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Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging

Biomimetic fluorescent nanoprobes capable of emitting near-infrared (NIR) fluorescence (λmax ≈ 720 nm) upon excitation of 800 nm light were developed. The key conjugated polymer enabled two-photon absorption and Förster resonance energy transfer (FRET) processes within the nanoprobes, which imparted the nanoprobes with ideal NIR-incoming-NIR-outgoing fluorescence features. The cancer cell membrane (CM) coating endowed these nanoprobes with perfect biocompatibility and highly specific targeting ability to homologous tumors. It was believed that CM encapsulation provided an additional protecting layer for the photoactive components residing in the core of nanoprobes for retaining their intrinsic fluorescing ability in the physiological milieu. The long-term structural integrity, excellent photostability (fluorescence decrease <10% upon 30 min illumination of 800 nm pulse laser), high NIR fluorescence quantum yield (∼20%), and long in vivo circulation time of the target nanoprobes were also confirmed. The ab...

Authors:   Yanlin Lv; Ming Liu; Yong Zhang; Xuefei Wang; Fan Zhang; Feng Li; Wei-Er Bao; Jie Wang; Yuanlin Zhang; Wei Wei; Guanghui Ma; Liancheng Zhao; Zhiyuan Tian
Journal:   ACS Nano
Year:   2018
DOI:   10.1021/acsnano.7b07716
Publication date:   19-Jan-2018
Facts, background information, dossiers
  • tumors
  • light
  • fluorescence imaging
  • absorption
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