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4,287 Newest Publications about the topic viruses

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Packaged and Free Satellite Tobacco Mosaic Virus (STMV) RNA Genomes Adopt Distinct Conformational States

16-Apr-2017 | Bridget C. Larman; Elizabeth A. Dethoff; Kevin M. Weeks, Biochemistry, 2017

The RNA genomes of viruses likely undergo multiple functionally important conformational changes during their replication cycles, changes that are poorly understood at present. We used two complementary in-solution RNA structure probing strategies (SHAPE-MaP and RING-MaP) to examine the structure ...

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Factors influencing postnatal Option B+ participation and breastfeeding duration among HIV-positive women in Lilongwe District, Malawi: A qualitative study

14-Apr-2017 | Valerie L. Flax; Gloria Hamela; Innocent Mofolo; Mina C. Hosseinipour; Irving F. Hoffman; Suzanne Maman, PLoS ONE, 2017

by Valerie L. Flax, Gloria Hamela, Innocent Mofolo, Mina C. Hosseinipour, Irving F. Hoffman, Suzanne Maman To ensure the health of mothers and children, prevention of mother-to-child HIV transmission (PMTCT) programs test women for HIV, engage HIV-positive women in care, and promote recommended ...

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Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

14-Apr-2017 | Susana V. Bardina; Paul Bunduc; Shashank Tripathi; James Duehr; Justin J. Frere; Julia A. Brown; Raffael Nachbagauer ..., Science , 2017

Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are endemic. Antibody-dependent enhancement has been implicated in more severe forms of flavivirus disease, but whether this also applies to ZIKV ...

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Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors

14-Apr-2017 | Anneleen Van Hout; Thomas D’huys; Merel Oeyen; Dominique Schols; Tom Van Loy, PLoS ONE, 2017

by Anneleen Van Hout, Thomas D’huys, Merel Oeyen, Dominique Schols, Tom Van Loy The chemokine receptor CXCR4 is activated by its unique chemokine ligand CXCL12 and regulates many physiological and developmental processes such as hematopoietic cell trafficking. CXCR4 is also one of the main ...

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Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015

14-Apr-2017 | Nipaporn Tewawong; Preeyaporn Vichiwattana; Sumeth Korkong; Sirapa Klinfueng; Nungruthai Suntronwong; Thanunrat Thon ..., PLoS ONE, 2017

by Nipaporn Tewawong, Preeyaporn Vichiwattana, Sumeth Korkong, Sirapa Klinfueng, Nungruthai Suntronwong, Thanunrat Thongmee, Apiradee Theamboonlers, Sompong Vongpunsawad, Yong Poovorawan The neuraminidase inhibitors (NAIs) oseltamivir and zanamivir are commonly used for the treatment and ...

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Steroidogenic acute regulatory protein (StAR) overexpression reduces inflammation and insulin resistance in obese mice

12-Apr-2017 | Yanyan Qiu, Xianxian Sui, Shengxuan Cao, Xiaobo Li, Yanxia Ning, Songmei Wang, Lianhua Yin, Xiuling Zhi, Journal of Cellular Biochemistry, 2017

Abstract Steroidogenic acute regulatory protein (StAR), a mitochondrial cholesterol delivery protein, plays a beneficial role in hyperlipidemia, NAFLD and endothelial inflammation. Elevated circulating fatty acids and low grade inflammation are known as key risk factors of insulin resistance ...

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Revisiting a Classic Transformation: A Lossen Rearrangement Initiated by Nitriles and “Pseudo-Catalytic” in Isocyanate

12-Apr-2017 | Neil A. Strotman; Adrian Ortiz; Scott A. Savage; Christopher R. Wilbert; Sloan Ayers; Susanne Kiau, The Journal of Organic Chemistry, 2017

The direct conversion of a hydroxamic acid to an amine has been accomplished in a single step in the synthesis of HIV drug candidate BMS-955176. This process utilizes catalytic base and proceeds under mild conditions (CH3CN, cat. DBU, 60 °C), without the need for strong electrophiles required for ...

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IJMS, Vol. 18, Pages 808: SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation

12-Apr-2017 | Zhang, Xiaoyan ; Wang, Hao ; Wang, Hua ; Xiao, Fengjun ; Seth, Prem ; Xu, Weidong ; Jia, Qinghua ; Wu, Chutse ; Yang ..., International Journal of Molecular Sciences, 2017

In advanced prostate cancer, small ubiquitin-like modifier (SUMO)-specific cysteine protease 1 (SENP1) is up-regulated. However, the role of SENP1 in regulating deSUMOylation of TGF-β/SMADs signaling is unknown. In this study, we developed a lentiviral vector, PLKO.1-shSENP1, to silence SENP1 in ...

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Effectiveness of UNAIDS targets and HIV vaccination across 127 countries [Population Biology]

11-Apr-2017 | Jan Medlock; Abhishek Pandey; Alyssa S. Parpia; Amber Tang; Laura A. Skrip; Alison P. Galvani, Proceedings of the National Academy of Sciences current issue, 2017

The HIV pandemic continues to impose enormous morbidity, mortality, and economic burdens across the globe. Simultaneously, innovations in antiretroviral therapy, diagnostic approaches, and vaccine development are providing novel tools for treatment-as-prevention and prophylaxis. We developed a ...

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Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma [Genetics]

11-Apr-2017 | Supawadee Chawanthayatham; Charles C. Valentine III; Bogdan I. Fedeles; Edward J. Fox; Lawrence A. Loeb; Stuart S. L ..., Proceedings of the National Academy of Sciences current issue, 2017

Aflatoxin B1 (AFB1) and/or hepatitis B and C viruses are risk factors for human hepatocellular carcinoma (HCC). Available evidence supports the interpretation that formation of AFB1-DNA adducts in hepatocytes seeds a population of mutations, mainly G:C→T:A, and viral processes synergize to ...

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