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Mannose-Modificated Polyethylenimine: A Specific and Effective Antibacterial Agent against Escherichia coli

Polyethylenimine (PEI) has antimicrobial activity against Gram-positive (Staphylococcus aureus, S. aureus) and Gram-negative (Escherichia coli, E. coli), bacteria but is highly cytotoxic, and the selective antimicrobial activity against S. aureus is obviously better than that against E. coli. To reduce the cytotoxicity and improve the antibacterial activity against E. coli, we modified PEI with d-mannose through nucleophilic addition between primary amine and aldehyde groups to get mannose-modified polyethylenimine copolymer particles (Man-PEI CPs). The use of mannose may provide good targeting ability toward E. coli pili. The antibacterial activity of Man-PEI CPs was investigated. Man-PEI CPs shows specific and very strong killing capability against E. coli at a concentration of 10 μg/mL, which is the highest antimicrobial efficiency compared to that of unmodified PEI (220 μg/mL). The antibacterial mechanism demonstrated that the enhancement in antibacterial activity is due to specific recognition of the...

Authors:   Mei Liu; Jiao Li; Baoxin Li
Journal:   Langmuir
Year:   2018
DOI:   10.1021/acs.langmuir.7b03556
Publication date:   18-Jan-2018
Facts, background information, dossiers
  • Escherichia coli
  • Staphylococcus aureus
  • polyethylenimine
  • pili
  • Nucleophilic addition
  • cytotoxicity
  • concentration
  • bacteria
  • Aldehyde
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