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Continuous Flow Synthesis of Urea‐Containing Compound Libraries Based on the Piperidin‐4‐one Scaffold

The advantages of performing reactions in continuous flow versus the classic batch processes render flow chemistry a suitable technique for library synthesis. Inspired by our recent work to create fluorine‐containing N‐heterocycles and by the potential of the urea group in drug design, we herewith describe the combination of both in the continuous flow synthesis of two libraries of urea derivatives based on the piperidin‐4‐one scaffold.

Authors:   Alejandra Riesco-Dominguez, Daniel Blanco-Ania, Floris P. J. T. Rutjes
Journal:   European Journal of Organic Chemistry
Year:   2017
Pages:   n/a
DOI:   10.1002/ejoc.201701539
Publication date:   20-Dec-2017
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