Abstract Protein ubiquitination and its reverse reaction, deubiquitination, regulate protein stability, protein binding activity and their subcellular localization. These reactions are catalyzed by the enzymes E1, E2 and E3 Ubiquitin ligases and deubiquitinases. The ubiquitin‐proteasome system ...

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Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies [Immunology and Inflammation]

08-Aug-2017 | Joyce K. Hwang; Chong Wang; Zhou Du; Robin M. Meyers; Thomas B. Kepler; Donna Neuberg; Peter D. Kwong; John R. Masco ..., Proceedings of the National Academy of Sciences current issue, 2017

Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally from V, D, J gene segments. Each variable region contains three antigen-contacting complementarity-determining ...

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Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association [Biochemistry]

08-Aug-2017 | Wenting Zhang; Wenjie Zheng; Yukimatsu Toh; Miguel A. Betancourt-Solis; Jiagang Tu; Yanlin Fan; Vikram N. Vakharia; ..., Proceedings of the National Academy of Sciences current issue, 2017

Many enveloped viruses encode a matrix protein. In the influenza A virus, the matrix protein M1 polymerizes into a rigid protein layer underneath the viral envelope to help enforce the shape and structural integrity of intact viruses. The influenza virus M1 is also known to mediate virus budding ...

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IJERPH, Vol. 14, Pages 892: Spatio-Temporal Distribution of Vector-Host Contact (VHC) Ratios and Ecological Niche Modeling of the West Nile Virus Mosquito Vector, Culex quinquefasciatus, in the City of New Orleans, LA, USA

08-Aug-2017 | Sallam, Mohamed F.; Michaels, Sarah R.; Riegel, Claudia ; Pereira, Roberto M.; Zipperer, Wayne ; Lockaby, B. Graeme; ..., International Journal of Environmental Research and Public Health, 2017

IJERPH, Vol. 14, Pages 892: Spatio-Temporal Distribution of Vector-Host Contact (VHC) Ratios and Ecological Niche Modeling of the West Nile Virus Mosquito Vector, Culex quinquefasciatus, in the City of New Orleans, LA, USA International Journal of Environmental Research and Public Health doi: ...

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