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[Report] Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria

The mechanisms by which pathogens sense the host and respond by remodeling gene expression are poorly understood. Enteropathogenic Escherichia coli (EPEC), the cause of severe intestinal infection, employs a type III secretion system (T3SS) to inject effector proteins into intestinal epithelial cells. These effectors subvert host cell processes to promote bacterial colonization. We show that the T3SS also functions to sense the host cell and to trigger in response posttranscriptional remodeling of gene expression in the bacteria. We further show that upon effector injection, the effector-bound chaperone (CesT), which remains in the EPEC cytoplasm, antagonizes the posttranscriptional regulator CsrA. The CesT-CsrA interaction provokes reprogramming of expression of virulence and metabolic genes. This regulation is likely required for the pathogen’s adaptation to life on the epithelium surface. Authors: Naama Katsowich, Netanel Elbaz, Ritesh Ranjan Pal, Erez Mills, Simi Kobi, Tamar Kahan, Ilan Rosenshine

Authors:   Naama Katsowich; Netanel Elbaz; Ritesh Ranjan Pal; Erez Mills; Simi Kobi; Tamar Kahan; Ilan Rosenshine
Journal:   Science
Volume:   355
edition:   6326
Year:   2017
Pages:   735
DOI:   10.1126/science.aah4886
Publication date:   17-Feb-2017
Facts, background information, dossiers
  • gene expression
  • bacteria
  • proteins
  • Expression
  • epithelial cells
  • enteropathogenic Es…
  • cytoplasm
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