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A Highly Efficient Approach for the Synthesis of Novel Trifluoroacetylated Enaminones using DBU as a Base

DOI: 10.1055/s-0036-1588865

An efficient methodology has been developed for the synthesis of a variety of novel trifluoroacetylated enaminones by using trifluoroacetic anhydride in DCE as solvent and DBU as a base via electrophilic trifluoroacetylation. X-ray crystallographic studies confirmed the trifluoroacetylation and E stereoisomeric form of the novel compounds. The synthetic strategy has the advantage of using an inexpensive and non-toxic base for producing excellent yields. Synthons bearing variety of functional groups may be further extended for the formation of heterocyclic compounds.

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Authors:   P. Kumari; N. Sharma; A. Kumar; S. C. Mohapatra; S. Bhagat
Journal:   Synlett
Volume:   68
edition:   eFirst
Year:   2017
Pages:   10201
DOI:   10.1055/s-0036-1588865
Publication date:   21-Jun-2017
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