ConspectusThe precision design of topologically intriguing macromolecular architectures has continuously been an attractive challenge in polymer science and polymer materials engineering. A class of multicyclic polymer topologies, including three subclasses of spiro, bridged, and fused forms, are particularly unique not only from a topological geometry viewpoint but also from their biochemical relevance to programmed folding structures.In this Account, we describe recent progress in constructing this class of macromolecules, in particular by means of an electrostatic self-assembly and covalent fixation (ESA-CF) protocol, in which ion-paired polymer self-assemblies are employed as key intermediates. All three dicyclic constructions having either 8 (spiro), manacle (bridged), or θ (fused) forms, as well as a tricyclic trefoil (spiro) graph, have been constructed by the ESA-CF process. Moreover, a triply fused-tetracyclic macromolecular K3,3 graph has been constructed using a uniform-size dendritic polymer p...
We recently generalized the formerly alignment-dependent multivariate image analysis applied to quantitative structure–activity relationships (MIA-QSAR) method through the application of the discrete Fourier transform (DFT), allowing for its application to noncongruent and structurally dive ... more
Poly-ADP-ribosylation (PARylation) is a protein posttranslational modification (PTM) that is critically involved in many biological processes that are linked to cell stress responses. It is catalyzed by a class of enzymes known as poly-ADP-ribose polymerases (PARPs). In particular, PARP1 is ... more
This review focuses on the type A cytochrome c oxidases (CcO), which are found in all mitochondria and also in several aerobic bacteria. CcO catalyzes the respiratory reduction of dioxygen (O2) to water by an intriguing mechanism, the details of which are fairly well understood today as a r ... more
Rohm and Haas Powder Coatings is delighted to announce that its Reading, Pennsylvania, facility is the first site in the world to receive the RCMS® Site Certification awarded by the American Chemical Council (ACC).
When Raj Gupta, Chairman and CEO of Rohm and Haas Company, became Chairman ... more