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Ultrasensitive Surface-Enhanced Raman Scattering Sensor of Gaseous Aldehydes as Biomarkers of Lung Cancer on Dendritic Ag Nanocrystals

Surface-enhanced Raman scattering (SERS) is expected as a technique that even theoretically detected chemicals at the single molecule level by surface plasmon phenomena of noble metal nanostructures. Insensitivity of detecting Raman weak-intensity molecules and low adsorptivity of gaseous molecules on solid substrates are two main factors hindering the application of SERS in gas detectors. In this manuscript, we demonstrated an operational SERS strategy to detect gaseous Raman weak-intensity aldehydes that have been considered as a biomarker of lung cancer for abnormal content was measured in volatile organic compounds (VOCs) of lung cancer patients. To enhance the adsorption of gaseous molecules, dendritic Ag nanocrystals mimicking the structural feature (dendritic) of moth’s antennae were formed, wherein the existence of numerous cavity traps in Ag dendritic nanocrystals prolonged reaction time of the gaseous molecules on the surface of solid surface through the “cavity-vortex” effect. By the nucleophil...

Authors:   Zhen Zhang; Wei Yu; Jing Wang; Dan Luo; Xuezhi Qiao; Xiaoyun Qin; Tie Wang
Journal:   Analytical Chemistry
Year:   2017
DOI:   10.1021/acs.analchem.6b05117
Publication date:   13-Jan-2017
Facts, background information, dossiers
  • aldehydes
  • Vortex
  • volatile organic compounds
  • substrates
  • Single
  • scattering
  • biomarkers
  • biomarker
  • adsorption
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