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4 Current white paper about the topic water

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Analysis of water soluble polymers using linear size exclusion HPLC columns and a semi-micro SEC system

16-11-2010

One of the most widely used water-soluble polymers is Polyvinylpyrrolidone (PVP). For more than 70 years it is applied in a variety of applications in medicine, pharmacy, cosmetics and industrial production. PVP binds to polar molecules exceptionally well. It supports the solubility of tablets in water, makes the glue stick adhesive and plays an essential role in the production of membranes. In ceramic, paper and dye applications, it produces visual effects such as gloss and brilliancy. As a food additive, PVP is a stabilizer (E1201). A characteristic feature of a certain polymer is its molecular weight distribution curve, which is usually obtained by SEC Analysis...

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Size and element specific determination of Ag nanoparticles in consumer spray products using asymmetric flow field flow fractionation (AF4) coupled to ICPMS

10-09-2010

The use of nanoparticles in consumer products shows a tremendous increase over the past years. A study of the Woodrow Wilson International Centre for Scholars reported that between 2005 and today the number of products based on nanoparticles increased almost twentyfold from 54 to 1015. As active compounds these products contain ZnO for surface protection, TiO2 for sun screen or Ag for anti-bacterial purposes, only to name a few applications. Furthermore, Si, C and Au are frequently used. So far, no data are available concerning the release and the behaviour of nanoparticles during the spray process. Therefore, in spite of their beneficial properties, possible risks for humans and the environment need to be thoroughly investigated. Especially the exposure pathway via the lung seems to be very critical, as could be shown in a study recently published in the Journal of Nanoparticle Research...

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Automated Dynamic Light Scattering

09-11-2009

DLS analysis is a widely applied, non-invasive method for measuring the effective size of molecules in solution. This technique yields valuable information for the characterization of molecules and particles. It facilitates formerly laborious and time consuming measurements, e.g. screening for aggregates or determining optimal crystallization conditions for proteins. The Wyatt Plate Reader is the instrument of choice for any application where molecular size, stability and aggregation are of interest. It reads industry standard microplates with up to 1536 samples automatically and temperature-controlled, if desired. The applications of the technique are wide ranging and include many of the fastest growing areas of research - proteins, biomaterials, liposomes and micelles as well as the established uses for particle sizing and aggregation detection. Conscious of the numerous characterization challenges in the area of drug delivery systems and therapeutic antibodies...

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Accurate Mass and TIPTM: Two Dimensions for Elemental Composition Determination: microTOFTM Featuring Unique TIPTM

10-03-2005

The ESI-TOF mass spectrometers micrOTOF and micrOTOF focus do not only provide accurate mass measurements but additionally describe the True Isotopic Pattern TIPTM. For molecular formula generation this unique combination significantly reduces the number of possible formula candidates and the elemental composition of compounds with molecular weights far higher than 500 Da can unequivocally be determined...

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