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2,896 Newest Publications about the topic viruses


CPMV induced synthesis of Hollow-porous SiO2 Nanocapsules with excellent performance in Drug delivery

17-12-2014 | Koushi Kumar; Pradip Paik, Dalton Transactions, 2014

An idiosyncratic hollow mesoporous-SiO2 nanocapsule has been synthesized at room temperature using unmodified Cowpea mosaic Virus (CPMV) as a template, and without using any catalyst or surfactant during synthesis. The average size of the capsules synthesized is ~200-250 nm with 60-100 nm hollow ...


Identification of benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

16-12-2014 | Fudi Zhong; Guannan Geng; Bing Chen; Ting Pan; Qianwen Li; Hui Zhang; Chuan Bai, Organic & Biomolecular Chemistry, 2014

Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this study, we have screened a commercial library and identified the hit compound 1 bearing a benzenesulfonamide ...


[Perspective] Expanding the breadth of an HIV-1 vaccine

12-12-2014 | Gilad Ofek; Ron Diskin, Science , 2014

Immunogens are designed to elicit the production of highly coveted broadly neutralizing antibodies that protect against HIV-1 [Also see Report by McGuire et al.] Authors: Gilad Ofek, Ron Diskin


Evolutionary Phylodynamics of Korean Noroviruses Reveals a Novel GII.2/GII.10 Recombination Event

12-12-2014 | Thoi Cong Truong et al., PLoS ONE, 2014

by Thoi Cong Truong, Van Thai Than, Wonyong Kim Viral gastroenteritis is the most common causal agent of public health problems worldwide. Noroviruses cause nonbacterial acute gastroenteritis in humans of all ages. In this study, we investigated the occurrence of norovirus infection in children ...


[Report] Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies

12-12-2014 | Andrew T. McGuire; Anita M. Dreyer; Sara Carbonetti; Adriana Lippy; Jolene Glenn; Johannes F. Scheid; Hugo Mouquet; ..., Science , 2014

Higher affinities let narrow neutralizing HIV antibodies outcompete broadly neutralizing HIV antibodies early in infection. [Also see Perspective by Ofek and Diskin] Authors: Andrew T. McGuire, Anita M. Dreyer, Sara Carbonetti, Adriana Lippy, Jolene Glenn, Johannes F. Scheid, Hugo Mouquet, ...


This Week in Science

12-12-2014 | Sacha Vignieri, Science , 2014

“Green” revolution not so great for pollinators | Watching electrons dart through silicon | Metal-organic framework material membranes | A fierce competition to attack HIV | The frontline of host-pathogen coevolution | Dialogue opens the door to attitude change | Laser shock imprinting for ...


Peripheral Arterial Disease and Ankle-Brachial Index Abnormalites in Young and Middle-Aged HIV-Positive Patients in Lower Silesia, Poland

12-12-2014 | Wiesława Kwiatkowska et al., PLoS ONE, 2014

by Wiesława Kwiatkowska, Brygida Knysz, Katarzyna Arczyńska, Justyna Drelichowska, Marcin Czarnecki, Jacek Gąsiorowski, Maciej Karczewski, Wojciech Witkiewicz Background Peripheral arterial disease (PAD) is a clinical manifestation of atherosclerosis and mainly refers to elderly patients, ...


Human Rhinovirus Induced Cytokine/Chemokine Responses in Human Airway Epithelial and Immune Cells

12-12-2014 | Devi Rajan et al., PLoS ONE, 2014

by Devi Rajan, Courtney E. McCracken, Hannah B. Kopleman, Shuya Y. Kyu, F. Eun-Hyung Lee, Xiaoyan Lu, Larry J. Anderson Infections with human rhinovirus (HRV) are commonly associated with acute upper and lower respiratory tract disease and asthma exacerbations. The role that HRVs play in these ...


Tailor‐Made Antimicrobial/Antiviral Star Polymer via ATRP of Cyclodextrin and Guanidine‐Based Macromonomer

09-12-2014 | Yuanfeng Pan, Yan Xue, Jamie Snow, Huining Xiao, Macromolecular Chemistry and Physics, 2014

Novel star‐like polymers are prepared via atom transfer radical polymerization (ATRP) of polyhexamethylene guanidine hydrochloride (PHMG) macromonomer and acrylamide (AM) using β‐cyclodextrin (CD) with 8‐active and 5‐active sites as a macroinitiator. The resulting star‐like polymers are ...


Long‐term oral resveratrol intake provides nutritional preconditioning against myocardial ischemia/reperfusion injury: involvement of VDAC1 down‐regulation

09-12-2014 | Zhangping Liao, Dan Liu, Lei Tang, Dong Yin, Shuhua Yin, Songqing Lai, Jianguo Yao, Ming He, Molecular Nutrition & Food Research, 2014

Scope : This study elucidates effects of long term nutritional preconditioning by resveratrol on I/R injury and its underlying mechanisms. Methods and results : Mice were treated with resveratrol at 2.0 mg/ by gastric gavages for 6 weeks. Then hearts were isolated and subjected to ...


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