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3,310 Newest Publications about the topic viruses

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In vitro assembly of a viral envelope

27-Aug-2015 | Penny Miles; Peter Cassidy; Lynn Donlon; Orr Yarkoni; Daniel Frankel, Soft Matter, 2015

Viruses such as influenza and Ebola are enveloped in lipid bilayers annexed from host cells and containing glycoproteins essential for the infection process. At the molecular level little is known about the assembly process in terms of physical interactions between the lipids and glycoproteins. ...

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Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of l-ascorbic or imino-l-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations

23-Aug-2015 | Author(s): Maja Stipković Babić, Damjan Makuc, Janez Plavec, Tamara Martinović, Sandra Kraljević Pavelić, ..., European Journal of Medicinal Chemistry, 2015

Publication date: 18 September 2015 Source:European Journal of Medicinal Chemistry, Volume 102 Author(s): Maja Stipković Babić, Damjan Makuc, Janez Plavec, Tamara Martinović, Sandra Kraljević Pavelić, Krešimir Pavelić, Robert Snoeck, Graciela Andrei, Dominique Schols, ...

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Synthesis and antiviral activity of some new bis-1,3-thiazole derivatives

23-Aug-2015 | Author(s): Kamal M. Dawood, Taha M.A. Eldebss, Heba S.A. El-Zahabi, Mahmoud H. Yousef, European Journal of Medicinal Chemistry, 2015

Publication date: 18 September 2015 Source:European Journal of Medicinal Chemistry, Volume 102 Author(s): Kamal M. Dawood, Taha M.A. Eldebss, Heba S.A. El-Zahabi, Mahmoud H. Yousef Treatment of 3-phenyl-1,3-thiazolidin-4-one derivative 1 with phenylisothiocyanate in DMF, in the ...

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Towards a Science of Community Stakeholder Engagement in Biomedical HIV Prevention Trials: An Embedded Four-Country Case Study

21-Aug-2015 | Peter A. Newman et al., PLoS ONE, 2015

by Peter A. Newman, Clara Rubincam, Catherine Slack, Zaynab Essack, Venkatesan Chakrapani, Deng-Min Chuang, Suchon Tepjan, Murali Shunmugam, Surachet Roungprakhon, Carmen Logie, Jennifer Koen, Graham Lindegger Objectives Broad international guidelines and studies in the context of individual ...

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Self-Assembly of an Alphavirus Core-like Particle Is Distinguished by Strong Intersubunit Association Energy and Structural Defects

21-Aug-2015 | Joseph Che-Yen Wang; Chao Chen; Vamseedhar Rayaprolu; Suchetana Mukhopadhyay; Adam Zlotnick, ACS Nano, 2015

Weak association energy can lead to uniform nanostructures: defects can anneal due to subunit lability. What happens when strong association energy leads to particles where defects are trapped? Alphaviruses are enveloped viruses whose icosahedral nucleocapsid core can assemble independently. We ...

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Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease

21-Aug-2015 | John M. Louis; Lalit Deshmukh; Jane M. Sayer; Annie Aniana; G. Marius Clore, Biochemistry, 2015

N-Terminal self-cleavage (autoprocessing) of the HIV-1 protease precursor is crucial for liberating the active dimer. Under drug pressure, evolving mutations are predicted to modulate autoprocessing, and the reduced catalytic activity of the mature protease (PR) is likely compensated by enhanced ...

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Iron Oxide Based Nanoparticles for Magnetic Hyperthermia Strategies in Biological Applications

20-Aug-2015 | Yolanda Piñeiro, Zulema Vargas, José Rivas, Manuel Arturo López‐Quintela, European Journal of Inorganic Chemistry, 2015

Abstract The use of multifunctional nanoparticles (NPs), usually in the range of 3–100 nm, with their newly discovered properties – such as superparamagnetic (SPM) behaviour, enhancement of activity and selectivity in catalytic processes and localised surface plasmon resonance (LSPR) – offers ...

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IJMS, Vol. 16, Pages 19780-19795: Endoplasmic Reticulum Stress Cooperates in Zearalenone-Induced Cell Death of RAW 264.7 Macrophages

20-Aug-2015 | Chen, Fenglei ; Li, Qian ; Zhang, Zhe ; Lin, Pengfei ; Lei, Lanjie ; Wang, Aihua ; Jin, Yaping, International Journal of Molecular Sciences, 2015

Zearalenone (ZEA) is a fungal mycotoxin that causes cell apoptosis and necrosis. However, little is known about the molecular mechanisms of ZEA toxicity. The objective of this study was to explore the effects of ZEA on the proliferation and apoptosis of RAW 264.7 macrophages and to uncover the ...

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Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep Process

19-Aug-2015 | Alvaro Mallagaray, Julia Lockhauserbäumer, Grant Hansman, Charlotte Uetrecht, Thomas Peters, Angewandte Chemie International Edition, 2015

Abstract Human noroviruses recognize histo blood group antigens (HBGAs) as cellular attachment factors. Recently, it has been discovered that norovirus infection can be significantly enhanced by HBGA binding. Yet the attachment process and how it promotes host‐cell entry is only poorly ...

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A T7exonuclease‐assisted target recycling amplification with graphene oxide acting as the signal amplifier for fluorescence polarization detection of human immunodeficiency virus (HIV) DNA

19-Aug-2015 | Lijun Wang, Jianniao Tian, Wen Yang, Yanchun Zhao, Shulin Zhao, Luminescence, 2015

Abstract We report a fluorescence polarization (FP) platform for human immunodeficiency virus (HIV) DNA detection based on T7exonuclease‐assisted target recycling amplification with graphene oxide (GO) acting as a FP signal amplifier. In the sensing method, the presence of the target DNA leads ...

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