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ZIC®-HILIC - Better separation of polar compounds ZIC®-HILIC HPLC columns now available from Merck

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Reversed-phase chromatography is the most widely used technology in HPLC. Nevertheless, when analyzing polar and hydrophilic compounds such as amines, organic acids, amino acids or ionic compounds it has severe limitations because these compounds often have little or no retention on reversed-phase columns. The solution: ZIC®HILIC – a unique zwitterionic HILIC (hydrophilic interaction liquid chromatography) separation technique developed by SeQuant and now available from Merck.

Using the innovative Merck SeQuant ZIC®HILIC technology, all types of polar and hydrophilic compounds can be separated – from small peptides to ions, from complex carbohydrates to metabolites. Based on a stationary phase with a covalently bonded, highly polar zwitterionic functional group, ZIC®HILIC HPLC columns provide higher stability and more robust HILIC separations than conventional silica, amino-phases or diol-phases, thereby also reducing cost per analysis. In addition, the high organic mobile phase provides better desolvation and ionization conditions and the sensitivity for LC/MS is considerably enhanced. The Food and Drug Administration (FDA) recently published a method for the determination of melamine and cyanuric acid using the SeQuant ZIC®HILIC separation technolgy.

Because of its striking advantages compared to other HILIC techniques, Merck SeQuant ZIC®-HILIC is considered the “gold standard” in HILIC separations.

Merck SeQuant ZIC®-HILIC HPLC columns are available packed with either 3 or 5 µm particles and in various formats from classical analytical and capillary columns to preparative dimensions.

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