my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
Abstract: By the developmentof new antineoplastic drugs addressed tospecific sites (key to tumor growth), targeted agents, which do not interfere with most normal cells have many advantages like fewer side effects (as personalized treatment), and prolonged survival time of cancer patients compared to conventional therapy. As current approaches in cancer therapy, drug delivery systems based on polymers (synthetic, natural or combinations like micelles, nanospheres, nanocapsules, nanogels, polymer-drug conjugates, polymer-drug polyplex, polymersomes) are more benefic compared to parent free drug, because of targeted effect of delivery, low toxicity, solubility in biological fluids and immunostimulatory effects. Synthetic polymers (polyesters, polyamides and polyethers) are the most used core materials for drug delivery systems, many of them being officially certified. On the other hand due to their better biocompatibility and biodegradability, the natural ones (polysaccharides and proteins) are still a hot topic on cancer therapy as drug delivery and targeting materials. This article reviews the multifunctional materials used in targeting of drugs with polymer based delivery systems as current-day data and key of future applications on cancer therapy. An increasing interest in the last decades returns to the new, engineered inorganic materials as well as to the newly optimized composites and nanocomposites.
| Authors: | Yipel, Mustafa; V. Ghica, Mihaela; G. Albu Kaya, Madalina; Spoiala, Angela; Radulescu, Marius; Ficai, Denisa; Ficai, Anton; Bleotu, Coralia; Cornelia, Nitipir | |
| Journal: | Organic Chemistry |
Abstract: Background: Azocalix[4] arene derivative based on 2,6-diamino pyridine has been synthesized from diazo-coupling reaction between tetradiazonium salt of calix[4]arene and 2,6-diaminopyridine, and characterized by various spectroscopic methods such as IR, 1HNMR, 13CNMR and Mass spe ... more
MSD-MAP: A Network-Based Systems Biology Platform for Predicting Disease-Metabolite Links
Abstract: Background: Cancer-associated metabolites result from cell-wide mechanisms of dysregulation. The field of metabolomics has sought to identify these aberrant metabolites as disease biomarkers, clues to understanding disease mechanisms, or even as therapeutic agents. Objective: Thi ... more
Antimalarials: Molecular Drug Targets and Mechanism of Action
Abstract: Background: Despite a reduction in the global burden of malaria, the disease remains responsible for 214 million cases and 438,000 deaths annually with 88% of the mortality occurring in sub-Saharan Africa. Malaria control largely depends on effective chemotherapy. However, the hi ... more
Synthesis of medicinally privileged heterocycles through dielectric heating
Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twent ... more
A new breakthrough in the synthesis of chiral 3,6-Dihydro-2H-pyrans
The pyran ring is present in so many useful compounds, such as pharmaceuticals (antibiotics, anti-infectives, cardiovascular agents, neurological modulators, anti-allergic, anti-asthmatic, anti-inflammatory agents, reproductive and genitourinary agents, growth promoters and antidiabetic age ... more
Read what you need to know about our industry portal chemeurope.com.
© 1997-2022 LUMITOS AG, All rights reserved
