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Synthetic genome readers target clustered binding sites across diverse chromatin states [Biochemistry]

Targeting the genome with sequence-specific DNA-binding molecules is a major goal at the interface of chemistry, biology, and precision medicine. Polyamides, composed of N-methylpyrrole and N-methylimidazole monomers, are a class of synthetic molecules that can be rationally designed to “read” specific DNA sequences. However, the impact of different chromatin states...

Authors:   Graham S. Erwin; Matthew P. Grieshop; Devesh Bhimsaria; Truman J. Do; José A. Rodríguez-Martínez; Charu Mehta; Kanika Khanna; Scott A. Swanson; Ron Stewart; James A. Thomson; Parameswaran Ramanathan; Aseem Z. Ansari
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   113
edition:   47
Year:   2016
Pages:   E7418
DOI:   10.1073/pnas.1604847113
Publication date:   22-Nov-2016
Facts, background information, dossiers
  • chromatin
  • DNA
  • precision medicine
More about Proceedings of the National Academy of Sciences
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