Buchwald Ligands and Precatalysts for Cross-coupling Reactions

Learn to choose the correct combination of the ligand, palladium source and reaction conditions

Cross-coupling reactions are powerful tools that enable the formation of bonds between two molecular fragments utilizing a catalyst system. These reactions are routinely performed by chemists in academia and industry at scales ranging from bench to bulk. The cross-coupling methodology has become indispensable for modern chemistry for the efficient synthesis and scale-up of building blocks, flavors and fragrances, active pharmaceutical ingredients, OLEDs, and polymers as well as protein modification, and isotope labeling. The revolutionary significance of cross-coupling reactions was acknowledged with the Nobel Prize in Chemistry, which was jointly awarded to Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki in 2010 for palladium-catalyzed cross couplings in organic synthesis. This application guide provides an overview of Buchwald ligands, precatalysts and related phosphine ligands for cross-coupling reactions.

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  • Cross-coupling reactions

  • palladium catalysts

  • cross-coupling reactions

  • cross-coupling reactions

  • catalysts

  • Buchwald Ligands

  • Buchwald Precatalyst

  • Phosphine Ligands

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