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Humic acid particle embedded super porous gum Arabic cryogel network for versatile use

Super porous gum Arabic (GA) cryogels were synthesized by crosslinking of natural GA with divinyl sulfone at cryogenic conditions, −20°C for potential biomedical applications. Humic acid (HA) nanoparticles were also prepared by using degradable and biocompatible crosslinkers such as trimethylolpropane triglycidyl ether, poly(ethylene glycol) diglycidyl ether, and trisodium trimetaphosphate in a single step and then entrapped within GA cryogel network as GA/HA particle cryogel. Furthermore, GA/HA cryogel was used as a template for Ag, Cu, and Fe nanoparticle preparation, and their antimicrobial properties were tested against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis strains. The minimum inhibition concentration values of Ag and Cu nanoparticle‐loaded GA/HA cryogel composites were determined as 10 mg mL−1. Furthermore, the blood compatibility tests such as hemolysis and blood clotting indexes were determined for GA cryogels and found to be more compatible with 0.08 ± 0.01% hemolysis and 89.4 ± 6.1 blood clotting values, whereas the hemolysis of the Ag, Cu, and Fe nanoparticle‐loaded GA/HA Ag, Cu, and Fe metal nanoparticle cryogel composites decreased in the order of Fe > Cu > Ag nanoparticles.

Authors:   Selin Sagbas Suner, Nurettin Sahiner
Journal:   Polymers for Advanced Technologies
Year:   2017
Pages:   n/a
DOI:   10.1002/pat.4097
Publication date:   06-Jul-2017
Facts, background information, dossiers
  • humic acid
  • hemolysis
  • Escherichia coli
  • Single
  • gum arabic
  • ethylene glycol
  • Cryogenic
  • crosslinking
  • crosslinkers
  • concentration
  • blood
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