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Abstract BACKGROUND
Succinic acid (SA) biotechnological production represents a promising alternative to the fossil‐fuel based chemical production route. The goal of this study was to develop a SA production process conducted with biofilms of Actinobacillus succinogenes and fed with cheese whey, a lactose‐rich by‐product of the cheese‐making processes.
RESULTSThe screening between five commercial biofilm carriers, based on a statistical analysis of the process rates and yields, led to the selection of Glaxstone®, a sintered glass porous material. The attached‐cell performances obtained when SA production was fed with cheese whey or with pure lactose were equivalent. The feasibility of a repeated batch process of SA production by biofilms of A. succinogenes was demonstrated in a Glaxstone®‐filled 1‐L packed bed bioreactor, and an effective sequence of biofilm growth and SA production phases was identified. A SA productivity of 0.72 gSA L−1packed bed h−1, a SA specific production rate of 0.18 gSA gprotein−1 h−1 and a biofilm concentration of about 4 g L−1packed bed were obtained.
CONCLUSIONSSA bioproduction under biofilm conditions from organic by‐products such as cheese whey is a feasible and promising process. This work represents the first attempt to develop a biofilm‐based process of SA bioproduction from cheese whey.
| Authors: | Luca Longanesi, Dario Frascari, Cecilia Spagni, Heleen DeWever, Davide Pinelli | |
| Journal: | Journal of Chemical Technology & Biotechnology | |
| Year: | 2017 | |
| Pages: | n/a | |
| DOI: | 10.1002/jctb.5347 | |
| Publication date: | 05-Jun-2017 |
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