My watch list
my.chemeurope.com  
Login  

Localized Three-Dimensional Functionalization of Bionanoreceptors on High-Density Micropillar Arrays via Electrowetting

In this work, we introduce an electrowetting-assisted 3-D biofabrication process allowing both complete and localized functionalization of bionanoreceptors onto densely arranged 3-D microstructures. The integration of biomaterials with 3-D microdevice components offers exciting opportunities for communities developing miniature bioelectronics with enhanced performance and advanced modes of operation. However, most biological materials are stable only in properly conditioned aqueous solutions, thus the water-repellent properties exhibited by densely arranged micro/nanostructures (widely known as the Cassie–Baxter state) represent a significant challenge to biomaterial integration. Here, we first investigate such potential limitations using cysteine-modified tobacco mosaic virus (TMV1cys) as a model bionanoreceptor and a set of Au-coated Si-micropillar arrays (μPAs) of varying densities. Furthermore, we introduce a novel biofabrication system adopting electrowetting principles for the controlled localizatio...

Authors:   Sangwook Chu; Thomas E. Winkler; Adam D. Brown; James N. Culver; Reza Ghodssi
Journal:   Langmuir
Year:   2018
DOI:   10.1021/acs.langmuir.7b02920
Publication date:   18-Jan-2018
Facts, background information, dossiers
  • biofabrication
  • water
  • tobacco mosaic virus
  • biomaterials
  • bioelectronics
More about American Chemical Society Publications
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE