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3,461 Newest Publications about the topic viruses


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Theoretical studies of energetics and binding isotope effects of binding a triazole-based inhibitor to HIV-1 reverse transcriptase

25-Nov-2015 | Agnieszka Krzemińska; Katarzyna Swiderek; Piotr Paneth, Physical Chemistry Chemical Physics, 2015

Understanding of protein-ligands interactions is crucial for rational drug design. Binding isotope effects, BIEs, can provide intimate details of specific interactions between individual atoms of an inhibitor and the binding pocket. We have applied multi-scale QM/MM simulations to evaluate ...


[Feature] What does a disease deserve?

20-Nov-2015 | Jocelyn Kaiser, Science , 2015

Since the early 1990s, Congress and the National Institutes of Health (NIH) have agreed to dedicate roughly 10% of the NIH budget to fighting HIV/AIDS. Now, however, that special arrangement is under fire. Health policy experts, lawmakers, and even NIH officials have wondered why, 2 decades after ...


Multimerized HIV‐gp41‐derived Peptides as Fusion Inhibitors and Vaccines†

20-Nov-2015 | Wataru Nomura, Takaaki Mizuguchi, Hirokazu Tamamura, Peptide Science, 2015

ABSTRACT To date, several antigens based on the amino‐terminal leucine/isoleucine heptad repeat (NHR) region of an HIV‐1 envelope protein gp41 and fusion inhibitors based on the carboxy‐terminal leucine/isoleucine heptad repeat (CHR) region of gp41 have been reported. We have developed a ...


New directions for protease inhibitors directed drug discovery†

20-Nov-2015 | Yoshio Hamada, Yoshiaki Kiso, Peptide Science, 2015

Abstract Proteases play crucial roles in various biological processes, and their activities are essential for all living organisms – from viruses to humans. Since their functions are closely associated with many pathogenic mechanisms, their inhibitors or activators are important molecular ...


N‐linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent

19-Nov-2015 | Cristina De Castro, Immacolata Speciale, Garry Duncan, David D. Dunigan, Irina Agarkova, Rosa Lanzetta, Luisa Sturia ..., Angewandte Chemie International Edition, 2015

Abstract N‐glycosylation is a fundamental modification of proteins and exists in the three domains of life and in some viruses, including the chloroviruses, for which a new type of core N‐glycan is herein described. This N‐glycan core structure, common to all chloroviruses, is a ...


Molecules, Vol. 20, Pages 20614-20641: Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

19-Nov-2015 | Woźniak, Łukasz ; Skąpska, Sylwia ; Marszałek, Krystian, Molecules, 2015

Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are ...


Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses

19-Nov-2015 | Kuan-Chieh Ching; Yiu-Wing Kam; Andres Merits; Lisa F. P. Ng; Christina L. L. Chai, Journal of Medicinal Chemistry, 2015

Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus and is transmitted to humans by Aedes mosquitoes. Despite the re-emergence of CHIKV as an epidemic threat, there is no approved effective antiviral treatment currently available for CHIKV. Herein, we report the synthesis and ...


Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold

18-Nov-2015 | P. R. Werkhoven; M. Elwakiel; T. J. Meuleman; H. C. Quarles van Ufford; J. A. W. Kruijtzer; R. M. J. Liskamp, Organic & Biomolecular Chemistry, 2015

Mimics of discontinuous epitopes of for example bacterial or viral proteins may have considerable potential for the development of synthetic vaccines, especially if conserved epitopes can be mimicked. However, due to the structural complexity and size of discontinuous epitopes molecular ...


Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis [Microbiology]

17-Nov-2015 | Riccardo Dolcetti; Cinzia Giagulli; Wangxiao He; Marina Selleri; Francesca Caccuri; Lindsay M. Eyzaguirre; Pietro Ma ..., Proceedings of the National Academy of Sciences current issue, 2015

Although in decline after successful anti-HIV therapy, B-cell lymphomas are still elevated in HIV-1-seropositive (HIV+) persons, and the mechanisms are obscure. The HIV-1 matrix protein p17 persists in germinal centers long after HIV-1 drug suppression, and some p17 variants (vp17s) activate Akt ...


Persistent impacts of West Nile virus on North American bird populations [Ecology]

17-Nov-2015 | T. Luke George; Ryan J. Harrigan; Joseph A. LaManna; David F. DeSante; James F. Saracco; Thomas B. Smith, Proceedings of the National Academy of Sciences current issue, 2015

Since its introduction to North America in 1999, West Nile virus (WNV) has had devastating impacts on native host populations, but to date these impacts have been difficult to measure. Using a continental-scale dataset comprised of a quarter-million birds captured over nearly two decades and a ...


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