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6 Current white paper about the topic waterrss
In the Life Sciences and Bio-medical Research, the characterization of chemical compounds within cells or tissues is one of the most important and difficult tasks for researchers to perform. The development of pharmaceuticals such as drug delivery coatings or capsules also requires as much information as possible about their chemical and structural compositions. For the fields of nanotechnology and materials science, a thorough knowledge of the samples' surface morphology on a sub-micron scale is essential...
DLS analysis is a widely applied, non-invasive method for measuring the effective size of molecules in solution. This technique yields valuable information for the characterization of molecules and particles. It facilitates formerly laborious and time consuming measurements, e.g. screening for aggregates or determining optimal crystallization conditions for proteins. The Wyatt Plate Reader is the instrument of choice for any application where molecular size, stability and aggregation are of interest. It reads industry standard microplates with up to 1536 samples automatically and temperature-controlled, if desired. The applications of the technique are wide ranging and include many of the fastest growing areas of research - proteins, biomaterials, liposomes and micelles as well as the established uses for particle sizing and aggregation detection. Conscious of the numerous characterization challenges in the area of drug delivery systems and therapeutic antibodies...
Dynamic Light Scattering (DLS) is an established technique in the field of protein crystallography. DLS is used to measure hydrodynamic sizes, polydispersities and aggregation effects of protein samples. These are important parameters for the crystallisation of proteins. DLS is also used in the nanotechnology research for the accurate and fast size measurement of nanoparticles made of different materials....
Within nearly all branches of industry we find products, which are coated with thin transparent layers to improve the surface features: Window sheet glasses obtain changes in reflection and absorption behavior, ceramics are treated with coatings to lower water adhesion, coatings on metals create corrosion resistance or better sliding factors. Transparent coatings play also a major role in the semiconductor business. One of the important features to be determined and controlled is the thickness of the layers to balance performance and material input during development and production...
The ESI-TOF mass spectrometers micrOTOF and micrOTOF focus do not only provide accurate mass measurements but additionally describe the True Isotopic Pattern TIPTM. For molecular formula generation this unique combination significantly reduces the number of possible formula candidates and the elemental composition of compounds with molecular weights far higher than 500 Da can unequivocally be determined...
Microwave-assisted organic synthesis (MAOS) has become an increasingly popular discipline in modern chemical method development. At first, reaction optimization and method development on a small scale were the main areas of interest in MAOS. However, the growing acceptance and success of this innovative microwave technology revealed the necessity for large-scale synthesis of valuable compounds using microwave heating, especially in industrial laboratories...