My watch list  

One‐step Preparation of Monodisperse Multifunctional Macroporous Particles through a Spontaneous Physical Process


Macroporous particles that combine the property features of spherical structures and porous materials are expected to find use over micro‐ and macroscopic length scales from miniaturized systems such as cell imaging, drug and gene delivery to industrial applications. However, the capacity for de novo design of such materials is still limited. Here, a spontaneous process to fabricate monodisperse multifunctional macroporous particles (MMMPs) by high internal phase emulsion templating is reported. An interesting physical phenomenon involving self‐emulsification and synergistic effects between nanoparticles and amphiphilic diblock copolymers is observed in this process. These MMMPs, featured with tailor‐made pore structures, pH responsiveness, and magnetic response, could be used as stimuli‐responsive carriers for multiple functional molecules with a high loading and releasing efficiency. This new understanding regarding the underlying phenomena that control self‐emulsification behavior and synergistic action in emulsion systems provides a unique outlook and a novel approach to the design of potentially multifunctional porous materials for controllable release and delivery processes.

Monodisperse multifunction macroporous particles are prepared through one‐step self‐emulsification using spontaneously formed high internal phase emulsions as templates. Dual component emulsifiers of polystyrene‐b‐poly(4‐vinylpyridine) copolymers and Fe3O4 nanoparticles also serve as functional components with pH‐ and magnetic responsiveness. These macroporous particles hold great promise for practical applications in controllable release and delivery processes.

Authors:   Xueyan Feng, Xiuyu Wang, Di Zhang, Feng Feng, Li Yao, Guiping Ma
Journal:   Small
Year:   2017
Pages:   n/a
DOI:   10.1002/smll.201703570
Publication date:   22-Dec-2017
Facts, background information, dossiers
  • cell imaging
More about Wiley
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE