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Plug-Volume-Modulated Dilution Generator for Flask-Free Chemistry

Dilution is one of the common chemical procedures which are carried out in all chemistry laboratories—to prepare standard solutions with different concentrations for assay calibration, and to reduce matrix effects while handling complex samples. Yet dilution is mostly performed manually using large-volume manual liquid-handling tools (volumetric flasks, graduated cylinders, and pipettes). Here we describe a simple continuous and automated method of diluting complex samples and stock solutions using an Arduino-based control unit. The proposed plug-volume-modulation approach relies on continuous introduction of short plugs of samples separated with short plugs of solvent. The train of sample pulses is generated by opening and closing two pinch valves interchangeably, so that either sample or solvent can enter the mixing zone (T-junction). The plugs of sample and solvent are pulled along a transfer flow line by a peristaltic pump. They mix due to advection, turbulence, and diffusion. The effluent of the flow...

Authors:   Pei-Han Liu; Pawel L. Urban
Journal:   Analytical Chemistry
Year:   2016
DOI:   10.1021/acs.analchem.6b03244
Publication date:   15-Nov-2016
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