Therapeutic Proteins

News Therapeutic Proteins

• Pilot plant for future-oriented technology opens in Halle: Bayer will use tobacco plants to produce medicines

  Medicinal products from plants or even tobacco for health - a vision that could soon become reality. Bayer and its subsidiary Icon Genetics have together developed a new production process that can be used to produce biotech drugs in tobacco plants. A new production facility for therapeutic proteins more

• CMC Acquires Former ICOS Biologics Operation in Bothell, Washington State, USA

  CMC Biopharmaceuticals A/S (CMC) announced that it has reached an agreement to buy the biologics development and manufacturing operation that Eli Lilly and Company acquired when it purchased ICOS Corporation in January 2007. CMC, a Copenhagen based leading provider of contract biomanufacturing servi more

• Emerson wins major contract to digitally automate India's largest life sciences plant

  Emerson Process Management announced that it had won a major contract from Reliance Life Sciences Pvt. Ltd. to supply PlantWeb® digital automation architecture and solution services to their new biopharmaceutical manufacturing facility in India. According to Emerson the new facility is the largest more

White papers Therapeutic Proteins

• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers more

Publications Therapeutic Proteins

• Encapsulation of Milk β-Lactoglobulin by Chitosan Nanoparticles

  Naturally occurring polymers, such as chitosan, have been extensively studied as carriers for therapeutic protein and gene delivery systems. β-Lactoglobulin (β-LG) is a member of the lipocalin superfamily of transporters for small hydrophobic molecules. We examine the binding of milk β-lactoglobulin more

• Molecules, Vol. 18, Pages 5611-5647: Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications

  Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic protei more

• Discovery and Investigation of O-Xylosylation in Engineered Proteins Containing a (GGGGS)n Linker

  Protein engineering is a powerful tool for designing or modifying therapeutic proteins for enhanced efficacy, greater safety, reduced immunogenicity, and better delivery. GGGGS [(G4S)n] linkers are commonly used when engineering a protein, because of their flexibility and resistance to proteases. Ho more

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