To use all functions of this page, please activate cookies in your browser.
High sensitivity, durability and ease-of-use
In pharmaceutical development analysis occasionally has to be performed on only trace amounts of components in small blood samples. Examples include studies of the pharmacokinetics of new drug substances or their metabolism. In such cases, LC-MS systems compatible with nano flowrates have been utilized. However, nano flowrate-compatible LC-MS systems often suffer from complications in terms of instrument operability and processing speed, such as a tendency for pipes to clog, difficulty discovering liquid leaks and the hours required for the analysis of a single sample.
The Nexera Mikros can accommodate a wide range of flowrates, from semi-micro flowrates (100 to 500 µL/min), to micro flowrates (1 to 10 µL/min). With this product, Shimadzu is contributing to improving the productivity at pharmaceutical companies and clinical contract research organizations.
Specific features are:
1. Significant increase in sensitivity
Nexera Mikros is equipped with e newly developed solvent delivery pump including a control system that reduces pulsation and delivers a stable solvent flow even at low micro flowrates. In addition, the positioning of the ionization interface has been optimized for more efficient sample introduction into the mass spectrometer.
2. UF-Link technology supports high-sensitivity analysis and improved operability
Microscopic gaps (dead volume) in the piping connectors lead to a decrease in sensitivity by causing peak dispersion. UF-Link, a connection mechanism between the analytical column and the mass spectrometer, enables one-touch, zero-dead-volume connection between the column and the ionization interface of the mass spectrometer. UF-Link is compatible any standard column, offering a flexible choice of stationary phases to suit the target sample.
3. Higher efficiency of investments in Research and Development
The LC-Mikros solvent delivery pump serves a wide flowrate range, from micro flowrates of 1 µL/min to semi-micro flowrates of 500 µL/min. By enabling analysis comparable to existing LC-MS systems, as well as high-sensitivity analysis at micro flowrates, this single unit improves the operational efficiency of the LC-MS system and shortens research and development times.
micro LC systems
Shimadzu's new UV-1900 UV-VIS spectrophotometer is equipped with an ultrafast scan function that enables data acquisition in 29,000nm/min (it takes about three seconds to measure in visible region.), the fastest level in the industry. The UV-1900 features a large, easy-to-use color touch pa ... more
Shimadzu has joined forces with the France-based AlsaChim company, an independent contract research and development organization. AlsaChim specializes in stable isotope-labelled compounds, metabolites and pharmaceutical related substances, and analytical purposes. With immediate effect, Shi ... more
Shimadzu announces the completion of the new Quality Center building, which has been under construction at its head office (Sanjo Works) premises since February 2013. The Quality Center has been constructed to improve the quality of products developed and manufactured by Shimadzu. It consol ... more
Shimadzu has created a new Laboratory World for its customers from all over Europe. The Laboratory World is located at Shimadzu’s European headquarters in Duisburg, Germany. On an area greater than 1,500 m2, testing facilities are available for Shimadzu’s entire product range – from chromat ... more
Our experience with sugar starts in early childhood – since breast milk contains lactose. Human sensory perception alone is, however, not enough more
The determination of algal biomass using TOC is a new method that has proven to be highly suitable in a laboratory environment for the measurement of biomass more
Shimadzu is a world-leading manufacturer of analytical instrumentation. Shimadzu develops and manufactures innovative products for laboratories in industry, science and governmental institutions. With our customer-oriented strategy and our high-quality service, we strive to be Europe's mark ... more
Shimadzu is a world leader in instrumental analysis. Shimadzu develops and produces innovative products for laboratories in industry, science and institutions. We want to be a leader in all European markets with our customer-oriented strategy and our highly qualified services. We offer nume ... more
Shimadzu provides a broad range of analytical instruments indispensable for research, development, and quality control in a variety of fields. Our high-level, sophisticated instruments include chromatographs, spectrometers, and elemental and surface analysis systems. We also provide a broad ... more
- 1Most Advanced HPLC Systems with Excellent Retention Time Stability and Precision
- 2New Thermo Scientific Orbitrap Exploris Mass Spectrometry Systems
- 3New SPE material for liquid AND gas chromatography
- 4The Gold Standard in GC-MS for Sensitive, Specific Quantitation of Target Compounds
- 5Confident quantitation with triple quadrupole LC-MS systems
- 6Perform like a PRO in elemental analysis and experience simplicity, robustness and speed in ICP-OES
- 7Be a Pioneer – the Freedom to Explore Ion Chromatography
- 8Automate Your Environmental, Water, Detergent, Food and Beverage Analysis
- 9Neoma™ Multicollector ICP-MS - Technology that transforms your science
- 10High-Pressure Ion Chromatography (HPIC) with Top Resolution at Its Fastest