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The mechanisms by which pathogens sense the host and respond by remodeling gene expression are poorly understood. Enteropathogenic Escherichia coli (EPEC), the cause of severe intestinal infection, employs a type III secretion system (T3SS) to inject effector proteins into intestinal epithelial cells. These effectors subvert host cell processes to promote bacterial colonization. We show that the T3SS also functions to sense the host cell and to trigger in response posttranscriptional remodeling of gene expression in the bacteria. We further show that upon effector injection, the effector-bound chaperone (CesT), which remains in the EPEC cytoplasm, antagonizes the posttranscriptional regulator CsrA. The CesT-CsrA interaction provokes reprogramming of expression of virulence and metabolic genes. This regulation is likely required for the pathogen’s adaptation to life on the epithelium surface. Authors: Naama Katsowich, Netanel Elbaz, Ritesh Ranjan Pal, Erez Mills, Simi Kobi, Tamar Kahan, Ilan Rosenshine
| Authors: | Naama Katsowich; Netanel Elbaz; Ritesh Ranjan Pal; Erez Mills; Simi Kobi; Tamar Kahan; Ilan Rosenshine | |
| Journal: | Science | |
| Volume: | 355 | |
| edition: | 6326 | |
| Year: | 2017 | |
| Pages: | 735 | |
| DOI: | 10.1126/science.aah4886 | |
| Publication date: | 17-Feb-2017 |
Random number generators go public
On 10 July, researchers in Chile will unveil an online public random number service. Later in July, the U.S. National Institute of Standards and Technology (NIST) will launch its Randomness Beacon as a permanent service, upgrading a pilot program that began in 2013. Brazil, too, is planning ... more
When the cure kills—CBD limits biodiversity research
The Convention on Biological Diversity (CBD) commits its 196 nation parties to conserve biological diversity, use its components sustainably, and share fairly and equitably the benefits from the utilization of genetic resources. The last of these objectives was further codified in the Conve ... more
See-through solar cells could power offices
Solar windows turn some of the light shining through into electricity. They've been on the market for years. But many of these windows absorb some visible light, leaving them with a reddish or brownish hue, a trait frowned on by architects. Now, new versions are on the way that absorb invis ... more
Researchers have developed a compound that can transform near-infrared light into broadband white-light, offering a cheap, efficient means to produce visible light. The emitted light is also exceedingly directional, a desirable quality for devices like microscopes that require high spatial ... more
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