my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
Abstract
Die dreidimensionale Struktur des Metallothioneins (MT) der Großen Strandschnecke (Littorina littorea), LlMT, im Komplex mit Cd2+‐Ionen wurde NMR‐spektroskopisch aufgeklärt. Das LlMT ist imstande, neun Zn2+‐ oder neun Cd2+‐Ionen zu binden. Sequenz‐Alignments mit MTs anderer Gastropoden lassen darauf schließen, dass das Protein wahrscheinlich aus drei Domänen aufgebaut ist. Das Protein ist in drei Einzeldomänen unterteilt, von denen jede eine gut definierte Faltung in Form eines Drei‐Metall‐Clusters annimmt. Die mittlere α2‐ und die C‐terminale β‐Domäne sind zueinander in einer definierten relativen Orientierung positioniert. Zwei Varianten des LlMT, mit einem längeren und einem kürzeren Linker, wurden ebenfalls untersucht; die spezifischen Kontakte zwischen den Domänen traten nur im Fall des Wildtyp‐Linkers auf. Eine weitere Mutante, bei der die einander sehr ähnlichen α1‐ und α2‐Domänen miteinander vertauscht wurden, zeigte eine fast identische Struktur zum Wildtyp‐MT. Die Expression eines Drei‐Domänen‐MT könnte Littorina littorea einen evolutionären Vorteil bei der Bewältigung von Cd2+‐Stress und widrigen Umweltbedingungen verleihen.
Gute Schwermetalltoleranz: Metallothioneine sind kleine Proteine, die Schwermetalle über Cys‐Reste binden und so charakteristische Metallcluster bilden können (siehe Struktur). Das Metallothionein der Schnecke Littorina Littorea zeigt eine neuartige Drei‐Domänen‐Struktur, die seine Metallbindungskapazität erhöht. Dieses biologisch bedeutsame Merkmal könnte dem Organismus helfen, in Schwermetall‐verschmutzten Umgebungen zu überleben.
| Authors: | Christian Baumann, Andrea Beil, Simon Jurt, Michael Niederwanger, Oscar Palacios, Mercè Capdevila, Sílvia Atrian, Reinhard Dallinger, Oliver Zerbe | |
| Journal: | Angewandte Chemie | |
| Year: | 2017 | |
| Pages: | n/a | |
| DOI: | 10.1002/ange.201611873 | |
| Publication date: | 23-Mar-2017 |
Fluorescence usually entails the conversion of light at shorter wavelengths to light at longer wavelengths. Scientists have now discovered a chromophore system that goes the other way around. When excited by visible light, the fluorescent dyes emit light in the ultraviolet region. According ... more
Metal-ion hybrid capacitors combine the properties of capacitors and batteries. One electrode uses the capacitive mechanism, the other the battery-type redox processes. Scientists have now scrutinized the role of anions in the electrolyte. The results, which have been published in the journ ... more
Well oriented: Catalysts for isotactic polar polypropylenes
Polypropylene (PP) is one of the most widely used plastics in the world. By controlling the spatial orientation of the propylene building blocks and additional polar components, it should be possible to create a new generation of attractive, engineered, specialty plastics, with improved wet ... more
The unfolding landscape of the congenital myasthenic syndromes
Abstract Congenital myasthenic syndromes (CMS) are heterogeneous disorders in which the safety margin of neuromuscular transmission is impaired by one or more specific mechanisms. Since the advent of next‐generation sequencing methods, the discovery of novel CMS targets and phenotypes ha ... more
Passive transfer models of myasthenia gravis with muscle‐specific kinase antibodies
Abstract Myasthenia gravis (MG) with antibodies to muscle‐specific kinase (MuSK) is characterized by fluctuating fatigable weakness. In MuSK MG, involvement of bulbar muscles, neck, and shoulder and respiratory weakness are more prominent than in acetylcholine receptor (AChR) MG. MuSK au ... more
Abstract Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessme ... more
Smart skin made of recyclable materials may transform medicine and robotics
Smart skin that can respond to external stimuli could have important applications in medicine and robotics. Using only items found in a typical household, researchers have created multi-sensor artificial skin that's capable of sensing pressure, temperature, humidity, proximity, pH, and air ... more
How mercury contamination affects reptiles in the Amazon basin
Mercury contamination in water and on land is of worldwide concern due to its toxic effects on ecosystems and human health. Mercury toxicity is of particular concern to reptiles because they are currently experiencing population declines. Also, reptiles are ideal indicators of mercury conta ... more
Bioengineers Succeed in Producing Plastic Without the use of Fossil Fuels
A team of pioneering South Korean scientists have succeeded in producing the polymers used for everyday plastics through bioengineering, rather than through the use of fossil fuel based chemicals. This groundbreaking research, which may now allow for the production of environmentally consci ... more
Read what you need to know about our industry portal chemeurope.com.
© 1997-2021 LUMITOS AG, All rights reserved
