R-type calcium channel
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calcium channel, voltage-dependent, R type, alpha 1E subunit
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| Identifiers |
| Symbol |
CACNA1E |
| Alt. Symbols |
CACNL1A6 |
| Entrez |
777 |
| HUGO |
1392 |
| OMIM |
601013 |
| RefSeq |
NM_000721 |
| UniProt |
Q15878 |
| Other data |
| Locus |
Chr. 1 q25-q31 |
The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.
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Membrane transport protein: ion channels |
| Ca2+: Calcium channel |
Voltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel |
| Na+: Sodium channel |
Navα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Navβ (1, 3, 4) • Epithelial sodium channel |
| K+: Potassium channel |
Voltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9) |
| Cl-: Chloride channel |
Cystic fibrosis transmembrane conductance regulator |
| Porin |
Aquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1) |
| Cations: TRP |
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6) |
| Other/general |
Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel |
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