Staff working in areas ranging from research to production. The modular structure of the course allows the participants to request their own topics as well.
Objectives
The participants will acquire state-of-the-art knowledge about GMP-compliant processing using crossflow filtration.
Course content
Theoretical Section:
* Crossflow filtration theory * Membrane characterization | membrane selection * Factors critical to performance * Scaling up * Operating conditions * Cleaning-in-place (CIP) * Steaming-in-place (SIP) * Integrity testing * Applications in biotechnology
Practical Section:
* Operational set-up of the systems * Determining the flux rate for water * Demonstration of steaming in place (optional) * Cell (particle) retention by Microfiltration (model solution) * Concentration of protein solutions by ultrafiltration * Removal of low-molecular weight constituents by diafiltration * Cleaning * Discussion of the results
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