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3,753 Newest Publications about the topic viruses


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rno‐miR‐665 targets BCL2L1 (Bcl‐xl) and increases vulnerability to propofol in developing astrocytes

28-Apr-2016 | Wen‐Chong Sun, Ling Pei, Journal of Neurochemistry, 2016

Abstract Propofol exerts a cytotoxic influence over immature neurocytes. Our previous study revealed that clinically relevant doses of propofol accelerated apoptosis of primary cultured astrocytes of developing rodent brains via rno‐miR‐665 regulation. However, the role of rno‐miR‐665 during ...


Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity

27-Apr-2016 | Hangyu Zhou; Guangchuan Wang; Xiao-Feng Li; Yaling Li; Shun-Ya Zhu; Cheng-Feng Qin; Ruikang Tang, Chemical Communication, 2016

Developing vaccine formulations with excellent thermostability and immunogenicity remains a great challenge. By in situ encapsulating a live-attenuated strain of human enterovirus 71 (EV71) in alumina, we obtained a robust vaccine formulation named EV71@NanoAlum, which features significantly ...


Dynamic Measurements of the Position, Orientation, and DNA Content of Individual Unlabeled Bacteriophages

22-Apr-2016 | Aaron M. Goldfain; Rees F. Garmann; Yan Jin; Yoav Lahini; Vinothan N. Manoharan, Journal of Physical Chemistry B, 2016

A complete understanding of the cellular pathways involved in viral infections will ultimately require a diverse arsenal of experimental techniques, including methods for tracking individual viruses and their interactions with the host. Here we demonstrate the use of holographic microscopy to ...


[Report] The 3.8 Å resolution cryo-EM structure of Zika virus

22-Apr-2016 | Devika Sirohi; Zhenguo Chen; Lei Sun; Thomas Klose; Theodore C. Pierson; Michael G. Rossmann; Richard J. Kuhn, Science , 2016

The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome have generated worldwide concern. Zika virus is a flavivirus like the dengue, yellow fever, and West Nile viruses. We present the 3.8 angstrom resolution structure of mature ...


Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants

22-Apr-2016 | Margaret McManus; Eric Mick; Richard Hudson; Lynne M. Mofenson; John L. Sullivan; Mohan Somasundaran; Katherine Luzu ..., PLoS ONE, 2016

by Margaret McManus, Eric Mick, Richard Hudson, Lynne M. Mofenson, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, PACTG 356 Investigators The primary aim of this study was to measure HIV-1 persistence following combination antiretroviral therapy (cART) in infants and children. ...


Picosecond infrared laser-induced all-atom nonequilibrium molecular dynamics simulation of dissociation of viruses

20-Apr-2016 | Viet Hoang Man; Nguyen-Thi Van-Oanh; Philippe Derreumaux; Mai Suan Li; Christopher Roland; Celeste Sagui; Phuong H. ..., Physical Chemistry Chemical Physics, 2016

Since the discovery of the plant pathogen tobacco mosaic virus as the first viral entity in the late 1800s, viruses traditionally have been mainly thought of as pathogens for disease-resistances. However, viruses have recently been exploited as nanoplatforms with applications in biomedicine and ...


Non‐rotational Tucker3 core simplification

19-Apr-2016 | Mahin Bayat, Mohsen Kompany‐Zareh, Journal of Chemometrics, 2016

A simple and efficient approach is reported to estimate the sparsest Tucker3 model for a considered linear dependent multiway data array using PARAFAC profiles. Employing the least possible number of non‐zero core elements equal to the pseudo array rank of data, a better and easier ...


IJERPH, Vol. 13, Pages 430: Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses

19-Apr-2016 | Chen, Yi-Ning ; Hsueh, Yi-Huang ; Hsieh, Chien-Te ; Tzou, Dong-Ying ; Chang, Pai-Ling, International Journal of Environmental Research and Public Health, 2016

The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and ...


HERV-K HML-2 diversity among humans [Microbiology]

19-Apr-2016 | Jack Lenz, Proceedings of the National Academy of Sciences current issue, 2016

Retroviruses comprise over 8% of the human genome (1, 2). Human endogenous retroviruses (HERVs) exist as DNA remnants of infections that occurred in germ lineage cells of our ancestors. Most of this viral DNA is mutated, often including various large disruptions, but some components are intact or ...


Long antibody HCDR3s from HIV-naive donors presented on a PG9 neutralizing antibody background mediate HIV neutralization [Immunology and Inflammation]

19-Apr-2016 | Jordan R. Willis; Jessica A. Finn; Bryan Briney; Gopal Sapparapu; Vidisha Singh; Hannah King; Celia C. LaBranche; Da ..., Proceedings of the National Academy of Sciences current issue, 2016

Development of broadly neutralizing antibodies (bnAbs) against HIV-1 usually requires prolonged infection and induction of Abs with unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops. Here we sought to determine whether the repertoires of HIV-1–naïve ...


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