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RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif [Biochemistry]

RNA polymerase II (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, DNA lesions, and nucleosomes. Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with programmable sequence specificity and high affinity. Previous studies suggest that Py-Im polyamides can prevent transcription factor binding, as well as...

Authors:   Liang Xu; Wei Wang; Deanna Gotte; Fei Yang; Alissa A. Hare; Timothy R. Welch; Benjamin C. Li; Ji Hyun Shin; Jenny Chong; Jeffrey N. Strathern; Peter B. Dervan; Dong Wang
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   113
edition:   44
Year:   2016
Pages:   12426
DOI:   10.1073/pnas.1612745113
Publication date:   01-Nov-2016
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