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Abstract:
Background: The present study is an effort to extend the utility of the α,β-ditosyloxy chalcone derivatives in establishing the reaction patterns of these compounds which at once was thought that they might behave similar to α,β-dibromo ketones but the results
obtained were quite different and interesting in nature.
Methods: In the present methodology, the α,β-chalcone ditosylates containing pyrazoles were prepared from corresponding chalcone derivatives on treatment with [hydroxyl(tosyloxy)iodo]benzene in dichloromethane at room
temperature and that were further allowed to react with potassium hydroxide in methanol.
Results: A new series of acetylenic ketones were obtained in the present case in excellent yield. The analytical data of the compounds fully satisfy the structures of the compounds.
Conclusions:
In the present case, the α,β-chalcone ditosylates lead to the elimination of ditosyloxy groups and the products isolated are acetylenic ketones which are stable under the reaction conditions. Hence, it offers a facile and convenient route for the synthesis of acetylenic ketones
which are difficult to synthesize otherwise.
| Authors: | Ranjan, Pooja; Arora, Loveena; Prakash, Richa; K. Aneja, Deepak; Prakash, Om | |
| Journal: | Letters in Organic Chemistry | |
| DOI: | 10.2174/1570178614666170321121411 |
Abstract: Background: Azocalix[4] arene derivative based on 2,6-diamino pyridine has been synthesized from diazo-coupling reaction between tetradiazonium salt of calix[4]arene and 2,6-diaminopyridine, and characterized by various spectroscopic methods such as IR, 1HNMR, 13CNMR and Mass spe ... more
MSD-MAP: A Network-Based Systems Biology Platform for Predicting Disease-Metabolite Links
Abstract: Background: Cancer-associated metabolites result from cell-wide mechanisms of dysregulation. The field of metabolomics has sought to identify these aberrant metabolites as disease biomarkers, clues to understanding disease mechanisms, or even as therapeutic agents. Objective: Thi ... more
Antimalarials: Molecular Drug Targets and Mechanism of Action
Abstract: Background: Despite a reduction in the global burden of malaria, the disease remains responsible for 214 million cases and 438,000 deaths annually with 88% of the mortality occurring in sub-Saharan Africa. Malaria control largely depends on effective chemotherapy. However, the hi ... more
Synthesis of medicinally privileged heterocycles through dielectric heating
Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twent ... more
A new breakthrough in the synthesis of chiral 3,6-Dihydro-2H-pyrans
The pyran ring is present in so many useful compounds, such as pharmaceuticals (antibiotics, anti-infectives, cardiovascular agents, neurological modulators, anti-allergic, anti-asthmatic, anti-inflammatory agents, reproductive and genitourinary agents, growth promoters and antidiabetic age ... more
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