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Optimized Fermentation process due to new electro optical signal
EloTrace detects the metabolic status of bacteria cells on-line
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Optimization of fermentation process was always a trial and error process. With the world novelty EloTrace you can get directly information of the metabolic status of the cell in vivo. Now it is possible to witness the cell viability online. The innovation prize winner
EloTrace combines sample taking and sample preparation and measures 3 essential parameters: metabolic status, cell size and optical density.
For the first time you can assess all these parameters online for bacterial fermentations without time and cost consuming offline analysis. EloTrace makes it possible to check and control the fermentation process to achieve an optimal fermentation process. Necessary interferences like temperature change, pH change, feeding of additional substances can be performed to optimize the result.
Furthermore the continuous online documentation can be used for Quality control and is congruent with the PAT initiative (Process Analytical Technology) of the FDA. No chemicals are needed. The intelligent software makes the use easy.
The advantages of EloTrace at a glance:
- Determination of cell activity, stress levels, cell size and morphological changes
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Prediction of culture development
- Prediction of points in time with higher cell vitality and productivity
- Selection of optimal set points for inoculation, induction and harvest
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Areas of applications:
- Production of recombinant proteins and other biosubstances
- Production of vaccines
- Production of starter cultures, probiotic and competent cells
- Quality assurance and process validation of fermentations
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The control the amino acid content of fermentation media can be double checked with our Amino Acid Analyzer Aracus. This system combines innovative technology with the classical gold standard of post column derivatization. The Aracus has high reproducibility (RSD <1% in time and <3% in area), is easy to use and very cost efficient.
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Additional information
membraPure GmbH
Bodenheim, Germany
Company
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