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3,367 Newest Publications about the topic viruses


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Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues

01-Oct-2015 | Cheng-Hsun Wu; Yi-Ping Chen; Shing-Lung Liu; Fan-Ching Chien; Chung-Yuan Mou; Richard P. Cheng, Organic & Biomolecular Chemistry, 2015

RNA is a drug target involved in diverse cellular functions and viral processes. Molecules that inhibit the HIV TAR RNA–Tat protein interaction may attenuate Tat/TAR-dependent protein expression and potentially serve as anti-HIV therapeutics. By incorporating positively charged residues with ...


Structure-Function Relationships of Antimicrobial Peptides and Proteins with Respect to Contact Molecules on Pathogen Surfaces

30-Sep-2015 | Zhang, Ruiyan; Eckert, Thomas; Lutteke, Thomas; Hanstein, Stefan; Scheidig, Axel; M. J. J. Bonvin, Alexandre; E. Nif ..., Current Topics in Medicinal Chemistry, 2015

Abstract: The Antimicrobial peptides (e.g. defensins, hevein-like molecules and food-protecting peptides like nisin) are able to interact specifically with contact structures on pathogen surfaces. Besides protein receptors, important recognition points for such contacts are provided by ...


Mammalian Antimicrobial Peptides: Promising Therapeutic Targets Against Infection and Chronic Inflammation

30-Sep-2015 | Dutta, Pujarini; Das, Santasabuj, Current Topics in Medicinal Chemistry, 2015

Abstract: Antimicrobial peptides (AMPs) are integral components of the host innate immune system and functional throughout the plant and animal kingdoms. AMPs are short cationic molecules and lethal against a wide range of bacteria, viruses, fungi, yeast and protozoa due to their ...


NMR Structures and Interactions of Antimicrobial Peptides with Lipopolysaccharide: Connecting Structures to Functions

30-Sep-2015 | Bhattacharjya, Surajit, Current Topics in Medicinal Chemistry, 2015

Abstract: Antimicrobial peptides (AMPs) establish the first line of host defense mechanism against invading microorganisms including bacteria, viruses, fungi and parasites. In recent years, emergence and spread of antibiotic resistance bacterial pathogens have dawn considerable interest in ...


Evaluation of Cervical Cancer Screening Programs in Côte d’Ivoire, Guyana, and Tanzania: Effect of HIV Status

25-Sep-2015 | Jean Anderson et al., PLoS ONE, 2015

by Jean Anderson, Megan Wysong, Deb Estep, Giulia Besana, Sharon Kibwana, John Varallo, Kai Sun, Enriquito Lu Background HIV infection increases a woman’s risk for cervical cancer, and cervical cancer incidence and mortality rates are higher in countries with high HIV prevalence and limited ...


Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses

24-Sep-2015 | Alvaro Ortega-Esteban; Kai Bodensiek; Carmen San Martín; Maarit Suomalainen; Urs F. Greber; Pedro J. de Pablo; Iwan ..., ACS Nano, 2015

Viruses package their genome in a robust protein coat to protect it during transmission between cells and organisms. In a reaction termed uncoating, the virus is progressively weakened during entry into cells. At the end of the uncoating process the genome separates, becomes transcriptionally ...


OpenGrowth: An Automated and Rational Algorithm for Finding New Protein Ligands

23-Sep-2015 | Nicolas Chéron; Naveen Jasty; Eugene I. Shakhnovich, Journal of Medicinal Chemistry, 2015

We present a new open-source software, called OpenGrowth, which aims to create de novo ligands by connecting small organic fragments in the active site of proteins. Molecule growth is biased to produce structures that statistically resemble drugs in an input training database. Consequently, the ...


Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation–Desulfurization Chemistry

23-Sep-2015 | Jessica Sayers; Robert E. Thompson; Kristen J. Perry; Lara R. Malins; Richard J. Payne, Organic Letters, 2015

The synthesis of a β-thiol asparagine derivative bearing a novel (2,4,6-trimethoxyphenyl)thiazolidine protecting group is described. The efficient incorporation of the amino acid into the N-termini of peptides is demonstrated as well as the utility of the β-thiol asparagine moiety for rapid ...


Impact of human mobility on the emergence of dengue epidemics in Pakistan [Ecology]

22-Sep-2015 | Amy Wesolowski; Taimur Qureshi; Maciej F. Boni; Pål Roe Sundsøy; Michael A. Johansson; Syed Basit Rasheed; Kenth Eng ..., Proceedings of the National Academy of Sciences current issue, 2015

The recent emergence of dengue viruses into new susceptible human populations throughout Asia and the Middle East, driven in part by human travel on both local and global scales, represents a significant global health risk, particularly in areas with changing climatic suitability for the mosquito ...


Electrochemical Label-free and Reagentless Genosensor Based on an Ion Barrier Switch-off System for DNA Sequence-Specific Detection of the Avian Influenza Virus

22-Sep-2015 | Katarzyna Kurzątkowska; Agnieszka Sirko; Włodzimierz Zagórski-Ostoja; Wim Dehaen; Hanna Radecka; Jerzy Radecki, Analytical Chemistry, 2015

This paper concerns the development of genosensors based on redox-active monolayers incorporating (dipyrromethene)2Cu(II) and (dipyrromethene)2Co(II) complexes formed step by step on a gold electrode surface. They were applied for electrochemical determination of oligonucleotide sequences related ...


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