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4,083 Newest Publications about the topic viruses

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Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors

05-Dec-2016 | Author(s): Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Athri D. Rathnayake, Vishnu C. Damalanka, Pathum ..., European Journal of Medicinal Chemistry, 2016

Publication date: 27 January 2017 Source:European Journal of Medicinal Chemistry, Volume 126 Author(s): Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Athri D. Rathnayake, Vishnu C. Damalanka, Pathum M. Weerawarna, Sean T. Doyle, Amer F. Alsoudi, D.M. Padmasankha ...

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[Report] Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease

02-Dec-2016 | Benjamin M. Akiyama; Hannah M. Laurence; Aaron R. Massey; David A. Costantino; Xuping Xie; Yujiao Yang; Pei-Yong Shi ..., Science , 2016

The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by ...

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[This Week in Science] Protecting by changing the code

02-Dec-2016 | Kristen L. Mueller, Science , 2016

Vaccination Live attenuated vaccines can be very potent, but their potential to revert to their pathogenic form limits their use. In an attempt to get around this, Si et al. expanded the genetic code of influenza A viruses. They propagated viruses that were mutated to encode premature termination

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[Report] Generation of influenza A viruses as live but replication-incompetent virus vaccines

02-Dec-2016 | Longlong Si; Huan Xu; Xueying Zhou; Ziwei Zhang; Zhenyu Tian; Yan Wang; Yiming Wu; Bo Zhang; Zhenlan Niu; Chuanling ..., Science , 2016

The conversion of life-threatening viruses into live but avirulent vaccines represents a revolution in vaccinology. In a proof-of-principle study, we expanded the genetic code of the genome of influenza A virus via a transgenic cell line containing orthogonal translation machinery. This generated ...

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[This Week in Science] How bats spread viruses

02-Dec-2016 | Julia Fahrenkamp-Uppenbrink, Science , 2016

Epidemiology Bats carry numerous viruses, such as rabies and Ebola, which they can transmit to humans. In a Perspective, Hayman highlights recent genetic studies showing that male vampire bats are key to rabies dispersal and transmission in Peru. Rabies is more often transmitted between related

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Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA

02-Dec-2016 | Fardokht A. Abulwerdi; Matthew D. Shortridge; Joanna Sztuba-Solinska; Robert Wilson; Stuart F. J. Le Grice; Gabriele ..., Journal of Medicinal Chemistry, 2016

Small molecules that bind to RNA potently and specifically are relatively rare. The study of molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV genomic element, has long been an important model system for the chemistry of targeting RNA. Here we report the ...

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Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry

02-Dec-2016 | Karam El-Bayoumy; Kun-Ming Chen; Shang-Min Zhang; Yuan-Wan Sun; Shantu Amin; Gary Stoner; Joseph B. Guttenplan, Chemical Research in Toxicology, 2016

Worldwide, cancers of the oral cavity and pharynx comprise the sixth most common malignancies. Histologically, more than 90% of oral cancers are squamous cell carcinoma (SCC). Epidemiologic data strongly support the role of exogenous factors such as tobacco, alcohol, and human papilloma virus ...

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Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?

01-Dec-2016 | Ronald A. Kohanski, Steven G. Deeks, Claudia Gravekamp, Jeffrey B. Halter, Kevin High, Arti Hurria, Rebecca Fuldner, ..., Annals of the New York Academy of Sciences, 2016

Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. ...

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IJMS, Vol. 17, Pages 1990: Immune-Related Gene Expression Patterns in GPV- or H9N2-Infected Goose Spleens

01-Dec-2016 | Chen, Shun ; Wang, Anqi ; Sun, Lipei ; Liu, Fei ; Wang, Mingshu ; Jia, Renyong ; Zhu, Dekang ; Liu, Mafeng ; Yang, Q ..., International Journal of Molecular Sciences, 2016

Goose parvovirus (GPV) and avian influenza virus subtype H9N2 are single-stranded DNA (ssDNA) and single-stranded RNA (ssRNA) viruses, respectively, both of which can spread in goslings and cause a significant economic loss. To explore the comprehensive transcriptome of GPV- or H9N2-infected ...

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Chernobyl's shield, dodo skeleton and HIV vaccines

01-Dec-2016 | ;, Nature, 2016

Chernobyl's shield, dodo skeleton and HIV vaccines Nature 540, 7631 (2016). http://www.nature.com/doifinder/10.1038/540012a The week in science: 25 November–1 December 2016.

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