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3,807 Newest Publications about the topic viruses

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The discovery of allyl-tyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction

25-May-2016 | Neal Dalton; Christopher Gordon; Timothy B Boyle; Nicholas Vandegraaf; John Deadman; David I Rhodes; Jonathan A Coat ..., Organic & Biomolecular Chemistry, 2016

From library screening of synthetic antimicrobial peptides, an O-allyltyrosine-based tripeptide was identified to possess inhibitory activity against HIV-1 integrase (IN) exhibiting an IC50 value of 17.5 μM in a combination 3'-processing and strand transfer microtitre plate assay. The tripeptide ...

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Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S

22-May-2016 | Author(s): Elżbieta Plebanek, Florian Chevrier, Vincent Roy, Thibault Garenne, Fabien Lecaille, Dawid Wa ..., European Journal of Medicinal Chemistry, 2016

Publication date: 4 October 2016 Source:European Journal of Medicinal Chemistry, Volume 121 Author(s): Elżbieta Plebanek, Florian Chevrier, Vincent Roy, Thibault Garenne, Fabien Lecaille, Dawid Warszycki, Andrzej J. Bojarski, Gilles Lalmanach, Luigi A. Agrofoglio The ...

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Structure-activity relationships of 3-O-β-chacotriosyl oleanane-type triterpenoids as potential H5N1 entry inhibitors

22-May-2016 | Author(s): Gaopeng Song, Xintian Shen, Sumei Li, Yibin Li, Hongzong Si, Jihong Fan, Junhua Li, Erqiang ..., European Journal of Medicinal Chemistry, 2016

Publication date: 25 August 2016 Source:European Journal of Medicinal Chemistry, Volume 119 Author(s): Gaopeng Song, Xintian Shen, Sumei Li, Yibin Li, Hongzong Si, Jihong Fan, Junhua Li, Erqiang Gao, Shuwen Liu A series of 3-O-β-chacotriosyl oleanolic acid analogs have ...

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Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells

22-May-2016 | Author(s): Necla Kulabaş, Esra Tatar, Özlem Bingöl Özakpınar, Derya Özsavcı, Christophe Pannecouque, Erik ..., European Journal of Medicinal Chemistry, 2016

Publication date: 4 October 2016 Source:European Journal of Medicinal Chemistry, Volume 121 Author(s): Necla Kulabaş, Esra Tatar, Özlem Bingöl Özakpınar, Derya Özsavcı, Christophe Pannecouque, Erik De Clercq, İlkay Küçükgüzel In this study, a series of thiosemicarbazide ...

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Retroviral DNA Integration

20-May-2016 | Paul Lesbats; Alan N. Engelman; Peter Cherepanov, Chemical Reviews, 2016

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among retroviruses and LTR-retrotransposons. Retroviral integration proceeds via ...

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Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells

20-May-2016 | PSS Rao; Anusha Ande; Namita Sinha; Anil Kumar; Santosh Kumar, PLoS ONE, 2016

by PSS Rao, Anusha Ande, Namita Sinha, Anil Kumar, Santosh Kumar While cigarette smoking is prevalent amongst HIV-infected patients, the effects of cigarette smoke constituents in cells of myeloid lineage are poorly known. Recently, we have shown that nicotine induces oxidative stress through ...

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Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status

20-May-2016 | Julie Gauvin; Josiane Chagnon-Choquet; Johanne Poudrier; Michel Roger; Montreal Primary HIV Infection and Slow Progr ..., PLoS ONE, 2016

by Julie Gauvin, Josiane Chagnon-Choquet, Johanne Poudrier, Michel Roger, Montreal Primary HIV Infection and Slow Progressor Cohorts We have previously shown that overexpression of BLyS/BAFF was associated with increased relative frequencies of innate “precursor” marginal zone (MZ)-like ...

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[Report] Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo

20-May-2016 | Ching-Lan Lu; Dariusz K. Murakowski; Stylianos Bournazos; Till Schoofs; Debolina Sarkar; Ariel Halper-Stromberg; Jos ..., Science , 2016

Antiretroviral drugs and antibodies limit HIV-1 infection by interfering with the viral life cycle. In addition, antibodies also have the potential to guide host immune effector cells to kill HIV-1–infected cells. Examination of the kinetics of HIV-1 suppression in infected individuals by ...

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[Report] HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

20-May-2016 | Till Schoofs; Florian Klein; Malte Braunschweig; Edward F. Kreider; Anna Feldmann; Lilian Nogueira; Thiago Oliveira; ..., Science , 2016

3BNC117 is a broad and potent neutralizing antibody to HIV-1 that targets the CD4 binding site on the viral envelope spike. When administered passively, this antibody can prevent infection in animal models and suppress viremia in HIV-1–infected individuals. Here we report that HIV-1 immunotherapy ...

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[Feature] The Truest Test

20-May-2016 | Jon Cohen, Science , 2016

Over the past few years, there has been a surge in studies that intentionally infect volunteers with a wide variety of pathogens to test novel drugs and vaccines. The so-called "human challenge model" has a long and checkered past that began with 18th century experiments by smallpox vaccine ...

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