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How to Save 80% Costs of Continuous Small Molecule and Biomolecule Purification

Simulated moving bed chromatography (SMBC) for higher productivity and significantly lower costs

How simulated moving bed chromatography (SMBC) works

KNAUER’s AZURA SMB System

Simulated moving bed chromatography (SMBC) is an HPLC technique that continuously separates substance mixtures and extracts them into two fractions. Compared with batch systems, SMBC saves up to 90% of solvent and up to 80% of chromatography column costs. SMB chromatography is typically used for two-component mixtures, from which both substances are directly extracted in pure form. Repeated use of SMB chromatography can also separate multi-component mixtures by separating each fraction into further sub-fractions until a two substance mixture is finally separated into two pure products. SMB chromatography is ideally suited for purifying proteins, sugars, oligosaccharides, amino acids, organic acids, fatty acids and enantiomers on a laboratory or pilot scale.

This white paper tells you more about

  • the basics of SMB chromatography
  • the basic principle of fractionation
  • the purification of small molecules using the example of xylitol
  • the continuous purification of biomolecules
  • the advantages of SMB chromatography over batch processes

The benefits of simulated moving bed chromatography

  • Higher recovery rates and purity of your products
  • Up to 90% lower solvent consumption
  • Up to 80% lower costs for the solid phase
  • Higher productivity than with batch systems
  • Lower pressures due to larger stationary phase particles
  • Scalable from milligrams to kilograms of purified product
  • Continuous process

Download the free white paper now and learn, by studying two typical applications, how simulated moving bed chromatography can significantly reduce the costs of your continuous purification while increasing product yield.

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Facts, background information, dossiers
  • biomolecule purification
  • small molecule purification
  • simulated moving be…
  • xylitol
  • fractionation
  • protein purification
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