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Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals

The infrastructure for chemical synthesis typically lies at either end of a spectrum: small-scale studies in ad hoc assemblies of glassware or large-scale production in capital-intensive custom reactors. Kitson et al. report a hybrid protocol that customizes a blueprint for synthesis of a target compound in a series of interconnected plastic modules, which can be assembled en masse by 3D printing (see the Perspective by Hornung). The approach, demonstrated for the commercial muscle relaxant baclofen, establishes a systematic workflow that is potentially amenable to automation: All that is necessary for synthesis and purification is the introduction of stock solutions and variation of temperature or pressure. Science , this issue p. [314][1]; see also p. [273][2] [1]: /lookup/doi/10.1126/science.aao3466 [2]: /lookup/doi/10.1126/science.aar4543

Authors:   Philip J. Kitson; Guillaume Marie; Jean-Patrick Francoia; Sergey S. Zalesskiy; Ralph C. Sigerson; Jennifer S. Mathieson; Leroy Cronin
Journal:   Science
Volume:   359
edition:   6373
Year:   2018
Pages:   314
DOI:   10.1126/science.aao3466
Publication date:   19-Jan-2018
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