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12 Current white paper about the topic molecular weight

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Characterizing Biotherapeutics with HPLC

Smart Solutions for large Molecules

24-11-2010

As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. ...

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Analysis of water soluble polymers using linear size exclusion HPLC columns and a semi-micro SEC system

16-11-2010

One of the most widely used water-soluble polymers is Polyvinylpyrrolidone (PVP). For more than 70 years it is applied in a variety of applications in medicine, pharmacy, cosmetics and industrial production. PVP binds to polar molecules exceptionally well. It supports the solubility of tablets in ...

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Field-Flow Fractionation - The Universal Separation Principle for Particle and Macromolecule Characterization

22-09-2010

High molecular weight polymers, bio molecules or particles in a range of a few nanometers up to several microns are more and more important in science and technology. Many applications are based on the specific properties of these materials. For this reason, an exact knowledge of the molar mass ...

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Absolute Molar Mass Characterisation

27-11-2009

Multi-angle light scattering coupled to SEC or other fractionation methods can provide an absolute means for measuring the molar mass, size and distribution of proteins, polymers and particles of all sorts. Wyatt Technology's MALS also enables the elucidation of additional data such as branching, ...

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New Silicone Technologies for Skin Care

16-11-2009

In today's competitive skin care market, consumers look for a range of benefits, superior aesthetics and cost effectiveness. In response, formulators strive to create products that are multifunctional, easy to use and effective in small quantities. At the same time, the most successful products ...

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Asymmetric Flow Field Flow Fractionation (AF4) - A Powerful Method for Polymer Characterization

05-11-2009

The AF4-MALS combined technique can serve as a routine method for polymer analysis and characterization. AF4 provides separation efficiency entirely comparable with traditionally used and so far dominating SEC. In addition, it yields superior separation of branched polymers, polymers containing ...

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Bearing grease selection

03-09-2009

Rolling-element bearings are used for the precise guidance of moving parts. Frictional losses are extremely small because the bearings rest on rolling elements, enabling very heavy loads to be adsorbed. Rolling-element bearings may be lubricated with greases or oils depending on the point of use. ...

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Polyolefins: Determination of Molecular Weight and Branching Structure by GPC/SEC

16-06-2008

Polyethylene and Polypropylene are so-called Polyolefins. They are produced in large amounts every year. Depending on the process and catalyst used linear or branched polymers can be produced. In case of e. g. Polyethylene there are at least three polymer types: HDPE (High Density Polytheylene), ...

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Measurement of Nano particles and Proteins

08-11-2006

Colloid emulsions in their native environment require particle size determination in high concentration since there are concerns about changes in sample morphology upon dilution eg break up of aggregates. For proteins and other samples with very low concentration and for weakly scattering samples ...

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"Triple Detection" in Gel Permeation Chromatography

11-11-2005

Gel permeation chromatography (GPC) or also named size exclusion chromatography (SEC) is the most often used method for determining the molecular weight of natural and synthetic macromolecules. One specific strength of this method lies in the fact that by the separation process the whole ...

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