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Remote C‐H Activation of Various N‐Heterocycles Using a Single Template

A single simple ortho‐sulfonyl benzonitrile template was developed to achieve remote C‐H olefination of six different classes of N‐heterocycles. We demonstrate that, by varying precatalysts and conditions, the same template can be applied to the remote C‐H activation of six structurally distinct heterocyclic scaffolds, and the site‐selectivity can be predicted based on distance and geometry. Furthermore, this new development shows that template‐directed remote C‐H activation are possible via macrocyclopalladation processes with smaller ring sizes.

Authors:   Guoqiang Yang, Dajian Zhu, Peng Wang, Ri-Yuan Tang, Jin-Quan Yu
Journal:   Chemistry - A European Journal
Year:   2018
Pages:   n/a
DOI:   10.1002/chem.201800105
Publication date:   18-Jan-2018
Facts, background information, dossiers
  • Single
  • scaffolds
  • Olefination
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