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2,842 Newest Publications about the topic viruses


Folded Monomers and Hexamers of the Ectodomain of the HIV gp41 Membrane Fusion Protein: Potential Roles in Fusion and Synergy Between the Fusion Peptide, Hairpin, and Membrane-Proximal External Region

14-11-2014 | Koyeli Banerjee; David P. Weliky, Biochemistry, 2014

HIV is an enveloped virus and fusion between the HIV and host cell membranes is catalyzed by the ectodomain of the HIV gp41 membrane protein. Both the N-terminal fusion peptide (FP) and C-terminal membrane-proximal external region (MPER) are critical for fusion and are postulated to bind to the ...


Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection

14-11-2014 | Deborah H. Strickland et al., PLoS ONE, 2014

by Deborah H. Strickland, Vanessa Fear, Seth Shenton, Mathew E. Wikstrom, Graeme Zosky, Alexander N. Larcombe, Patrick G. Holt, Cassandra Berry, Christophe von Garnier, Philip A. Stumbles Immunological homeostasis in the respiratory tract is thought to require balanced interactions between ...


IJERPH, Vol. 11, Pages 11805-11821: Factors Contributing to the Risk of HIV Infection in Rural School-Going Adolescents

14-11-2014 | Awotidebe, Adedapo ; Phillips, Julie ; Lens, Willy, International Journal of Environmental Research and Public Health, 2014

The objective of this study was to determine the factors that increase the risk of HIV infection in rural school-going adolescents and young adults. This was a cross-sectional study of 430 secondary school students (47.4% boys and 52.6% girls) from two rural schools in South Africa. Data were ...


Sensors, Vol. 14, Pages 21409-21417: Using Bio-Functionalized Magnetic Nanoparticles and Dynamic Nuclear Magnetic Resonance to Characterize the Time-Dependent Spin-Spin Relaxation Time for Sensitive Bio-Detection

12-11-2014 | Liao, Shu-Hsien ; Chen, Kuen-Lin ; Wang, Chun-Ming ; Chieh, Jen-Jie ; Horng, Herng-Er ; Wang, Li-Min ; Wu, C. H.; Ya ..., Sensors, 2014

In this work, we report the use of bio-functionalized magnetic nanoparticles (BMNs) and dynamic magnetic resonance (DMR) to characterize the time-dependent spin-spin relaxation time for sensitive bio-detection. The biomarkers are the human C-reactive protein (CRP) while the BMNs are the anti-CRP ...


Na+,K+-ATPase Isoform Selectivity for Digitalis-Like Compounds Is Determined by Two Amino Acids in the First Extracellular Loop

12-11-2014 | Karl M. Weigand; Mette Laursen; Herman G. P. Swarts; Anthonius H. J. Engwerda; Christian Prüfert; Julia Sandrock; Po ..., Chemical Research in Toxicology, 2014

Digitalis-like compounds (DLCs) comprise a diverse group of molecules characterized by a cis–trans–cis ring-fused steroid core linked to a lactone. They have been used in the treatment of different medical problems including heart failure, where their inotropic effect on heart muscle is ...


IJERPH, Vol. 11, Pages 11583-11596: Mosquito Surveillance for Prevention and Control of Emerging Mosquito-Borne Diseases in Portugal — 2008–2014

12-11-2014 | Osório, Hugo C.; Zé-Zé, Líbia ; Amaro, Fátima ; Alves, Maria J., International Journal of Environmental Research and Public Health, 2014

Mosquito surveillance in Europe is essential for early detection of invasive species with public health importance and prevention and control of emerging pathogens. In Portugal, a vector surveillance national program—REVIVE (REde de VIgilância de VEctores)—has been operating since 2008 under the ...


IJMS, Vol. 15, Pages 20723-20735: Synthesis and Biological Evaluation of 2-Thioxopyrimidin-4(1H)-one Derivatives as Potential Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

12-11-2014 | Khalifa, Nagy M.; Al-Omar, Mohamed A., International Journal of Molecular Sciences, 2014

A series of new 5-allyl-6-benzylpyrimidin-4(3H)-ones bearing different substituents at the C-2 position of the pyrimidine core have been synthesized and evaluated for their in vitro activities against human immunodeficiency virus type 1 (HIV-1) in the human T-lymphotropic type (MT-4 cell ...


Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease [Biophysics and Computational Biology]

11-11-2014 | Ayşegül Özen; Kuan-Hung Lin; Nese Kurt Yilmaz; Celia A. Schiffer, Proceedings of the National Academy of Sciences current issue, 2014

Drug resistance mutations in response to HIV-1 protease inhibitors are selected not only in the drug target but elsewhere in the viral genome, especially at the protease cleavage sites in the precursor protein Gag. To understand the molecular basis of this protease–substrate coevolution, we ...


Impact of early-stage HIV transmission on treatment as prevention [Population Biology]

11-11-2014 | Kimberly A. Powers; Mirjam E. Kretzschmar; William C. Miller; Myron S. Cohen, Proceedings of the National Academy of Sciences current issue, 2014

Timely HIV treatment improves health (1) and reduces transmission (2). These individual-level benefits of HIV treatment for both clinical and preventive purposes are well established, but several questions remain about the population-level impact of HIV treatment as prevention (3). In PNAS, Eaton ...


Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells [Microbiology]

11-11-2014 | Korneel Grauwet; Claudia Cantoni; Monica Parodi; Andrea De Maria; Bert Devriendt; Daniela Pende; Lorenzo Moretta; Ma ..., Proceedings of the National Academy of Sciences current issue, 2014

Natural killer (NK) cells are key players in the innate response to viruses, including herpesviruses. In particular, the variety of viral strategies to modulate the recognition of certain herpesviruses witnesses the importance of NK cells in the control of this group of viruses. Still, NK evasion ...


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