C3 (complement)
| Complement component 3
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| PDB rendering based on 1c3d.
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| Available structures: 1c3d, 1ghq, 1w2s, 2a73, 2a74, 2b39, 2gox, 2hr0, 2i07, 2ice, 2icf
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| Identifiers
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| Symbol(s)
| C3; ASP; CPAMD1
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| External IDs
| OMIM: 120700 MGI: 88227 Homologene: 68031
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| Gene Ontology
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| Molecular Function:
| • endopeptidase inhibitor activity
• receptor binding
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| Cellular Component:
| • extracellular region
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| Biological Process:
| • inflammatory response
• complement activation, alternative pathway
• complement activation, classical pathway
• signal transduction
• G-protein coupled receptor protein signaling pathway
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| Orthologs
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| Human
| Mouse
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| Entrez
| 718
| 12266
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| Ensembl
| na
| ENSMUSG00000024164
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| Uniprot
| na
| Q207D2
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| Refseq
| NM_000064 (mRNA)
NP_000055 (protein)
| NM_009778 (mRNA)
NP_033908 (protein)
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| Location
| na
| Chr 17: 56.89 - 56.91 Mb
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| Pubmed search
| [1]
| [2]
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In immunology, soluble C3-convertase, also known as iC3Bb, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the alternative complement system.
C3a
C3a plays an important role in chemotaxis, though not as important a role as C5a.[1]
It is also an anaphylatoxin.
C3b
C3b may bind to microbial cell surfaces within an organism's body. This can lead to the production of surface-bound C3 convertase and thus more C3b components. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound.
Alternatively, bound C3b may aid in opsonization of the microbe by macrophages.[1] Complement receptor 1 or CR1 on macrophages allows the engaging of C3b covered microbes.
C3b is cleaved into C3c and C3d.
See also
References
- ^ a b Immunology at MCG 1/phagocyt
Further reading
- Matsuyama W, Nakagawa M, Takashima H, et al. (2002). "Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters.". Intern. Med. 40 (12): 1254-8. PMID 11813855.
| Proteins: complement system (C, L, A) |
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| Activators | CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin |
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| Enzymes | C: C1Q/C1R/C1S - C4 (A) - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D |
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| Inhibitors | CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H |
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| Complement receptors | CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a) |
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