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Single‐run capillary electrophoresis method for the fast simultaneous determination of amoxicillin, clavulanate, and potassium

We report a new fast method for the simultaneous determination of amoxicillin, clavulanate and potassium by capillary electrophoresis with capacitively coupled contactless conductivity detection. Samples containing potassium as the cation and both amoxicillin and clavulanate as anions were determined simultaneously in a single run (in less than 45 s) using 10 mmol L−1 of both 2‐amino‐2‐hydroxymethyl‐propane‐1,3‐diol and 3‐[{2‐hydroxy‐1,1‐bis(hydroxymethyl)ethyl}amino]‐1‐propanesulfonic acid (pH 8.4) as the background electrolyte. Limits of detection were 25.0, 5.0, and 4.0 μmol L−1 for amoxicillin, clavulanate and potassium, respectively. The proposed method is inexpensive, simple, fast (75 injections h−1), environmentally friendly (minimal waste generation) and accurate (recovery values between 98–103%). The results obtained with the proposed method were statistically similar (95% confidence level) to those obtained by using HPLC (amoxicillin and clavulanate) and flame photometry (potassium).

This article is protected by copyright. All rights reserved

Authors:   Mariana C. Marra, Rafael R. Cunha, Rodrigo A. A. Muñoz, Alex D. Batista, Eduardo M. Richter
Journal:   Journal of Separation Science
Year:   2017
Pages:   n/a
DOI:   10.1002/jssc.201700478
Publication date:   06-Jul-2017
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