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3,605 Newest Publications about the topic viruses

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Identification of a binding site of the human immunodeficiency virus envelope protein gp120 to neuronal specific tubulin

30-Jan-2016 | Valeria Avdoshina, Francesca Taraballi, Simona Dedoni, Claudia Corbo, Mikell Paige, Yasemin Saygideğer Kont, Aykut Ü ..., Journal of Neurochemistry, 2016

Abstract Human immunodeficiency virus‐1 (HIV) promotes synaptic simplification and neuronal apoptosis, and causes neurological impairments termed HIV‐associated neurological disorders (HAND). HIV‐associated neurotoxicity may be brought about by acute and chronic mechanisms that still remain to ...

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Correction: Evaluating the Early Benefit of Quadrivalent HPV Vaccine on Genital Warts in Belgium: A Cohort Study

29-Jan-2016 | Geraldine Dominiak-Felden et al., PLoS ONE, 2016

by Geraldine Dominiak-Felden, Corrado Gobbo, François Simondon

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[In Depth] Researchers claim to find HIV sanctuaries

29-Jan-2016 | Jon Cohen, Science , 2016

A new study stirs a longstanding debate and suggests that the way to cure HIV infections may be to make drugs that better reach "sanctuary sites" like the lymph node. Antiretroviral (ARV) drugs routinely knock HIV down so effectively that standard tests can't detect the virus. But most everyone ...

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Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

29-Jan-2016 | Fang Li; Chunlong Ma; William F. DeGrado; Jun Wang, Journal of Medicinal Chemistry, 2016

With the emergence of highly pathogenic avian influenza (HPAI) H7N9 and H5N1 strains, there is a pressing need to develop direct-acting antivirals (DAAs) to combat such deadly viruses. The M2-S31N proton channel of the influenza A virus (A/M2) is one of the validated and most conserved proteins ...

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Fragment‐Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease

28-Jan-2016 | Jonathan E. Gable, Gregory M. Lee, Timothy M. Acker, Kaitlin R. Hulce, Eric R. Gonzalez, Patrick Schweigler, Samu Me ..., ChemMedChem, 2016

Abstract Fragment‐based drug discovery has shown promise as an approach for challenging targets such as protein–protein interfaces. We developed and applied an activity‐based fragment screen against dimeric Kaposi's sarcoma‐associated herpesvirus protease (KSHV Pr) using an optimized ...

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Molecules, Vol. 21, Pages 154: An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines

28-Jan-2016 | Varvounis, George, Molecules, 2016

Pyrrolo[1,4]benzodiazepines are tricyclic compounds that are considered “privileged structures” since they possess a wide range of biological activities. The first encounter with these molecules was the isolation of anthramycin from cultures of Streptomyces, followed by determination of the X-ray ...

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Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

27-Jan-2016 | Zhiyong Song; Long Liu; Xiaoyu Wang; Yongqiang Deng; Qinggong Nian; Guangchuan Wang; Shunya Zhu; Xiaofeng Li; Hangyu ..., Chemical Communication, 2016

Conventional therapeutic monoclonal antibodies (mAbs) are invalid for intracellular viruses but by using in situ biomineralization treatment, they can be successfully delivered into cells to inhibit intracellular viral replication. This achievement significantly expands the applications of mAbs ...

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Turning point: Louis Picker

27-Jan-2016 | Virginia Gewin, Nature, 2016

Turning point: Louis Picker Nature 529, 7587 (2016). doi:10.1038/nj7587-557a Author: Virginia Gewin Louis Picker pursued an unusual HIV vaccine that is now in clinical trials, and was once considered a fool's errand.

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Exploring the role of the [small alpha]-carboxyphosphonate moiety in the HIV-RT activity of [small alpha]-carboxy nucleoside phosphonates

26-Jan-2016 | Anita R Maguire; Nicholas D Mullins; Nuala M Maguire; Alan Ford; Kalyan Das; Edward Arnold; Jan Balzarini, Organic & Biomolecular Chemistry, 2016

Org. Biomol. Chem., 2016, Accepted ManuscriptDOI: 10.1039/C5OB02507A, Paper Anita R Maguire, Nicholas D Mullins, Nuala M Maguire, Alan Ford, Kalyan Das, Edward Arnold, Jan BalzariniThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted ...

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Molecules, Vol. 21, Pages 150: Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities

26-Jan-2016 | Gong, Kai-Kai ; Tang, Xu-Li ; Liu, Yi-Sheng ; Li, Ping-Lin ; Li, Guo-Qiang, Molecules, 2016

Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one ...

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