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2,919 Newest Publications about the topic viruses


[Report] Structure and inhibition of EV-D68, a virus that causes respiratory illness in children

02-Jan-2015 | Yue Liu; Ju Sheng; Andrei Fokine; Geng Meng; Woong-Hee Shin; Feng Long; Richard J. Kuhn; Daisuke Kihara; Michael G. ..., Science , 2015

A virus that causes respiratory illness in children can be inhibited by an anti-rhinovirus drug. Authors: Yue Liu, Ju Sheng, Andrei Fokine, Geng Meng, Woong-Hee Shin, Feng Long, Richard J. Kuhn, Daisuke Kihara, Michael G. Rossmann


Identification of an Unclassified Paramyxovirus in Coleura afra: A Potential Case of Host Specificity

31-Dec-2014 | Gael D. Maganga et al., PLoS ONE, 2014

by Gael D. Maganga, Mathieu Bourgarel, Judicael Obame Nkoghe, Nadine N'Dilimabaka, Christian Drosten, Christophe Paupy, Serge Morand, Jan Felix Drexler, Eric M. Leroy Bats are known to harbor multiple paramyxoviruses. Despite the creation of two new genera, Aquaparamyxovirus and Ferlavirus, to ...


Ammonia as an In Situ Sanitizer: Inactivation Kinetics and Mechanisms of the ssRNA Virus MS2 by NH3

31-Dec-2014 | Loïc Decrey; Shinobu Kazama; Kai M. Udert; Tamar Kohn, Environmental Science & Technology, 2014

Sanitizing human and animal waste (e.g., urine, fecal sludge, or grey water) is a critical step in reducing the spread of disease and ensuring microbially safe reuse of waste materials. Viruses are particularly persistent pathogens and can be transmitted through inadequately sanitized waste. ...


Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

30-Dec-2014 | Sanjeev Kumar V. Vernekar; Zheng Liu; Eva Nagy; Lena Miller; Karen A. Kirby; Daniel J. Wilson; Jayakanth Kankanala; ..., Journal of Medicinal Chemistry, 2014

Reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not targeted by current chemotherapy against human immunodeficiency virus (HIV). Although numerous chemotypes have been reported to inhibit HIV RNase H biochemically, few show ...


Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure [Biochemistry]

30-Dec-2014 | James M. Kovacs; Erik Noeldeke; Heather Jiwon Ha; Hanqin Peng; Sophia Rits-Volloch; Stephen C. Harrison; Bing Chen, Proceedings of the National Academy of Sciences current issue, 2014

The HIV-1 envelope spike [trimeric (gp160)3, cleaved to (gp120/gp41)3] is the mediator of viral entry and the principal target of humoral immune response to the virus. Production of a recombinant preparation that represents the functional spike poses a challenge for vaccine development, because ...


Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30-Dec-2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...


Thermotropic liquid crystals from biomacromolecules [Physics]

30-Dec-2014 | Kai Liu; Dong Chen; Alessio Marcozzi; Lifei Zheng; Juanjuan Su; Diego Pesce; Wojciech Zajaczkowski; Anke Kolbe; Wojc ..., Proceedings of the National Academy of Sciences current issue, 2014

Complexation of biomacromolecules (e.g., nucleic acids, proteins, or viruses) with surfactants containing flexible alkyl tails, followed by dehydration, is shown to be a simple generic method for the production of thermotropic liquid crystals. The anhydrous smectic phases that result exhibit ...


Estrogen-related receptor {alpha} is required for efficient human cytomegalovirus replication [Microbiology]

30-Dec-2014 | Jesse Hwang; John G. Purdy; Kai Wu; Joshua D. Rabinowitz; Thomas Shenk, Proceedings of the National Academy of Sciences current issue, 2014

An shRNA-mediated screen of the 48 human nuclear receptor genes identified multiple candidates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, including the estrogen-related receptor α (ERRα), an orphan nuclear receptor. The 50-kDa receptor and a 76-kDa ...


Biochemical investigations of human papillomavirus‐infected cervical fluids

29-Dec-2014 | Samjin Choi, Hun‐Kuk Park, Gyeong Eun Min, Yeon‐Hee Kim, Microscopy Research and Technique, 2014

ABSTRACT Purpose: Cervical cancer is caused by persistent infection with high‐risk types of human papillomavirus (HPV). The aim of this study was to investigate the potential of Raman spectroscopy as a stand‐alone analytical tool for clinical diagnosis of HPV infection using human cervical ...


Barcoded Microchips for Biomolecular Assays

29-Dec-2014 | Yi Zhang; Jiashu Sun; Yu Zou; Wenwen Chen; Wei Zhang; Jianzhong Jeff Xi; Xingyu Jiang, Analytical Chemistry, 2014

Multiplexed assay of analytes is of great importance for clinical diagnostics and other analytical applications. Barcode-based bioassays with the ability to encode and decode may realize this goal in a straightforward and consistent manner. We present here a microfluidic barcoded chip containing ...


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