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4,326 Newest Publications about the topic viruses

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IJMS, Vol. 18, Pages 1103: Immunobiology of Newcastle Disease Virus and Its Use for Prophylactic Vaccination in Poultry and as Adjuvant for Therapeutic Vaccination in Cancer Patients

20-May-2017 | Schirrmacher, Volker, International Journal of Molecular Sciences, 2017

Newcastle disease (ND) is one of the most important diseases of poultry worldwide. In the last decades, molecular research has gained a lot of new information about its causative agent, newcastle disease virus (NDV). In poultry industry, certain strains of NDV have been used for preventive ...

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An Aggregating Amphiphilic Squaraine: A Light‐up Probe That Discriminates Parallel G‐Quadruplexes

19-May-2017 | Vincenzo Grande, Filippo Doria, Mauro Freccero, Frank Würthner, Angewandte Chemie International Edition, 2017

Abstract G‐quadruplexes (G4s) are peculiar DNA or RNA tertiary structures that are involved in the regulation of many biological events within mammalian cells, bacteria, and viruses. Although their role as versatile therapeutic targets has been emphasized for 35 years, G4 selectivity over ...

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Identification of Multiple Druggable Secondary Sites by Fragment Screening against DC‐SIGN

19-May-2017 | Jonas Aretz, Hannes Baukmann, Elena Shanina, Jonas Hanske, Robert Wawrzinek, Viktor A. Zapol'skii, Peter H. Seeberge ..., Angewandte Chemie International Edition, 2017

Abstract DC‐SIGN is a cell‐surface receptor for several pathogenic threats, such as HIV, Ebola virus, or Mycobacterium tuberculosis. Multiple attempts to develop inhibitors of the underlying carbohydrate–protein interactions have been undertaken in the past fifteen years. Still, drug‐like ...

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Taking HIV to the gut

19-May-2017 | Anand Balasubramani, Science , 2017

HIV Antiretroviral therapy (ART) effectively limits HIV replication. Nevertheless, HIV+ individuals need to be medicated for life because ART withdrawal results in rebound of persistent virus. One emerging approach to target HIV is an antibody against integrin α4β7. Integrin α4β7 is a receptor

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HTLV-1 Associated Neurological Disorders

18-May-2017 | Yasir Khan, Muhammad; Nasib Khan, Ishaq; Farman, Muhammad; Al Karim, Saleh; Qadri, Ishtiaq; Amjad Kamal, Muhammad; A ..., Current Topics in Medicinal Chemistry, 2017

Abstract: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus which is endemic to certain regions of the world and infects around 10-20 million people. HTLV-1 is the etiologic agent of Adult T cell leukemia/lymphoma and HTLV-1 associated neurological disorders including mainly ...

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Correction to Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120

18-May-2017 | Francesca Curreli; Young Do Kwon; Dmitry S. Belov; Ranjith R. Ramesh; Alexander V. Kurkin; Andrea Altieri; Peter D. ..., Journal of Medicinal Chemistry, 2017

Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.7b00690

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Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

17-May-2017 | Hui Cai; Jared Orwenyo; Javier Guenaga; John Giddens; Christian Toonstra; Richard T. Wyatt; Lai-Xi Wang, Chemical Communication, 2017

We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could ...

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Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

15-May-2017 | Dongwei Kang; Zengjun Fang; Boshi Huang; Xueyi Lu; Heng Zhang; Haoran Xu; Zhipeng Huo; Zhongxia Zhou; Zhao Yu; Qing ..., Journal of Medicinal Chemistry, 2017

This work follows on from our initial discovery of a series of piperidine-substituted thiophene[3,2-d]pyrimidine HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTI) (J. Med. Chem. 2016, 59, 7991−8007). In the present study, we designed, synthesized, and biologically tested several ...

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Application of monolithic chromatographic supports in virus research

12-May-2017 | Mladen Krajacic, Maja Ravnikar, Aleš Štrancar, Ion Gutiérrez‐Aguirre, ELECTROPHORESIS, 2017

Key properties of monolithic chromatographic supports, make them suitable for separation and/or concentration of large biomolecules, especially virus particles and viral genomes. One by one, the studies that have been completed so far, contributed to the knowledge that monolith chromatography ...

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Pinpointing HIV spread in Africa poses risks

12-May-2017 | Jon Cohen, Science , 2017

For the first time, researchers, ethicists, lawyers, and community representatives will meet to discuss balancing the public health benefits and the potential risks of creating a massive database of HIV sequences from people living in sub-Saharan Africa. ThePhylogenetics and Networks for ...

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