Recombinant Proteins

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News Recombinant Proteins

• Thermo Fisher Scientific Acquires Affinity BioReagents

  Thermo Fisher Scientific Inc. announced that it has acquired Affinity BioReagents, provider of antibodies, peptides, proteins and other reagents for life science research, based in Golden, Colorado. "Affinity BioReagents is an ideal complement to our existing capabilities in protein research," said more

• Eurofins Medigenomix / MWG Biotech sequence Wacker Chemie AG's bacterial protein production strain

  Eurofins Medigenomix GmbH / MWG Biotech AG have finalised a genome sequencing project with Wacker Chemie AG for the analysis of the genetic differences between Wacker's proprietary industrial protein production E. coli strain and its corresponding parental strain. The successful sequencing is an imp more

• Wacker Acquires Pharmaceutical Protein Specialist ProThera

  Effective January 1, 2005, Wacker-Chemie GmbH is taking over German biotech company ProThera GmbH based in Jena. This was announced today by the Munich-based chemical company and ProThera, which will in future operate as Wacker Biotech GmbH. The acquisition expands WACKER's existing custom pharma ma more

White papers Recombinant Proteins

• Increased productivity for downstream processing of biotherapeutics
  

  Polymer-based chromatographic resins featuring high mechanical and chemical stability and high protein binding capacities can help to increase the throughput and robustness of biopharmaceutical manufacturing processes. Advances in genetic engineering and cell culture technology have raised upstream productivity in the production of recombinant proteins. Increased titres of up to 10 g/l stress the need for highly efficient and robust downstream processes (DSP). Most industrial bioprocess development groups apply generic DSP platforms that are designed to purify various candidates of the same class of proteins applying the same process design. Besides various filtration and virus inactivation steps, they usually involve two or three chromatographic unit operations with orthogonal separation modes. The use of high capacity chromatographic resins can help to overcome the DSP bottleneck by increasing process throughput and robustness more

Publications Recombinant Proteins

• Construction of New Ligation-Independent Cloning Vectors for the Expression and Purification of Recombinant Proteins in Silkworms Using BmNPV Bacmid System

  by Tatsuya Kato, James R. Thompson, Enoch Y. Park A ligation independent cloning (LIC) system has been developed to facilitate the rapid and high-efficiency cloning of genes in a Bombyx mori expression system. This system was confirmed by the expression of human microsomal triglyceride transfer p more

• Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus

  The existence of the classical mevalonate (MVA) pathway was examined in the thermoacidophilic archaeon Sulfolobus solfataricus. The pathway is considered uncommon among archaea because the genes of the orthologues of phosphomevalonate kinase (PMK) and/or diphosphomevalonate decarboxylase (DMD) are more

• IJMS, Vol. 14, Pages 8719-8739: Improving Pharmaceutical Protein Production in Oryza sativa

  Application of plant expression systems in the production of recombinant proteins has several advantages, such as low maintenance cost, absence of human pathogens, and possession of complex post-translational glycosylation capabilities. Plants have been successfully used to produce recombinant cytok more

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