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4,495 Newest Publications about the topic viruses

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The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring

13-Sep-2017 | Keisuke Kamba; Takashi Nagata; Masato Katahira, Physical Chemistry Chemical Physics, 2017

APOBEC3G (A3G), an anti-human immunodeficiency virus 1 factor, deaminates cytidines. We examined deamination of two cytidines located separately on substrate ssDNA by the C-terminal domain (CTD) of A3G using real-time NMR monitoring. The deamination preference between the two cytidines was lost ...

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TAT-mediated transduction of bacterial redox proteins generates a cytoprotective effect on neuronal cells

08-Sep-2017 | Cecilia L. Balaban; Claudia Banchio; Eduardo A. Ceccarelli, PLoS ONE, 2017

by Cecilia L. Balaban, Claudia Banchio, Eduardo A. Ceccarelli Cell penetrating peptides, also known as protein transduction domains, have the capacity to ubiquitously cross cellular membranes carrying many different cargos with negligible cytotoxicity. As a result, they have emerged as a ...

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Health care utilization in general practice after HPV vaccination—A Danish nationwide register-based cohort study

08-Sep-2017 | Lene Wulff Krogsgaard; Claus Høstrup Vestergaard; Oleguer Plana-Ripoll; Tina Hovgaard Lützen; Mogens Vestergaard; Mo ..., PLoS ONE, 2017

by Lene Wulff Krogsgaard, Claus Høstrup Vestergaard, Oleguer Plana-Ripoll, Tina Hovgaard Lützen, Mogens Vestergaard, Morten Fenger-Grøn, Bodil Hammer Bech, Dorte Rytter Objective The Human Papillomavirus (HPV) vaccine has increasingly been suspected of adverse effects in Denmark since 2013. By ...

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Prevalence of self-reported comorbidities in HIV positive and HIV negative men who have sex with men over 55 years—The Australian Positive & Peers Longevity Evaluation Study (APPLES)

08-Sep-2017 | Kathy Petoumenos; Robin Huang; Jennifer Hoy; Mark Bloch; David J. Templeton; David Baker; Michelle Giles; Matthew G. ..., PLoS ONE, 2017

by Kathy Petoumenos, Robin Huang, Jennifer Hoy, Mark Bloch, David J. Templeton, David Baker, Michelle Giles, Matthew G. Law, David A. Cooper In Australia, almost half of HIV-positive people are now aged over 50 and are predominately gay and bisexual men (GBM). Compared to the general ...

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Resistance of Echovirus 11 to ClO2 Is Associated with Enhanced Host Receptor Use, Altered Entry Routes, and High Fitness

08-Sep-2017 | Qingxia Zhong; Anna Carratalà; Hyunjin Shim; Virginie Bachmann; Jeffrey D. Jensen; Tamar Kohn, Environmental Science & Technology, 2017

Waterborne viruses can exhibit resistance to common water disinfectants, yet the mechanisms that allow them to tolerate disinfection are poorly understood. Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental evolution, and we assessed the associated ...

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Molecules, Vol. 22, Pages 1498: Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae

08-Sep-2017 | Chen, Huan ; Zhang, Rong ; Luo, Rong-Hua ; Yang, Liu-Meng ; Wang, Rui-Rui ; Hao, Xiao-Jiang ; Zheng, Yong-Tang, Molecules, 2017

Molecules, Vol. 22, Pages 1498: Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae Molecules doi: 10.3390/molecules22091498 Authors: Huan Chen Rong Zhang Rong-Hua Luo Liu-Meng Yang Rui-Rui Wang Xiao-Jiang ...

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IJMS, Vol. 18, Pages 1929: Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral

08-Sep-2017 | Hu, Yanmei ; Zhang, Jiantao ; Musharrafieh, Rami ; Hau, Raymond ; Ma, Chunlong ; Wang, Jun, International Journal of Molecular Sciences, 2017

IJMS, Vol. 18, Pages 1929: Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral International Journal of Molecular Sciences doi: 10.3390/ijms18091929 Authors: Yanmei Hu Jiantao Zhang Rami ...

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Multiscale Simulation of Receptor–Drug Association Kinetics: Application to Neuraminidase Inhibitors

06-Sep-2017 | Fabian Zeller; Manuel P. Luitz; Rainer Bomblies; Martin Zacharias, Journal of Chemical Theory and Computation, 2017

A detailed understanding of the drug–receptor association process is of fundamental importance for drug design. Due to the long time scales of typical binding kinetics, the atomistic simulation of the ligand traveling from bulk solution into the binding site is still computationally challenging. ...

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Polymeric mannosides prevent DC-SIGN-mediated cell-infection by cytomegalovirus

05-Sep-2017 | sami brument; coraline Cheneau; Yoan brissonnet; David Deniaud; Franck Halary; Sébastien G Gouin, Organic & Biomolecular Chemistry, 2017

Human cytomegalovirus (CMV) is a beta-herpesvirus with a high prevalence in the population. CMV is asymptomatic for immunocompetent adults but is a leading cause of morbidity for new born and immunocompromised patients. It was recently shown that the envelope glycoprotein B (gB) of HCMV interacts ...

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Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography [Pharmacology]

05-Sep-2017 | Albert H. Chan; Won-Gil Lee; Krasimir A. Spasov; José A. Cisneros; Shalley N. Kudalkar; Zaritza O. Petrova; Amanda B ..., Proceedings of the National Academy of Sciences current issue, 2017

Development of resistance remains a major challenge for drugs to treat HIV-1 infections, including those targeting the essential viral polymerase, HIV-1 reverse transcriptase (RT). Resistance associated with the Tyr181Cys mutation in HIV-1 RT has been a key roadblock in the discovery of ...

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