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2,790 Newest Publications about the topic viruses

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Influenza A virus isolation, culture and identification

01-11-2014 | Amie J Eisfeld; Gabriele Neumann; Yoshihiro Kawaoka, Nature Protocols, 2014

Nature Protocols 9, 2663 (2014). doi:10.1038/nprot.2014.180 Authors: Amie J Eisfeld, Gabriele Neumann & Yoshihiro Kawaoka Influenza A viruses (IAVs) cause epidemics and pandemics that result in considerable financial burden and loss of human life. To manage annual IAV epidemics ...

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Antiviral drug discovery: broad-spectrum drugs from nature

21-10-2014 | J. P. Martinez; F. Sasse; M. Brönstrup; J. Diez; A. Meyerhans, Natural Product Reports, 2014

Covering: up to April 2014The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with ...

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Structure and conformational analysis of the anti-HIV reverse transcriptase inhibitor AZT using MP2 and DFT methods. Differences with the natural nucleoside thymidine. Simulation of the 1st phosphorylation step with ATP

21-10-2014 | M. Alcolea Palafox, Physical Chemistry Chemical Physics, 2014

A comprehensive quantum-chemical investigation of the conformational landscape of the HIV-1 reverse transcriptase inhibitor AZT (3′-azido-3′-deoxythymidine) nucleoside analogue was carried out. The whole conformational parameters (χ, γ, β, δ, ϕ, P, νmax) were analysed as well as the NBO charges. ...

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Bedaquiline: A New Hope to Treat Multi-Drug Resistant Tuberculosis

21-10-2014 | V. Patel, Rahul; Riyaz, Sd.; Won Park, Se, Current Topics in Medicinal Chemistry, 2014

Abstract: Each year, a huge number of new cases accounts of TB with added problems due to multidrug resistant TB varieties. Globally, TB is one of the top causes of loss of life among people living with HIV who are more likely than others to get TB infection. Current TB treatment includes ...

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Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery

21-10-2014 | L. Mallipeddi, Prema; Kumar, Gyanendra; W. White, Stephen; R. Webb, Thomas, Current Topics in Medicinal Chemistry, 2014

Abstract: Influenza is a seasonal and serious health threat, and the recent outbreak of H7N9 following the pandemic spread of H1N1 in 2009 has served to emphasize the importance of anti-influenza drug discovery. Zanamivir (Relenza™) and oseltamivir (Tamiflu®) are two antiviral drugs currently ...

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Effects of miR-33a-5P on ABCA1/G1-Mediated Cholesterol Efflux under Inflammatory Stress in THP-1 Macrophages

17-10-2014 | Min Mao et al., PLoS ONE, 2014

by Min Mao, Han Lei, Qing Liu, Yaxi Chen, Lei Zhao, Qing Li, Suxin Luo, Zhong Zuo, Quan He, Wei Huang, Nan Zhang, Chao Zhou, Xiong Z. Ruan The present study is to investigate whether inflammatory cytokines inhibit ABCA1/ABCG1-mediated cholesterol efflux by regulating miR-33a-5P in THP-1 ...

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Psychological Fears among Low-Paid Female Sex Workers in Southwest China and Their Implications for HIV Prevention

17-10-2014 | Shan Qiao et al., PLoS ONE, 2014

by Shan Qiao, Xiaoming Li, Chen Zhang, Yuejiao Zhou, Zhiyong Shen, Zhenzhu Tang, Bonita Stanton Commercial sex plays a critical role in rapidly increasing heterosexual transmission of HIV in China. Low-paid female sex workers (FSWs) are especially vulnerable to HIV/AIDS. Because of the ...

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Antiretroviral Therapy Program Expansion in Zambézia Province, Mozambique: Geospatial Mapping of Community-Based and Health Facility Data for Integrated Health Planning

17-10-2014 | Troy D. Moon et al., PLoS ONE, 2014

by Troy D. Moon, Ezequiel B. Ossemane, Ann F. Green, Elisée Ndatimana, Eurico José, Charlotte P. Buehler, C. William Wester, Sten H. Vermund, Omo Olupona Objective To generate maps reflecting the intersection of community-based Voluntary Counseling and Testing (VCT) delivery points with ...

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Q&A: Francoise Barre-Sinoussi

16-10-2014 | Iria Gomez-Touriño, Nature, 2014

Q&A: Françoise Barré-Sinoussi Nature. doi:10.1038/514S8a Author: Iria Gomez-Touriño Françoise Barré-Sinoussi and Luc Montagnier were jointly awarded the 2008 Nobel prize in Physiology or Medicine for their discovery of HIV in 1983. ...

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Computational study on the interaction between CCR5 and HIV-1 entry inhibitor maraviroc: insight from accelerated molecular dynamics simulation and free energy calculation

15-10-2014 | Qifeng Bai; Yang Zhang; Xiaomeng Li; Wenbo Chen; Huanxiang Liu; Xiaojun Yao, Physical Chemistry Chemical Physics, 2014

C–C chemokine receptor type 5 (CCR5) is the co-receptor of human immunodeficiency virus type 1 (HIV-1) and plays an important role in HIV-1 virus infection. Maraviroc has been proved to be effective for anti-HIV-1 by targeting CCR5. Understanding the detailed interaction mechanism between CCR5 ...

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