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3,863 Newest Publications about the topic viruses

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Thermodynamics of Cell-Penetrating HIV1 TAT Peptide Insertion into PC/PS/CHOL Model Bilayers through Transmembrane Pore: the Roles of Cholesterol and Anionic Lipid

19-Jul-2016 | Sandeep Patel; Yuan Hu, Soft Matter, 2016

Efficient delivery of poor permeation molecules across cell membrane by using cell penetrating peptides (CPPs), such as cationic human immunodeficiency virus-1 trans-acting activator of transcription peptide (HIV-1 TAT), attracts significant attention in drug design and disease treatment. ...

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[In Brief] News at a glance

15-Jul-2016 | American Association for the Advancement of Science, Science , 2016

SCI COMMUNIn science news around the world, the United States sets final safety regulations for oil and gas drilling in its Arctic waters, Australian researchers announce that the AIDS epidemic in the country is over—but caution that too many people are still being infected with HIV, the U.S. ...

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Discovery of HIV Type 1 Aspartic Protease Hit Compounds through Combined Computational Approaches

14-Jul-2016 | Dimitrios Xanthopoulos, Eftichia Kritsi, Claudiu T. Supuran, Manthos G. Papadopoulos, Georgios Leonis, Panagiotis Zo ..., ChemMedChem, 2016

Abstract A combination of computational techniques and inhibition assay experiments was employed to identify hit compounds from commercial libraries with enhanced inhibitory potency against HIV type 1 aspartic protease (HIV PR). Extensive virtual screening with the aid of reliable ...

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IJMS, Vol. 17, Pages 1125: Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer

14-Jul-2016 | Hojeij, Rim ; Domingos-Pereira, Sonia ; Nkosi, Marianne ; Gharbi, Dalila ; Derré, Laurent ; Schiller, John T.; Jichl ..., International Journal of Molecular Sciences, 2016

Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used ...

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South Africa ushers in a new era for HIV

14-Jul-2016 | Nordling, Linda;, Nature, 2016

South Africa ushers in a new era for HIV Nature 535, 7611 (2016). http://www.nature.com/doifinder/10.1038/535214a Author: Linda Nordling The country has developed the biggest programme of antiretroviral therapy in the world. Now ...

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Conformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study

11-Jul-2016 | Naima G. Sharaf; Rieko Ishima; Angela M. Gronenborn, Biochemistry, 2016

HIV-1 reverse transcriptase (RT) is a major drug target in the treatment of HIV-1 infection. RT inhibitors currently in use include non-nucleoside, allosteric RT inhibitors (NNRTIs), which bind to a hydrophobic pocket, distinct from the enzyme’s active site. We investigated RT–NNRTI interactions ...

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[Report] Structural basis for membrane anchoring of HIV-1 envelope spike

08-Jul-2016 | Jyoti Dev; Donghyun Park; Qingshan Fu; Jia Chen; Heather Jiwon Ha; Fadi Ghantous; Tobias Herrmann; Weiting Chang; Zh ..., Science , 2016

HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used nuclear magnetic resonance to determine an atomic structure of the transmembrane (TM) domain of HIV-1 Env reconstituted in bicelles that mimic a lipid bilayer. The TM forms a well-ordered trimer that ...

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Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses

06-Jul-2016 | Lifeng Fu; Yuhai Bi; Yan Wu; Shanshan Zhang; Jianxun Qi; Yan Li; Xuancheng Lu; Zhenning Zhang; Xun Lv; Jinghua Yan; ..., Journal of Medicinal Chemistry, 2016

Zanamivir and oseltamivir are principal influenza antiviral drugs that target viral neuraminidase (NA), but resistant viruses containing mutant NAs with diminished drug affinity are increasingly emerging. Using the structural knowledge of both drug-binding sites and their spatial arrangement on ...

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HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins [Microbiology]

05-Jul-2016 | Kasia Hrecka; Caili Hao; Ming-Chieh Shun; Sarabpreet Kaur; Selene K. Swanson; Laurence Florens; Michael P. Washburn; ..., Proceedings of the National Academy of Sciences current issue, 2016

HIV replication in nondividing host cells occurs in the presence of high concentrations of noncanonical dUTP, apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated dNTP triphosphohydrolase) dNTPase, which maintains ...

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Native Elution of Yeast Protein Complexes Obtained by Affinity Capture

01-Jul-2016 | LaCava, J., Fernandez-Martinez, J., Rout, M. P., CSH Protocols, 2016

This protocol describes two options for the native (nondenaturing) elution of protein complexes obtained by affinity capture. The first approach involves the elution of complexes purified through a tag that includes a human rhinovirus 3C protease (PreScission protease) cleavage site sequence ...

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