Room Temperature Multicomponent Polymerizations of Alkynes, Sulfonyl Azides, and Iminophosphorane toward Heteroatom-Rich Multifunctional Poly(phosphorus amidine)s
Multicomponent polymerization (MCP) is a fascinating synthetic method for the construction of polymers with diverse structures and multifunctionalities. As a rapidly developing field, MCP begins to show great impact in polymer chemistry and polymer materials, which attract scientists’ attention by their high convenience and efficiency, great structure diversity, high atom economy, and environmental benefit. In this work, a facile one-pot three-component polymerization of diynes, disulfonyl azides, and iminophosphorane is developed to construct N, O, S, and P-containing heteroatom-rich poly(phosphorus amidine)s with advanced functionalities. The optimized MCP proceeds at room temperature in THF under the catalysis of CuI, generating polymers with high molecular weights (up to 85 600 g/mol) in excellent yields (up to 92%). The MCP enjoys general applicability of various monomers including aromatic and aliphatic alkynes, and the only byproduct generated from the polymerization is nitrogen gas, demonstrating ...
We recently generalized the formerly alignment-dependent multivariate image analysis applied to quantitative structure–activity relationships (MIA-QSAR) method through the application of the discrete Fourier transform (DFT), allowing for its application to noncongruent and structurally dive ... more
Poly-ADP-ribosylation (PARylation) is a protein posttranslational modification (PTM) that is critically involved in many biological processes that are linked to cell stress responses. It is catalyzed by a class of enzymes known as poly-ADP-ribose polymerases (PARPs). In particular, PARP1 is ... more
This review focuses on the type A cytochrome c oxidases (CcO), which are found in all mitochondria and also in several aerobic bacteria. CcO catalyzes the respiratory reduction of dioxygen (O2) to water by an intriguing mechanism, the details of which are fairly well understood today as a r ... more
Rohm and Haas Powder Coatings is delighted to announce that its Reading, Pennsylvania, facility is the first site in the world to receive the RCMS® Site Certification awarded by the American Chemical Council (ACC).
When Raj Gupta, Chairman and CEO of Rohm and Haas Company, became Chairman ... more