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Science of Synthesis is your one-stop tool for full-text reviews of organic transformations and experimental procedures. The online reference work helps speed up your literature research and improve your strategy for the design of new molecules.
Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to-date for the entire field of organic and organometallic chemistry.
Methods Selected, Reviewed and Continually Updated by 1,750 Experts
World-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. They update the content regularly with new information and special topics of particular interest to the synthetic chemist.
Immediately Applicable in the Lab
Effective and practical experimental procedures can also be implemented quickly and easily in the lab. This enables the chemist to get started immediately with the design and planning of a synthesis.
Highlighting Special Fields – the Reference Library
The Reference Library features the best methods in special fields of importance in organic synthesis, like Asymmetric Organocatalysis, Stereoselective Synthesis, Cross Coupling and Heck-Type Reactions, Water in Organic Synthesis, C-1 Building Blocks und Multicomponent Reactions.
Why Use Science of Synthesis?
Science of Synthesis is essential in helping you complete the design of your synthetic strategy after you have collected together relevant citations, patent and property information. It helps you answer questions such as:
Recommended by Leading Experts
"In a world where information, or data, has become trivial to access anywhere, all the time, it is important to reflect on the words of Einstein 'Information is not knowledge.' Science of Synthesis is the furnace through which information is forged into high quality knowledge-based principles that allow practicing scientists to make learned, enabling decisions. It is the tool which one can deploy to do great science."
Prof. Erick M. Carreira, ETH Zurich, Switzerland
Science of Synthesis not only provides data but in depth scientific context. It is a highly valuable, well reviewed and comprehensive source of knowledge for relevant topics in synthesis. Access to the content of Science of Synthesis should result in a better understanding of state of the art methodology and therefore is enabling high quality research in synthesis.
Dr. Guido Koch, Novartis Institutes for BioMedical Research
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Science of Synthesis is your one-stop tool for full-text reviews of organic transformations and experimental procedures. The online reference work helps speed up your literature research and improve your strategy for the design of new molecules. Science of Synthesis provides a critical revi ... more
SynlettDOI: 10.1055/s-0036-1589038 A radical–radical cross-coupling reaction of phenols with tert-butyl nitrite has been developed with the use of water as an additive. This method allows the construction of C–N bonds under an air atmosphere at room temperature, providing the ortho-nitrate ... more
SynlettDOI: 10.1055/s-0036-1588863 We report here our latest discovery on the directed lithiation and palladium-catalyzed arylation of anisoles. During this research, the formation of a four-membered lithiumcycle followed by transmetalation to the corresponding palladacycle has been achiev ... more
SynlettDOI: 10.1055/s-0036-1588455 The biaryl unit containing a heteroatom is a key structure in a large number of natural products and π-conjugated organic systems. The cross-couplings can provide powerful methods for the construction of biaryls and heterobiaryls; thus the development of ... more
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