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Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against sever

Authors:   Qingshuo Meng; Jia Meng; Wei Ran; Jinghan Su; Yuguang Yang; Pengcheng Zhang; Yaping Li
Journal:   Chemical Communication
DOI:   10.1039/C7CC07465D
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  • drugs
  • cancer drugs
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