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Brønsted Acid‐Catalyzed Tandem Cyclizations of Tryptamine‐Ynamides Yielding 1H‐Pyrrolo[2,3‐d]carbazole Derivatives

A highly efficient novel method for the construction of the core tetracyclic motif of numerous biologically active indole alkaloids was described. The cyclization precursors were easily prepared from tryptamine derivatives in five steps with excellent yields. The full potential of the developed method was demonstrated by the synthesis of Büchi ketone, a well‐known intermediate in the synthesis of vindorosine. More information can be found in the Full Paper by Y. Liu, M. Cheng et al. (DOI: 10.1002/chem.201705189).

Authors:   Yanshi Wang, Jingsheng Lin, Xiaoyu Wang, Guanghui Wang, Xinhang Zhang, Bo Yao, Yuandong Zhao, Pengfei Yu, Bin Lin, Yongxiang Liu, Maosheng Cheng
Journal:   Chemistry - A European Journal
Year:   2018
Pages:   n/a
DOI:   10.1002/chem.201706014
Publication date:   17-Jan-2018
Facts, background information, dossiers
  • indole
  • Cyclization
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